Assessment and comparison of phagocytic function and viability of polymorphonuclear leukocytes in saliva of smokers and non-smokers

Archana, .; Bagewadi, Anjana; Keluskar, Vaishali

doi:10.1016/j.archoralbio.2014.09.018

Cited by 11 publications

(8 citation statements)

References 13 publications

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“…The chemotactic mobility and phagocytic function of oral polymorphonuclear leukocytes is diminished in smokers (Noble and Penny, 1975;Kenney et al, 1977;Archana et al, 2015); as these cells are crucial to the host defense against pathogens, smoking inherently promotes a more pathogen-friendly oral ecosystem, thus increasing risk for oral disease (e.g. periodontitis).…”

Section: Discussionmentioning

confidence: 99%

Cigarette smoking and the oral microbiome in a large study of American adults

et al. 2016

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Oral microbiome dysbiosis is associated with oral disease and potentially with systemic diseases; however, the determinants of these microbial imbalances are largely unknown. In a study of 1204 US adults, we assessed the relationship of cigarette smoking with the oral microbiome. 16S rRNA gene sequencing was performed on DNA from oral wash samples, sequences were clustered into operational taxonomic units (OTUs) using QIIME and metagenomic content was inferred using PICRUSt. Overall oral microbiome composition differed between current and non-current (former and never) smokers (Po0.001). Current smokers had lower relative abundance of the phylum Proteobacteria (4.6%) compared with never smokers (11.7%) (false discovery rate q = 5.2 × 10 −7 ), with no difference between former and never smokers; the depletion of Proteobacteria in current smokers was also observed at class, genus and OTU levels. Taxa not belonging to Proteobacteria were also associated with smoking: the genera Capnocytophaga, Peptostreptococcus and Leptotrichia were depleted, while Atopobium and Streptococcus were enriched, in current compared with never smokers. Functional analysis from inferred metagenomes showed that bacterial genera depleted by smoking were related to carbohydrate and energy metabolism, and to xenobiotic metabolism. Our findings demonstrate that smoking alters the oral microbiome, potentially leading to shifts in functional pathways with implications for smoking-related diseases.

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Section: Discussionmentioning

confidence: 99%

Cigarette smoking and the oral microbiome in a large study of American adults

et al. 2016

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“…Although smoking has effects on multiple biological systems that may predispose to chronic periodontitis-including amplification of cholinergic anti-inflammatory signaling, [24][25][26] a reduced antibody response, [27][28][29][30][31] suppressed immune cell function, [32][33][34][35] promotion of osteoclast/osteoblast imbalance, 36,37 a depleted antioxidant defense, 38,39 and compromised tissue remodeling [40][41][42] -this review will focus specifically on the vascular response itself.…”

Section: N V I T E D R E V I E W a R T I C L Ementioning

confidence: 99%

Tobacco‐induced suppression of the vascular response to dental plaque

Buduneli

Scott

2018

Molecular Oral Microbiology

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Cigarette smoking presents oral health professionals with a clinical and research conundrum: reduced periodontal vascular responsiveness to the oral biofilm accompanied by increased susceptibility to destructive periodontal diseases. This presents a significant problem, hampering diagnosis and complicating treatment planning. The aim of this review is to summarize contemporary hypotheses that help to explain mechanistically the phenomenon of a suppressed bleeding response to dysbiotic plaque in the periodontia of smokers. The influence of smoke exposure on angiogenesis, innate cell function, the production of inflammatory mediators including cytokines and proteases, tobacco-bacteria interactions, and potential genetic predisposition are discussed.

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“…Nicotine is a major harmful substance found in tobacco, and nicotine derivatives are vasoconstrictive on peripheral, coronary, placental and gingival blood vessels. Tobacco use may reduce the functional activities of polymorphonuclear leucocytes including chemotaxis and phagocytosis (Archana, Bagewadi, & Keluskar, ). In addition, smoking has a significant systemic effect on immunoglobulin (IgG) levels (Engdahl et al, ).…”

Section: Discussionmentioning

confidence: 99%

Interaction between beta‐3 adrenergic receptor genotype and environmental factors on periodontal progression

Yoshihara

Kaneko

Nohno

et al. 2019

J Clinic Periodontology

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Objectives The purpose of this longitudinal study was to evaluate the relationship between beta‐3 adrenergic receptor polymorphism and environmental factors such as smoking on periodontal disease by considering effect modification. Materials and Methods A total of 294 subjects who participated in all follow‐up surveys over the 6‐year study period were analysed. After dividing subjects into tertiles according to the number of years exposed to smoking, we conducted Poisson regression analysis to compare the incidence rate ratio (IRR) for periodontal disease events during the 6‐year study period with beta‐3 adrenergic receptor genotype (1: Arg allele carriers, 2: Arg allele non‐carriers) for each tertile adjusted for other four variables. Results The number of years exposed to smoking (mean ± standard deviation) for the 1st, 2nd and 3rd tertiles was 0 ± 0, 20.1 ± 9.1 and 45.3 ± 7.7 years, respectively. The IRRs ± SE were 0.89 ± 0.08 (p = 0.218) for the 1st tertile, 1.93 ± 0.36 (p < 0.001) for the 2nd tertile and 2.56 ± 0.23 (p < 0.001) for the 3rd tertile. Conclusion There was a clear dose–response relationship between beta‐3 adrenergic receptor genotype and periodontal disease progression based on the number of years exposed to smoking.

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Assessment and comparison of phagocytic function and viability of polymorphonuclear leukocytes in saliva of smokers and non-smokers

Cited by 11 publications

References 13 publications

Cigarette smoking and the oral microbiome in a large study of American adults

Cigarette smoking and the oral microbiome in a large study of American adults

Tobacco‐induced suppression of the vascular response to dental plaque

Interaction between beta‐3 adrenergic receptor genotype and environmental factors on periodontal progression

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