Assessment and identification of bioactive metabolites from terrestrial Lyngbya spp. responsible for antioxidant, antifungal, and anticancer activities

Verma, Shaloo; Suman, Prabhat; Mandal, Somnath; Kumar, Roshan; Sahana, Nandita; Siddiqui, Nahid; Chakdar, Hillol

doi:10.1007/s42770-023-01111-1

Cited by 4 publications

(1 citation statement)

References 75 publications

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“…Microglia are a common feature of many inflammatory and degenerative diseases of the retina, and they can quickly multiply in pathological conditions like inflammation and neuroinflammation. As a result, they play a role in the development and progression of a number of neurological disorders [60].…”

Section: Cns and Eye Neurodegenerationmentioning

confidence: 99%

Diabetic Retinopathy: Current Understanding, Mechanisms and Treatment Strategies

Amjad,

Gupta,

Anamika

et al. 2024

J. Res. Appl. Sci. Biotechnol.

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Researchers have been assuming about the possible connection between the eye and the central nervous system (CNS) for a considerable amount of time. This is primarily due to the fact that the eye is considered to be an extension of the brain, which is a reasonable assumption. The neural tube is the beginning of both structures, and neurons are the building blocks of both structures. Retinal ganglionic cells, also known as RGCs, are a specific type of cell that are found in the retina. These cells are responsible for receiving light signals from the environment around them and then transmitting them to photoreceptors, which are involved in the process of vision. The retina, which is found inside the eye, is responsible for converting light into electrical impulses, which are then sent to the brain through the optic nerve. Glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy are only few of the eye illnesses that can be caused by chronic progressive neurodegeneration of the retina, which is more prevalent in older people. It is the elderly who are most likely to be affected by these eye disorders; nevertheless, younger people are also susceptible to them and may experience permanent vision loss or a reduction in their eyesight. In most cases, neurodegenerative disorders that are characteristic of CSN are characterised by common symptoms and a cause that is only partially understood. Although certain risk factors have been identified, they do not account for all instances. On the other hand, according to a number of studies, several illnesses of the central nervous system (CNS), such as Alzheimer's disease (AD) and Parkinson's disease (PD), which are responsible for a significant amount of mortality and morbidity on a global scale, display distinctive alterations at the ocular level. It is helpful to be aware of potential linkages in order to have a better understanding of the mechanics on which onset occurs. In addition, experts have not yet reached a consensus regarding the factors that are responsible for these various disorders. In this overview, the symptoms of ocular illnesses are discussed in detail, with a particular focus on the interaction between the brain and the eye. At some point in the future, a more in-depth understanding could be of assistance in the development of innovative treatments that could help reduce or prevent blindness and improve quality of life.

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Section: Cns and Eye Neurodegenerationmentioning

confidence: 99%

Diabetic Retinopathy: Current Understanding, Mechanisms and Treatment Strategies

Amjad,

Gupta,

Anamika

et al. 2024

J. Res. Appl. Sci. Biotechnol.

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Algae as Crop Plants Being a Source of Bioactive Ingredients of Pharmaceutical and Dietary Importance

Jabłońska-Trypuć

2024

Agronomy

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Algae are currently used in many areas, including dietetics, pharmacy, cosmetology and to increase the nutritional value of food and animal feed due to their chemical composition. They are a source of extremely valuable molecules, including polyunsaturated fatty acids and pigments. Algae are also a valuable source of protein and almost all essential vitamins. They are rich in pigments such as chlorophyll, carotenoids and phycobiliproteins. These substances have a wide range of commercial applications. Due to its very intensive use, the demand for this plant raw material is constantly growing. Therefore, the methods of growing and harvesting algae are constantly improved in order to maximize the cultivation effect while minimizing costs and energy inputs. Future research should focus on improving algae cultivation and harvesting systems, with an emphasis on the possibility of genetic modifications that would allow even more efficient algae cultivation. This review summarizes methods of micro- and macroalgae cultivation, the chemical composition of selected algae species, which are important from the pharmaceutical, dietary and cosmetic points of view and therapeutic and dietary applications of compounds derived from different algae species. The key conclusion drawn from this article is that algae are an extremely valuable raw material, rich in numerous macro- and micronutrients necessary for humans, the acquisition of which is part of the currently important strategy of ecological policy for obtaining raw materials for various industries.

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Formulation & Evaluation of Anti Migrane Mouth Dissolving Tablet

Upadhyay,

Sonaji,

Naaz

2024

J. Res. Appl. Sci. Biotechnol.

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The objective of this study is to improve the safety, efficacy, and rate of action of the existing molecule by utilising novel techniques to the administration of medication. This will be accomplished by the application of novel approaches. Orally disintegrating pills containing rizatriptan benzoate were made by the direct compression technique in order to provide migraine sufferers with a more expedient manner of gaining relief from their condition. For the purpose of this inquiry, a 32-factororial design method was utilised, and eight different formulations were examined for each of the super disintegrants that were explored. There were a number of tests that were performed on the batches of tablets that were manufactured. These tests included weight variation, hardness, friability, wetting time, invitro dispersion time, drug content, and invitro dissolution. A UV spectrophotometric approach that is easy, sensitive, rapid, accurate, cost-effective, and repeatable was created in order to identify the dose form of Rizatriptan Benzoate tablets. This method was designed in order to determine the dose form. It has been determined that rizatriptan benzoate has the maximum absorbance at a wavelength of 225 nm, and its molar absorption is measured to be 1.619 Ao. According to Beer's law, the application of the law was observed between 1 and 10 μg/ml. In order to validate the conclusions of the investigation, statistical analysis and recovery studies were carried out. In order to validate the method, a number of various criteria were utilised. These criteria included linearity, accuracy, limit of detection (LOD), limit of quantification (LOQ), Sandell's sensitivity, and specificity were among the criteria that were utilised. The practice of determining the regular dosage of Rizatriptan Benzoate in both tablet and bulk forms was found to be one that is accurate and precise via the utilisation of the preferred method. This was identified through the utilisation of the recommended method. A time period ranging from fifteen to thirty seconds was required for the optimised formulation to be distributed throughout the body. Furthermore, it demonstrated a greater water absorption ratio and released 99.60% of the medication over a period of two minutes and fifteen seconds. This was in addition to everything else that it shown.

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Assessment and identification of bioactive metabolites from terrestrial Lyngbya spp. responsible for antioxidant, antifungal, and anticancer activities

Cited by 4 publications

References 75 publications

Diabetic Retinopathy: Current Understanding, Mechanisms and Treatment Strategies

Diabetic Retinopathy: Current Understanding, Mechanisms and Treatment Strategies

Algae as Crop Plants Being a Source of Bioactive Ingredients of Pharmaceutical and Dietary Importance

Formulation & Evaluation of Anti Migrane Mouth Dissolving Tablet

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