Assessment and management of the SARS-CoV-2 infection: A secondary center experience

Abstract

Background: The aim of the study was to evaluate the management and outcomes of the patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a secondary hospital. Methods: A total of 699 hospitalized patients who had positive rRT-PCR for SARS-CoV-2 and/or typical findings of COVID-19 at chest computed tomography (CT) were enrolled in this study. Demographics, comorbities, initial laboratory tests on admission, treatment modalities, complications and outcomes were evaluated retrospectively. Results: The mean age was 57.0±15.6 (range:16-94 years), and male:female ratio was 1.24. 58.7% of the patients had at least one underlying comorbidity, the most common was hypertension. 72.8% of the patients had positive RT-PCR. 18.1% of the patients had lymphopenia, 35.7% hyperferritinemia, 58.3% increased lactate dehydrogenase, and 58.5% increased D-dimer. Chest CT revealed moderate and severe stage in 57.9% of the patients, and bilateral lung involvement in 78.7%. Hydroxychloroquine was given to 37.2% and favipiravir 67.1% of the patients. No significant difference was observed between treatment groups in terms of mortality (P=0.487). 5.8% of the patients were transferred to the ICU, of whom 75.6% were needed non-invasive and 36.5% invasive mechanical ventilation. The overall case fatality rate was 0.9. Conclusions: Older age, male sex, low lymphocyte count, CT findings including bilateral involvement and severe stage were significantly associated with poor prognosis and mortality.

Analysis of risk factors for deep vein thrombosis after spinal infection surgery and construction of a nomogram preoperative prediction model

“…For example, in cases of acute appendicitis, MPV levels were significantly lower than in controls (Fan et al, 2017). Plateletcrit, which is the percentage of platelet volume in peripheral blood to whole blood volume, is the product of PLT and MPV, and decreased levels of Plateletcrit have been suggested to be associated with sepsis and poor prognosis in systemic inflammatory diseases in established studies (Sayed et al, 2020;Yardımcı et al, 2021). Shortening of APTT as an indicator of coagulation is usually indicative of a hypercoagulable state, and APTT light transmission waveform analysis is currently used by some investigators as a tool to detect infection and assess its prognosis (Chopin et al, 2006).…”