This study extensively explores the impact of climate change on meteorological droughts within metropolises in Iran. Focused on Tehran, Mashhad, Isfahan, Karaj, Shiraz, and Tabriz, this research employed CMIP6 climate models under varying climate change scenarios (SSPs) to forecast severe meteorological droughts spanning the period from 2025 to 2100. The investigation utilized a diverse set of drought indices (SPI, DI, PN, CZI, MCZI, RAI, and ZSI) to assess the drought severity in each city. This study is crucial as it addresses the pressing concerns of rapidly decreasing water levels in Iran’s dams, serious declines in underground aquifers, and the compounding issues of land subsidence and soil erosion due to excessive groundwater withdrawal in the face of severe droughts. This study culminated in the generation of box plots and heatmaps based on the results. These visual representations elucidated the distribution of the drought values under different indices and scenarios and provided a depiction of the probability of severe drought occurrences until the end of the century for each city. The resulting findings serve as invaluable tools, furnishing policymakers with informed insights to proactively manage and fortify metropolitan resilience against the evolving challenges posed by a changing climate.