Assessment and prediction of malnutrition and sarcopenia in liver cirrhosis patients

Sehgal, Pallavi; Sharma, Sonika; Sood, Ajit; Dharni, Khushdeep; Kakkar, Chandan; Batta, Shaveta; Sahotra, Mathew

doi:10.1186/s41110-023-00189-9

Cited by 2 publications

(3 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relation between nutritional status, muscle functionality (measured by handgrip strength), and muscle mass (determined by the skeletal muscle index (SMI)) is connected to the development of sarcopenia as demonstrated by Sehgal P. et al [41].…”

Section: Correlation Of Muscle Health and Bcaas In Patients With Cldmentioning

confidence: 96%

Clinical and Therapeutic Implications of BCAAs Metabolism during Chronic Liver Disease in Humans: Crosstalk between Skeletal Muscle and Liver

Trillos-Almanza,

Martinez-Aguilar,

Arroyave-Ospina

et al. 2024

Muscles

View full text Add to dashboard Cite

This comprehensive review focuses on the dynamics of branched-chain amino acids (BCAAs) metabolism and its clinical implications in chronic liver disease, with emphasis on the emerging concept of muscle–liver crosstalk. BCAAs, indispensable for protein synthesis and metabolic pathways, undergo unique tissue-specific processing in skeletal muscle and liver. The liver, responsible for amino acid metabolism, plays a distinctive role in sensing BCAAs catabolism, influencing glucose regulation and contributing to the systemic metabolism of BCAAs. Within the context of chronic liver disease, compromised liver metabolism becomes evident through amino acid abnormalities, particularly in the decrease of the Fischer ratio (BCAAs/aromatic amino acids concentrations in plasma). This reduction becomes important in assessing the severity of liver dysfunction due to its associations with adverse outcomes, including increased mortality and complications related to the liver disease. BCAAs supplementation, as explored in this review, emerges as a promising avenue, displaying positive effects on skeletal muscle mass, strength, and overall nutritional status in cirrhosis management. Understanding this interplay offers insights into therapeutic strategies for chronic liver diseases, exploring the way for precision interventions in clinical practice.

show abstract

Section: Correlation Of Muscle Health and Bcaas In Patients With Cldmentioning

confidence: 96%

Clinical and Therapeutic Implications of BCAAs Metabolism during Chronic Liver Disease in Humans: Crosstalk between Skeletal Muscle and Liver

Trillos-Almanza,

Martinez-Aguilar,

Arroyave-Ospina

et al. 2024

Muscles

View full text Add to dashboard Cite

show abstract

“…The GLIM consensus recommends that nutritional status be assessed on the basis of phenotypic criteria (low body mass index, unintentional weight loss, and loss of muscle mass) in combination with etiologic criteria (reduced intake or assimilation, and disease or inflammatory conditions); at least one of the phenotypic and one of the etiologic criteria must be present in order to make a diagnosis of malnutrition. A meta-analysis showed that the GLIM criteria have high diagnostic accuracy in differentiating malnutrition and have the potential to become the gold standard for diagnosing malnutrition in clinical practice ( 72 ). Malnutrition as defined by GLIM was associated with significantly higher in-hospital mortality and poor clinical outcomes ( 72 , 73 ).…”

Section: Assessment Of Malnutritionmentioning

confidence: 99%

“…A meta-analysis showed that the GLIM criteria have high diagnostic accuracy in differentiating malnutrition and have the potential to become the gold standard for diagnosing malnutrition in clinical practice ( 72 ). Malnutrition as defined by GLIM was associated with significantly higher in-hospital mortality and poor clinical outcomes ( 72 , 73 ). It is worth noting that there is no uniformity in the GLIM diagnostic criteria for loss of muscle mass.…”

Section: Assessment Of Malnutritionmentioning

confidence: 99%

Screening and assessment of malnutrition in patients with liver cirrhosis

He,

Wang,

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

The development and advancement of malnutrition is associated not only with the progression of hepatic dysfunction, but also with cirrhosis-related complications. However, the prevalence of malnutrition reported in different studies varies widely due to differences in diagnostic methods and patient investigation settings. Therefore, we need to identify malnourished patients promptly and accurately. The purpose of this review was to compare the validity and reliability of nutritional screening tools and to select the most appropriate nutritional risk screening for patients with cirrhosis. We compared nutritional risk screening tools such as the Nutritional Risk Screening 2002 (NRS-2002), Malnutrition Universal Screening Tool (MUST), Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) and Liver Disease Undernutrition Screening Tool (LDUST). Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) is more feasible to screen cirrhotic patients for nutritional risk, and is highly reproducible, considering the impact of sodium and water retention; so it is practical to screen cirrhotic patients via RFH-NPT for nutritional risk, subsequently, to evaluate the nutritional status of patients with nutritional risk via the Global Leadership Initiative on Malnutrition (GLIM) diagnostic criteria. L3-SMI (third lumbar-skeletal muscle index) can accurately define sarcopenia in cirrhotic patients and also be used for clinical nutritional status assessment.

show abstract

Assessment and prediction of malnutrition and sarcopenia in liver cirrhosis patients

Cited by 2 publications

References 46 publications

Clinical and Therapeutic Implications of BCAAs Metabolism during Chronic Liver Disease in Humans: Crosstalk between Skeletal Muscle and Liver

Clinical and Therapeutic Implications of BCAAs Metabolism during Chronic Liver Disease in Humans: Crosstalk between Skeletal Muscle and Liver

Screening and assessment of malnutrition in patients with liver cirrhosis

Contact Info

Product

Resources

About