Introduction: Successful approaches to managing physical and psychosocial impacts on quality of life (QoL) of people with ankylosing spondylitis (AS) are grounded in their sociocultural and religious perspectives. The purpose of this study was to assess the QoL of Muslim patients with AS in Türkiye. Methodology: This descriptive, cross-sectional study was conducted in 101 patients. The data were collected using a Demographic Form and the Ankylosing Spondylitis Quality of Life Index. Results: It was determined that the QoL of those who use medication regularly and whose physical activity, psychological state, social and sexual life are affected is statistically significantly worse ( p < .05). Discussion: Results can provide better understanding of the QoL of Muslim patients and physical, social, and psychological influences of AS on QoL in this population. These results may have substantial impact on designing interventions to improve the QoL of Muslim patients with AS and the factors affecting it.