Assessment of 17 Pediatric Cases With Colchicine Poisoning in a 2-Year Period

Alaygut, Demet; Kılıç, Suar Çakı; Kaya, Ali; Oflaz, Mehmet Burhan; Bolat, Fatih; Cevit, Ömer; İçağasıoğlu, Füsun Dilara

doi:10.1097/pec.0000000000000728

Cited by 13 publications

(11 citation statements)

References 22 publications

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“…However, hair loss may not always be present. In a case series by Alaygut et al [41], only 1 out of 17 children with colchicine toxicity developed alopecia. The patient was a 16-year-old female who ingested colchicine prescribed for her father’s Behçet’s disease.…”

Section: Resultsmentioning

confidence: 99%

“…The patient was a 16-year-old female who ingested colchicine prescribed for her father’s Behçet’s disease. Although Bismuth et al [35, 36] reported 100% mortality at 0.8 mg/kg, this patient ingested 0.88 mg/kg of colchicine in a suicide attempt and miraculously survived [41]. In a separately reported suicide attempt, a 17-year-old female ingested 40 mg of colchicine with sudden anagen effluvium of the scalp on the seventh day after ingestion [42].…”

Section: Resultsmentioning

confidence: 99%

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Alopecia and Associated Toxic Agents: A Systematic Review

Juhász

Chiang

et al. 2018

Skin Appendage Disord

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Importance/Objective: There are a number of toxic agents that can cause alopecia. In this review we summarize the known substances that cause alopecia as one of the clinical signs of overdose or toxicity. Evidence Review: A search was conducted using PubMed, EMBASE, and Cochrane for studies describing hair loss of any type as a result of exposure to or ingestion of a toxic agent. The search yielded 856 articles, with 47 studies included in this review. Findings: Agents with the strongest evidence of association to alopecia include thallium, mercury, selenium, and colchicine. Agents with described incidents include boric acid, arsenic, vitamin A, botulinum toxin, Podostroma cornu-damae, and the synthetic opioid MT-45. Conclusions and Relevance: Numerous toxic agents have been implicated in alopecia, and the strength of evidence behind each agent varies. Toxic levels of thallium and colchicine have long been established to cause alopecia, as compared to agents such as botulinum toxin A and synthetic recreational drugs which have less literature describing their links to alopecia and will need further investigation to characterize their relationships to hair loss. Knowledge of typical presentations of hair loss will aid in the development of a differential diagnosis for patients presenting with alopecia.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Alopecia and Associated Toxic Agents: A Systematic Review

Juhász

Chiang

et al. 2018

Skin Appendage Disord

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“…Given the mechanism of action, it may be similar to drugs that disrupt microtubule polymerization, such as colchicine. It has been reported that cytopenia and AE are seen in acute intoxication of colchicine (12,15). With side effects such as alopecia, cytopenia may also be associated with pharmacokinetic variations of albendazole.…”

Section: Discussionmentioning

confidence: 99%

Albendazole-induced anagen effluvium: a brief literature review and our own experience

Turan

Metin

2020

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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Albendazole is a drug commonly used for treating many parasitoses. The primary mechanism of action is inhibition of microtubule polymerization binding to β-tubulin, similar to colchicine as a microtubule formation inhibitor. It is reasonable that these two antimitotic drugs can cause side effects such as alopecia and cytopenia by a similar mechanism. In the literature, only one albendazole-induced anagen effluvium has been reported. This article presents two cases of anagen effluvium that developed 2 weeks after oral albendazole administration, summarizes all cases reported to date, and offers recommendations for a diagnostic approach.

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“…It’s plasma peak concentrations are detected at 0.5 to 3 h after ingestion [ 10 ]. After assessment of 17 pediatric cases with colchicine poisoning, Alaygut et al [ 11 ] concluded that patients arrived at the hospital on average 7.3 h after taking colchicine. We reviewed the medical history of this case and found that the patient was sent to hospital 6 h after ingesting colchicine.…”

Section: Discussionmentioning

confidence: 99%

A rare case report of heavy dose colchicine induced acute kidney injury

Zhong

et al. 2018

BMC Pharmacol Toxicol

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BackgroundColchicine is a natural alkaloid that is mainly used for the treatment of inflammatory diseases. Effective and toxic doses are very similar, but case reports of higher colchicine doses inducing acute toxicosis is rare.Case presentationA 19-year-old woman was sent to the emergency room for taking 80 colchicine tablets (0.5 mg per tablet) 44 h previously. The main physical symptom was abdominal pain. Following ingestion, the patient suffered multi-system failure including renal, respiratory, circulatory, and digestive. Continuous renal replacement therapy (CRRT) and other treatment measures were used to remove metabolic wastes and poisons, and to treat other complications. Renal function was restored after a series of treatments.ConclusionWe report a case of an acute kidney injury induced by an overdose of colchicine. CRRT and a series of related treatments were beneficial for the treatment of colchicine poisoning.Electronic supplementary materialThe online version of this article (10.1186/s40360-018-0260-z) contains supplementary material, which is available to authorized users.

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Assessment of 17 Pediatric Cases With Colchicine Poisoning in a 2-Year Period

Cited by 13 publications

References 22 publications

Alopecia and Associated Toxic Agents: A Systematic Review

Alopecia and Associated Toxic Agents: A Systematic Review

Albendazole-induced anagen effluvium: a brief literature review and our own experience

A rare case report of heavy dose colchicine induced acute kidney injury

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