Assessment of a decision making protocol to improve the efficacy of VELscope™ in general dental practice: A prospective evaluation

Bhatia, Nirav; Matias, Marie Anne Teresa J.; Farah, Camile S.

doi:10.1016/j.oraloncology.2014.07.002

Cited by 50 publications

(88 citation statements)

References 33 publications

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“…On the other hand, alterations in the stromal architecture of dysplastic tissue are associated with a loss of autofluorescence (LAF). 23 A recent report suggests that vital bone is autofluorescent, whereas necrotic bone lost AF, induced by a fluorescence lamp. 24 The aim of this article is to describe an AF-guided surgical approach based on the use of Er:YAG laser and Nd:YAG LLLT.…”

Section: Introductionmentioning

confidence: 99%

Medication-Related Osteonecrosis of the Jaw: An Autofluorescence-Guided Surgical Approach Performed with Er:YAG Laser

Vescovi

Giovannacci

Otto

et al. 2015

Photomedicine and Laser Surgery

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Section: Introductionmentioning

confidence: 99%

Medication-Related Osteonecrosis of the Jaw: An Autofluorescence-Guided Surgical Approach Performed with Er:YAG Laser

Vescovi

Giovannacci

Otto

et al. 2015

Photomedicine and Laser Surgery

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“…This phenomenon is referred to as loss of AF (LAF). Light pressure should be applied to lesions which appear to lose AF to ascertain whether the lesions display diascopic fluorescence (DF), characterised by the return of AF on blanching, representing vascular or inflammatory pathology . DF diminishes the rate of false‐positive findings associated with inflammatory conditions, which also undergo loss of AF due to higher content of light‐absorbing haemoglobin …”

Section: Introductionmentioning

confidence: 99%

“…The use of OFI to identify OED and malignancy, as well as differentiating these conditions from benign pathologies has been the focus of numerous studies . While there is great variation in sensitivity and specificity reported, the consensus is that the VELscope ® has a moderate to high sensitivity but low specificity .…”

Section: Introductionmentioning

confidence: 99%

“…However, a number of studies fail to assess DF associated with inflammatory lesions, resulting in high false‐positive rates. It is therefore important to correlate OFI findings with clinical findings, which can significantly reduce the number of false‐positive results . Further reduction in false‐positive findings is also achieved by reviewing lesions several weeks after initial presentation to allow time for inflammatory lesions to resolve as detailed by us and others …”

Section: Introductionmentioning

confidence: 99%

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Usefulness of optical fluorescence imaging in identification and triaging of oral potentially malignant disorders: A study of VELscope in the LESIONS programme

Farah

Dost²,

2019

J Oral Pathology Medicine

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Background Optical fluorescence imaging (OFI) has been shown to enhance the detection of oral potentially malignant disorders (OPMD), by providing additional information about the nature of these lesions, with loss of autofluorescence (LAF) signifying potential underlying oral epithelial dysplasia (OED) or malignancy. This study aims to assess the usefulness of OFI in identification and triaging of OPMDs by primary oral health practitioners, in a community setting. Methodology Participants were recruited from the LESIONS programme in South‐East Queensland, Australia. Participants underwent both conventional oral examination (COE) of mucosal tissues as well as screening with OFI by trained dentists and oral health therapists (OHTs). Lesions were classified as homogeneous, non‐homogeneous, lichenoid or other. The study protocol included blanching of lesions detected with VELscope® (diascopy) and a two‐week review and reassessment of all lesions to reduce false‐positive findings. Analysis of decisions made by dentists and OHTs about lesion identification and triaging was undertaken. Results A total of 360 participants underwent both COE and OFI screening and presented with at least one lesion detected with either method. Lesion size increased and border distinctness and visibility improved with OFI. Of the 170 lesions that underwent two‐week reassessment, 70% resolved or were confirmed as benign. OHTs were more likely to request review and referral for OPMDs compared to dentists. Conclusion Optical fluorescence imaging is a useful tool to help dentists and OHTs identify and triage patients with possible OPMD in the primary care setting.

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“…Examples of commercial devices are already available in the USA. [22][23][24][25][26][27] Nowadays, new devices are proposing a combination of fluorescence with more techniques such as reflectance, 19 optical coherent tomography, 28 and fluorescence lifetime imaging. 29 It has to be pointed out that the majority of the studies performed until now still rely on clinical assessment by one or more doctors trained in this technique.…”

Section: Introductionmentioning

confidence: 99%

Automated algorithm for actinic cheilitis diagnosis by wide-field fluorescence imaging

et al. 2016

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Abstract. Actinic cheilitis (AC) is a disease caused by prolonged and cumulative sun exposure that mostly affects the lower lip, which can progress to a lip squamous cell carcinoma. Routine diagnosis relies on clinician experience and training. We investigated the diagnostic efficacy of wide-field fluorescence imaging coupled to an automated algorithm for AC recognition. Fluorescence images were acquired from 57 patients with confirmed AC and 46 normal volunteers. Three different algorithms were employed: two based on the emission characteristics of local heterogeneity, entropy and intensity range, and one based on the number of objects after K-mean clustering. A classification model was obtained using a fivefold cross correlation algorithm. Sensitivity and specificity rates were 86% and 89.1%, respectively.

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Assessment of a decision making protocol to improve the efficacy of VELscope™ in general dental practice: A prospective evaluation

Cited by 50 publications

References 33 publications

Medication-Related Osteonecrosis of the Jaw: An Autofluorescence-Guided Surgical Approach Performed with Er:YAG Laser

Medication-Related Osteonecrosis of the Jaw: An Autofluorescence-Guided Surgical Approach Performed with Er:YAG Laser

Usefulness of optical fluorescence imaging in identification and triaging of oral potentially malignant disorders: A study of VELscope in the LESIONS programme

Automated algorithm for actinic cheilitis diagnosis by wide-field fluorescence imaging

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