Assessment of a land-locked Atlantic salmon (Salmo salar L.) population as a potential genetic resource with a focus on long-chain polyunsaturated fatty acid biosynthesis

Betancor, Mónica B.; Olsen, Rolf Erik; Solstorm, David; Skulstad, Ole Fredrik; Tocher, Douglas R.

doi:10.1016/j.bbalip.2015.12.015

Cited by 21 publications

(40 citation statements)

References 59 publications

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“…LA supplementation, on the contrary, increased both elovl5b transcript abundance and 20:3n-3 production. A recent study suggested that land-locked salmon, which remain in freshwater their whole life and thus are naturally surrounded by lower levels of n-3 PUFA, might have a higher ∆8 activity compared to their farmed counterparts [53]. In the present study, radioactivity recovered in 20:4n-3 was significantly reduced in the PL fraction of cells by increasing levels of n-3 VLC-PUFA, and the addition of LA reduced it further.…”

Section: Discussionsupporting

confidence: 51%

“…Data are shown as mean ± SEM (n=6). Formatted ... [33] Formatted ... [34] Formatted ... [35] Formatted ... [36] Formatted ... [37] Formatted ... [38] Formatted ... [39] Formatted ... [40] Formatted ... [41] Formatted ... [42] Formatted ... [43] Formatted ... [44] Formatted ... [45] Formatted ... [46] Formatted ... [47] Formatted ... [48] Formatted ... [49] Formatted ... [50] Formatted ... [51] Formatted ... [52] Formatted ... [53] Formatted ... [54] Formatted ... [55] Formatted ... [56] Formatted ... [57] Formatted ... [58] Formatted ... [59] Formatted ... [60] Formatted ... [61] F o r P e e r R e v i e w 31 Table 78. Spearman's correlation coefficients between cellular EPA or cellular DHA and 18:3n-3 and its FA products in control hepatocytes and hepatocytes supplemented with lipoic acid.…”

Section: Discussionmentioning

confidence: 99%

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EPA, DHA, and Lipoic Acid Differentially Modulate the n‐3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes

Bou

Østbye

Berge

et al. 2017

Lipids

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

EPA, DHA, and Lipoic Acid Differentially Modulate the n‐3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes

Bou

Østbye

Berge

et al. 2017

Lipids

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“…Overall, while the aquaculture industry seeks to further stretch the optimization of fish feed production, the administration of isotopes will provide deeper insights into the regulation of lipid storage and oxidation in fish species in response to different combination of macronutrients. This may be particularly interesting in the procurement of new species to farm or in the optimization and selection of existing ones, currently happening by trait preference (Jin et al, 2014b;Song et al, 2018) or by recurring to the wide spectrum of metabolic responses occurring in nature (Betancor et al, 2016;Marandel et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Impact of dietary starch on extrahepatic tissue lipid metabolism in farmed European (Dicentrarchus labrax) and Asian seabass (Lates calcarifer)

Viegas

Trenkner

Rito

et al. 2019

Comparative Biochemistry and Physiology Part A: Molecular &

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In aquaculture, there is high interest in substituting marine-derived with vegetablebased ingredients as energy source. Farmed carnivorous fish under high carbohydrate diets tend to increase adiposity but it remains unclear if this happens by increased lipid retention/accumulation, promotion of lipogenic pathways, or both. In order to determine the response of extrahepatic tissue to dietary starch, European (Dicentrarchus labrax) and Asian (Lates calcarifer) seabass were fed a control (low starch; LS) or experimental (high starch; HS) diet, for at least 21 days and then transferred for 6 days to saltwater enriched with deuterated water 2 H2O. Incorporation of 2 H-labelling follows well-defined metabolic steps, and analysis of triacylglycerols (TAG) 2 H-enrichment by 2 H-NMR allowed evaluation of de novo lipogenesis (DNL) in muscle and visceral adipose tissue (VAT). Fractional synthetic rates for TAGbound fatty acids and glycerol were quantified separately providing a detailed lipogenic profile. The FA profile differed substantially between muscle and VAT in both species, but their lipogenic fluxes revealed even greater differences. In European seabass, HS promoted DNL of TAG-bound FA, in muscle and VAT. High 2 Henrichment also found in muscle TAG-bound glycerol was indicative of its role on lipid cycling. In Asian seabass, HS had no effect on muscle FA composition and lipogenic flux, with no 2 H-enriched TAG being detected. VAT on the other hand revealed a strong enhancement of DNL in HS-fed fish along with high TAG-bound glycerol cycling. This study consolidated the use of 2 H2O as tracer for fish lipid metabolism in different tissues, under different dietary conditions and suitable to use in different fish models.

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“…Comparing anadromous (semi-anadromous) and landlocked conspecific fish, it should be taken in account that land-locked populations may have a higher capacity of biosynthesis (conversion) of long-chain PUFA, EPA and DHA from short-chain n-3 precursor FA compared to that of anadromous populations [71,72]. For instance, this putative ability might partly explain the higher EPA + DHA content of land-locked C. lavaretus from the Sobachye Lake vs. the lower content of migratory C. lavaretus from the Keret River.…”

Section: Discussionmentioning

confidence: 99%

Fatty Acid Composition and Contents of Seven Commercial Fish Species of Genus Coregonus from Russian Subarctic Water Bodies

Gladyshev

Sushchik

Makhutova

et al. 2017

Lipids

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In several Russian northern lakes and rivers, Arctic cisco Coregonus autumnalis, least cisco C. sardinella, peled C. peled, tugun C. tugun, broad whitefish C. nasus, whitefish C. lavaretus and vendace C. albula were sampled in periods of officially permitted commercial fishery. Special attention was paid to contents (mg g of wet weight) of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in muscle tissues (filets), which are essential for human nutrition. The highest values of EPA + DHA content in semi-anadromous fish and freshwater fish were recorded for C. autumnalis from the Yenisei River, 17.60 mg g wet weight, and for C. lavaretus from the Sobachye Lake, 16.61 mg g wet weight, respectively. Intra-genus variations of EPA + DHA contents of Coregonus species were from 1.87 to 17.60 mg g wet weight. Since the congeneric species were genetically close to each other, the variations in EPA and DHA contents were thought to be caused primarily by ecological factors: migrational capability, type of feeding and trophic status of aquatic ecosystems. In general, the majority of studied species appeared to be of a high nutritive value for humans, although unfavorable environmental conditions could considerably diminish this value.

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Assessment of a land-locked Atlantic salmon (Salmo salar L.) population as a potential genetic resource with a focus on long-chain polyunsaturated fatty acid biosynthesis

Abstract: 24The natural food for Atlantic salmon (Salmo salar) in freshwater has relatively lower levels 25 of omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) than found in prey for

Cited by 21 publications

References 59 publications

EPA, DHA, and Lipoic Acid Differentially Modulate the n‐3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes

EPA, DHA, and Lipoic Acid Differentially Modulate the n‐3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes

Impact of dietary starch on extrahepatic tissue lipid metabolism in farmed European (Dicentrarchus labrax) and Asian seabass (Lates calcarifer)

Fatty Acid Composition and Contents of Seven Commercial Fish Species of Genus Coregonus from Russian Subarctic Water Bodies

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