2001
DOI: 10.1016/s0091-3057(01)00600-1
|View full text |Cite
|
Sign up to set email alerts
|

Assessment of acute and chronic morphine dependence in male and female mice

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

5
67
0

Year Published

2005
2005
2023
2023

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 67 publications
(72 citation statements)
references
References 31 publications
5
67
0
Order By: Relevance
“…Among withdrawal measures, only the jumping response-defined as the simultaneous removal of all four paws from the horizontal surface-was consistently observed and found to be dose-dependent in previous studies of both acute and chronic morphine dependence (Smits, 1975;El-Kadi and Sharif, 1994;Kest et al 2001). Thus, although symptoms such as diarrhea, ptosis, wet-dog shakes, lacrimation were occasionally observed in the present study, they were excluded from analysis.…”
Section: Naloxone-precipitated Withdrawalsupporting
confidence: 47%
See 1 more Smart Citation
“…Among withdrawal measures, only the jumping response-defined as the simultaneous removal of all four paws from the horizontal surface-was consistently observed and found to be dose-dependent in previous studies of both acute and chronic morphine dependence (Smits, 1975;El-Kadi and Sharif, 1994;Kest et al 2001). Thus, although symptoms such as diarrhea, ptosis, wet-dog shakes, lacrimation were occasionally observed in the present study, they were excluded from analysis.…”
Section: Naloxone-precipitated Withdrawalsupporting
confidence: 47%
“…For narcotic drug abusing populations, the aversive withdrawal symptomology is regarded as a causative factor in their continued opioid use, engendering dangerous drug seeking behavior (Jasinski, 1977). Although physical dependence is commonly associated with chronic opioid intake, acute opioid treatment comprised of even a single exposure can cause dependence in a wide variety of species (Smits, 1975;Jasinski, 1977;McLemore et al 1997;Kest et al 2001). Despite their qualitatively similar withdrawal symptoms, there is behavioral and biochemical evidence that acute and chronic dependence are mediated by distinct mechanisms (Nehmad et al 1982;McLemore et al 1997;Kest et al 2001).…”
Section: Introductionmentioning
confidence: 99%
“…It has been suggested that frequency is the most important factor (29). In studies with daily morphine injections, animals receive each dose at equal (6,18,25,30) or unequal dosing intervals (6,13,15,31). In the present study, animals were given intermittent morphine injections with different interdose intervals for a better assessment of spontaneous withdrawal associated to the treatment regimen.…”
Section: Discussionmentioning
confidence: 93%
“…Weight loss and jumping are considered predominant signs for quantification of naloxone withdrawal in both rats (33,34) and mice (6,11,35). Accordingly, naloxone precipitated withdrawal weight loss and jumping in morphine-treated male and female rats (Figures 1 and 2).…”
Section: Discussionmentioning
confidence: 95%
See 1 more Smart Citation