Assessment of Additional Risk Factors for Cardiovascular Disease and Awareness Among Adult Patients With Diabetes Mellitus: A Cross-Sectional Study From Northern Sri Lanka

Manoharan, Printhiny; Rajeshkannan, Nadarajah; Suganthan, Navaneethakrishnan

doi:10.7759/cureus.30047

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Since type 2 diabetes mellitus is a frequent and spreading condition, it is a signi icant global public health issue. According to the International Diabetes Federation, 387 million individuals worldwide have been diagnosed with diabetes [7].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Oral Hypoglycaemics in Type-2 Diabetes Mellitus Patients at a Tertiary Care Hospital : A Comparative Observational Study

Arun¹

2022

Fut J. Pharm & H. Sci

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Hyperglycemia, or a state of high blood sugar, is a symptom of diabetes mellitus (D.M.), a complicated chronic disease brought on by deficits in insulin production, activity, or both. Since type 2 diabetes mellitus is a frequent and spreading condition, it is a significant global public health issue. The International Diabetes Federation estimates that 629 million people will have diabetes by 2045, up from the current 425 million cases. The main objective is to compare the effectiveness of oral hypoglycaemics in Type-2 Diabetes Mellitus patients at a tertiary care hospital. This prospective observational study was carry out for six months at HKES’s Basaveshwar Teaching and General Hospital, Kalaburagi. Patients were enrolled based on eligibility criteria. Study populations of 120 subjects with incident Type 2 Diabetes Mellitus were enrolled. Among 120 issues, 25 (20.83%), 15 (12.5%), and 20 (16.66%) subjects are under the treatment of Biguanides, Sulfonylureas, and DPP-4 Inhibitors. 10 (8.33%), 30 (25%) and 20 (16.66%) subjects are under the treatment of Biguanides and Sulfonylureas combination, Biguanides and DPP-4 Inhibitors combination and Biguanides, Sulfonylureas and DPP-4 Inhibitors combination. Finally, conclude that the DPP4 Inhibitor combination group of drugs is better than other anti-diabetic medications in maintaining good glycemic status in type 2 D.M. patients, particularly Biguanides+DPP-4 Inhibitors and then followed by Biguanides+DPP-4 Inhibitors + Sulfonylureas by comparing all the laboratory values obtained.

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Section: Introductionmentioning

confidence: 99%

Effectiveness of Oral Hypoglycaemics in Type-2 Diabetes Mellitus Patients at a Tertiary Care Hospital : A Comparative Observational Study

Arun¹

2022

Fut J. Pharm & H. Sci

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Machine learning-based models to predict one-year mortality among Chinese older patients with coronary artery disease combined with impaired glucose tolerance or diabetes mellitus

Li¹,

Guan

Ning

et al. 2023

Cardiovasc Diabetol

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Purpose An accurate prediction of survival prognosis is beneficial to guide clinical decision-making. This prospective study aimed to develop a model to predict one-year mortality among older patients with coronary artery disease (CAD) combined with impaired glucose tolerance (IGT) or diabetes mellitus (DM) using machine learning techniques. Methods A total of 451 patients with CAD combined with IGT and DM were finally enrolled, and those patients randomly split 70:30 into training cohort (n = 308) and validation cohort (n = 143). Results The one-year mortality was 26.83%. The least absolute shrinkage and selection operator (LASSO) method and ten-fold cross-validation identified that seven characteristics were significantly associated with one-year mortality with creatine, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and chronic heart failure being risk factors and hemoglobin, high density lipoprotein cholesterol, albumin, and statins being protective factors. The gradient boosting machine model outperformed other models in terms of Brier score (0.114) and area under the curve (0.836). The gradient boosting machine model also showed favorable calibration and clinical usefulness based on calibration curve and clinical decision curve. The Shapley Additive exPlanations (SHAP) found that the top three features associated with one-year mortality were NT-proBNP, albumin, and statins. The web-based application could be available at https://starxueshu-online-application1-year-mortality-main-49cye8.streamlitapp.com/. Conclusions This study proposes an accurate model to stratify patients with a high risk of one-year mortality. The gradient boosting machine model demonstrates promising prediction performance. Some interventions to affect NT-proBNP and albumin levels, and statins, are beneficial to improve survival outcome among patients with CAD combined with IGT or DM.

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Assessment of Additional Risk Factors for Cardiovascular Disease and Awareness Among Adult Patients With Diabetes Mellitus: A Cross-Sectional Study From Northern Sri Lanka

Cited by 2 publications

References 24 publications

Effectiveness of Oral Hypoglycaemics in Type-2 Diabetes Mellitus Patients at a Tertiary Care Hospital : A Comparative Observational Study

Effectiveness of Oral Hypoglycaemics in Type-2 Diabetes Mellitus Patients at a Tertiary Care Hospital : A Comparative Observational Study

Machine learning-based models to predict one-year mortality among Chinese older patients with coronary artery disease combined with impaired glucose tolerance or diabetes mellitus

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