Assessment of Adnexal Masses by Transvaginal Sonography and Serum CA125 Assay in Pre- and Postmenopausal Women

Banu, Selina Akhter; Khatun, Sabera; Shamsuddin, L.

doi:10.3329/bjog.v24i2.8529

Cited by 1 publication

(3 citation statements)

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“…This is similar to the results shown in other studies and therefore warrants use of CA-125 routinely in such patients with aggressive search for malignant etiology in these patients. [12][13][14][15][16] However, given higher incidence of malignant etiology and lower negative predictive value of CA-125 levels in post-menopausal women a thorough work up for malignant disease is mandatory even with normal CA-125 levels. [12][13][14][15][16] A good sensitivity and negative predictive value of CA-125 in premenopausal women was seen in our study.…”

Section: Discussionmentioning

confidence: 99%

“…This is also consistent with previous studies done so far. [12][13][14][15][16] Normal CA-125 levels in premenopausal and younger women therefore almost rule out a malignant etiology.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have combined the use of serum CA-125 levels and doppler ultrasonography parametres (like mean pulsitality index and mean resistivity index) for evaluation of adnexal masses and ruling out malignant diseases. [12][13][14][15][16] Individual investigations have also been compared with each other in many studies with most of the studies showing color doppler evaluation to be more specific in diagnosing malignancy as compared to the CA-125 levels. 13,14 The combination of the two tests is also more specific than CA-125 levels.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Role of cancer antigen-125 in diagnosing malignant adnexal masses: a prospective observational study

Khan

Rahi

Khan

2020

Int J Reprod Contracept Obstet Gynecol

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Background: Adnexal masses present a diagnostic and therapeutic dilemma across age-groups. This study aimed to evaluate the performance of cancer antigen-125 (CA-125) in distinguishing between benign and malignant adnexal masses.Methods: This was a prospective, observational, single tertiary-care center study, done in North India from January, 2011 till December, 2012. Serum CA-125 levels was obtained preoperatively in consecutive patients presenting with ultrasonography confirmed adnexal masses. The cut-off value between benign and malignant was taken as 35 IU/ml. Histopathological diagnosis was obtained in all patients.Results: A total of 126 patients presented with adnexal masses, of which 100 were enrolled (mean age: 37.5±14.4 years, range: 18-80 years). Most of the masses were benign 81% (malignant=19%). Dermoid cyst (25.9%) and endometriomas (21%) were the most common benign masses. Serous (21%) and mucinous cystadeno-carcinoma (15.8%) were the most common malignant masses, more often seen in elderly, married, parous and post-menopausal patients. Mean CA-125 levels were significantly higher in malignant masses (257.30 [105.68-408.92] versus 19.26 [16.53-22.00], p<0.001). Overall sensitivity, specificity, positive predictive value, negative predictive value and accuracy of CA-125 for diagnosing malignant adnexal mass was 94.7%, 87.65%, 64.28%, 98.6%, and 88.91% respectively. The same was 100%, 85.1%, 54.5%, 100%, 87.3% in premenopausal and 85.7%, 100%, 100%, 93.3%, 95.2% in postmenopausal women respectively.Conclusion: Benign masses form the bulk of the adnexal masses in all age groups. CA-125 levels has high sensitivity and negative predictive value in premenopausal patients while as high specificity and positive predictive value in postmenopausal patients.

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Section: Discussionmentioning

confidence: 99%

“…This is also consistent with previous studies done so far. [12][13][14][15][16] Normal CA-125 levels in premenopausal and younger women therefore almost rule out a malignant etiology.…”

Section: Discussionmentioning

confidence: 99%