Assessment of aerobic exercise capacity in obesity, which expression of oxygen uptake is the best?

Zhou, Na

doi:10.1016/j.smhs.2021.01.001

Cited by 13 publications

(10 citation statements)

References 157 publications

(316 reference statements)

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“…Higher levels of physical activity are important for weight maintenance and increasing fitness, and higher fitness may reduce some of the harmful cardiometabolic effects of obesity 62 . Differences between the associations of fitness and cancer by scaling are likely driven by the different components of fitness, as VO 2 max tbm has a strong inverse correlation with body size and adiposity 25 . However, the complex interplay of adiposity, fitness and cancer might mean that accounting for adiposity for models of cardiorespiratory fitness could lead to an over-adjustment of risk estimates, but these relationships are difficult to disentangle.…”

Section: Discussionmentioning

confidence: 99%

“…23, 24 VO2maxffm represents the ability of skeletal muscle to use oxygen during maximal exercise, whereas VO2maxtbm is more representative of aerobic performance capacity. 25…”

Section: Methodsmentioning

confidence: 99%

“…23,24 VO2maxffm represents the ability of skeletal muscle to use oxygen during maximal exercise, whereas VO2maxtbm is more representative of aerobic performance capacity. 25 Genetic instrument for cardiorespiratory fitness Full details of the fitness genome-wide association study (GWAS) are available elsewhere. 19 In brief, single nucleotide polymorphisms (SNPs) associated with fitness were identified from a GWAS based on UK Biobank participants of European ancestry who participated in the fitness test (N included=69,416).…”

Section: Uk Biobank Cardiorespiratory Fitness Assessmentmentioning

confidence: 99%

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Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study

Watts¹,

Gonzales

Strain

et al. 2023

Preprint

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Importance: The association of cardiorespiratory fitness with cancer risk is not clear. Objective: To investigate whether fitness is associated with the risk of diagnosis of common cancers. Design, setting, and participants: In observational analyses, we used multivariable-adjusted Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of cancer in a subset of UK Biobank participants who completed a submaximal fitness test in 2009-12 (N=72,572). In secondary analyses, we used a two-sample Mendelian randomization (MR) framework, with genetically predicted fitness as an instrumental variable derived from UK Biobank study participants and genetic cancer data from international consortia. Odds ratios (ORs) were estimated using the inverse-variance weighted method. Relationships between fitness and cancer may be partially mediated by adiposity, and therefore associations were estimated with and without adjustment for adiposity. Exposures: Estimated maximal cardiorespiratory fitness (ml O2⋅min-1⋅kg-1 total-body mass and ml O2⋅min-1⋅kg-1 fat-free mass). Main outcomes and measures: Diagnosis of lung, colon, rectal, endometrial, female breast, and prostate cancer. MR analyses additionally included pancreatic and renal cancers. Results: After a median of 11 years of follow-up, 4,290 cancers of interest were diagnosed. A 3.5 ml O2⋅min-1⋅kg-1 total-body mass increase in fitness (approximately 0.5 standard deviation (SD)) was associated with lower risks of endometrial (HR=0.81, 95% CI 0.73-0.89), colorectal (0.94, 0.90-0.99), and breast cancer (0.96, 0.92-0.99). In MR analyses, higher levels of genetically predicted fitness were associated with a lower risk of breast cancer (OR per genetically predicted 0.5 SD increase in ml O2⋅min-1⋅kg-1 fat-free mass=0.92, 95% CI 0.86-0.98), including estrogen receptor (ER)+ (0.91, 0.84-0.99) and ER- (0.88, 0.80-0.97) subtypes. After adjusting for body fat, both the observational and genetic associations were attenuated. Conclusions and relevance: Higher fitness levels may reduce risks of endometrial, colorectal, and breast cancer, though relationships with adiposity are complex and may mediate these relationships. Aiming to increase fitness, including via changes in body composition, may be an effective strategy for cancer prevention.

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Section: Discussionmentioning

confidence: 99%

“…23, 24 VO2maxffm represents the ability of skeletal muscle to use oxygen during maximal exercise, whereas VO2maxtbm is more representative of aerobic performance capacity. 25…”

Section: Methodsmentioning

confidence: 99%

Section: Uk Biobank Cardiorespiratory Fitness Assessmentmentioning

confidence: 99%

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Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study

Watts¹,

Gonzales

Strain

et al. 2023

Preprint

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“…33 Excessive fat mass imposes an unfavorable burden on cardiac function and working muscle, indirectly decreasing exercise capacity. 34 Increased fat puts pressure on the chest wall and abdomen, leading to inefficient ventilatory work, 35 which is associated with reduced exercise capacity.…”

Section: Discussionmentioning

confidence: 99%

The relationship between skeletal muscle mass and exercise capacity in patients undergoing hemodialysis: An exploratory secondary‐analysis

Zhang,

Zhuang,

Qin

et al. 2023

Hemodialysis International

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BackgroundProtein‐energy wasting is commonly observed in patients undergoing hemodialysis, leading to reduced muscle mass and, in severe cases, sarcopenia, which significantly impacts the patients' quality of life and clinical outcomes. Exercise interventions are frequently employed to address muscle loss in these patients. However, the relationship between exercise capacity and skeletal muscle mass in this context remains uncertain. In this study, researchers conducted a series of body composition analysis and exercise capacity test to explore the relationship between exercise capacity and skeletal muscle mass.MethodsThis study recruited 32 patients undergoing hemodialysis and analyzed their demographic and clinical parameters. To assess aerobic exercise capacity, the incremental shuttle walking test (ISWT) was conducted, while the handgrip strength test was used to evaluate muscle strength. The patients' body compositions were assessed using the Fresenius Body Composition Monitor, and the appendicular skeletal muscle was scanned using a GE Healthcare Lunar iDXA scanner. Three sequential linear models were employed to model the relationship between ISWT and skeletal muscle mass. Model 1 regressed ISWT against gender and age; Model 2 added handgrip strength, fat tissue index, and Davies comorbidity scores as additional predictors; and Model 3 further included the appendicular skeletal muscle index (appendicular skeletal muscle/height).FindingsAfter controlling for age and gender (Model 1: R2 = 0.373), and subsequently including handgrip strength, fat tissue index, and Davies comorbidity score effects (Model 2: R2 = 0.581), the impact of appendicular skeletal muscle on ISWT was found to be non‐significant (Model 3: R2 = 0.600).ConclusionThere was no significant correlation observed between exercise capacity and skeletal muscle mass in patients undergoing hemodialysis, indicating the factors influencing exercise capacity in this patient population are complex and that increasing skeletal muscle mass may not necessarily involve solely addressing the improvement of exercise capacity.

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“…If the recovery period is relatively brief and remains elevated until the next sprint, aerobic metabolism will be used instead to generate adenosine triphosphate. 2 High-intensity movements, such as rapid changes in direction, speed, and repetitive jumps, are considered key elements of successful performance in basketball games. 3 High-intensity interval training is a training method that can improve anaerobic and aerobic capacity at the same time, high-intensity interval training can increase the activity of glycolysis and oxidative enzymes at the same time, enhancement of short-duration high-intensity exercise performance and VO2 max, the reason for these adaptations is that the intermittent approach reduces the contribution of anaerobic metabolism to ATP production, improves the contribution of aerobic metabolism to energy production, interspersed with recovery periods between high-intensity exercise periods, the aerobic metabolic pathway promotes the oxidation of lactate and the resynthesis of creatine phosphate, thereby enhancing the ability of the aerobic energy metabolism system.…”

Section: Introductionmentioning

confidence: 99%

Effects of High-Intensity Training on Basketball Players

Jiang

2023

Rev Bras Med Esporte

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Introduction: Basketball represents much more than a high-intensity exercise. Like most ball games, it is a continuous movement system. Objective: Study the effect of high-intensity interval training (HIT) on the aerobic metabolism of young basketball players. Methods: The author randomly divided male basketball players into an upper limb HIT group, lower limb HIT group, and control group by experimental method and statistical analysis, the control group received routine training, and aerobic exercise capacity was measured by increasing load test before and after the experiment. Results: During the lower extremity experiment, the mean power (MP) and peak power (PP) of the 4th full-force pedal stroke in the lower extremity HIT group increased (P<0.05), and the T/C ratio of the lower extremity HIT group was also implemented (P<0.05). There was no significant change in the indices of the control group (P>0.05). Conclusion: Upper extremity HIT in young male basketball players improved only upper extremity aerobic exercise capacity. In contrast, lower-extremity HIT improved both upper-extremity aerobic exercise capacity and lower-extremity anaerobic exercise capacity. Level of evidence II; Therapeutic studies - investigating treatment outcomes.

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Assessment of aerobic exercise capacity in obesity, which expression of oxygen uptake is the best?

Cited by 13 publications

References 157 publications

Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study

Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study

The relationship between skeletal muscle mass and exercise capacity in patients undergoing hemodialysis: An exploratory secondary‐analysis

Effects of High-Intensity Training on Basketball Players

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