Assessment of agreement and time in therapeutic range of capillary versus venous international normalised ratio in frail elderly people in a nursing home

Abstract

Vitamin K antagonists are widely used, yet have a slim therapeutic margin and high iatrogenicity. Patients are monitored through international normalised ratio (INR) by venipuncture, but coagulometers could measure INR by capillary puncture. This prospective study evaluated the clinical concordance of capillary INR versus venous INR in 31 nursing home patients. Concordance was good and mean time in therapeutic range (TTR) markedly increased. Capillary INR is thus reliable, could improve TTR and decrease iatrogenicity.

Association between ribociclib and changes in creatinine in patients with hormone receptor positive metastatic breast cancer

“…Despite this, pharmacokinetic studies have shown that no dose adjustments are required for patients with mild to moderately elevated creatinine at baseline, as the predominant route for drug excretion is faecal. 14 Based on our experience to date, we have developed recommendations for investigation and management of creatinine rises in patients on combination ribociclib and aromatase inhibitors ( Table 2).…”