Assessment of allergenicity of irradiated dairy products in a Balb/c mice model

Miteva, Daniela A.; Solak, Ayten; Dyankova, S.; Nacheva, I.; Dimov, K.

doi:10.3897/pharmacia.67.e53886

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…No benefits were observed in the use of frog skin as a biological dressing on the healing of integumentary wounds produced in dogs [31], however, the authors did not use any method to alter the antigenicity of the xenograft, such as the gamma radiation used in the current study and by Adorno (2005) [11]. The use of gamma rays reduces antigenicity to food proteins and allergenicity [32].…”

Section: Discussionmentioning

confidence: 87%

Evaluation of Bacterial Cellulose/Alginate-Based Hydrogel with Frog Skin, in Wound Healing in Horses

Oliveira,

Fagundes,

Fortes

et al. 2024

Preprint

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We evaluated the macroscopic and histopathological aspects of skin healing by secondary intention in equine wounds, surgically induced and topically treated with bacterial cellulose hydrogel with alginate (BCAG) or frog skin (FSG), compared with ringer lactate (CG). Three wounds were created on each side of the lumbar region, one side for gross evaluation with photos and measurement of the area and contraction rate and the other for histopathological evaluation, with the sides selected randomly, in 5 horses. All wounds received daily treatment, and clinical and histopathological evaluations were conducted on postoperative days 0, 3, 7, 14, 21, and 28. Although no statistical differences were observed, the BCAG presented a reduced wound area and a high wound contraction percentage on days 14 and 21. At 28 days, the average contraction rates were 96.08%, 92.87%, and 88.6% for the CG, BCAG, and FSG, respectively. Although there was no statistical difference between the groups in wound healing in this study in horses, in clinical evaluations an early start of filling the area of the wounds treated with frog skin was observed, and on D14 and D21, a smaller area and higher contraction rate were observed in BCAG, which can be attributed to more efficient re-epithelialization and fibroblast proliferation.

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Section: Discussionmentioning

confidence: 87%

Evaluation of Bacterial Cellulose/Alginate-Based Hydrogel with Frog Skin, in Wound Healing in Horses

Oliveira,

Fagundes,

Fortes

et al. 2024

Preprint

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“…Several studies have indicated that ionizing radiation could reduce allergenicity by the destruction of human IgE-binding epitopes in milk allergens depending on the dose of irradiation [ 99 ]. A study assessing the allergenicity of irradiated dairy products in BALB/c mice revealed that gamma irradiation influenced the epitopes of the major milk proteins and was associated with lower allergenicity of lyophilized irradiated milk [ 100 ]. In line with this, another study, investigating ultrasound-assisted irradiation for reducing the allergenicity of β-lactoglobulin, revealed that IgE binding capacity and release of inflammatory mediators from human basophil cells were reduced significantly [ 69 ].…”

Section: Food Processing: Applied Techniques and Effect On The Allmentioning

confidence: 99%

Cow’s Milk Processing—Friend or Foe in Food Allergy?

Geiselhart

Podzhilkova

Hoffmann‐Sommergruber

2021

Foods

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Cow’s milk (CM) is an integral part of our daily diet starting in infancy and continuing throughout our lifetime. Its composition is rich in proteins with a high nutritional value, bioactive components, milk minerals including calcium, and a range of immunoactive substances. However, cow’s milk can also induce a range of immune-mediated diseases including non-IgE-mediated food allergies and IgE-mediated food allergies. Cow’s milk allergens have been identified and characterized and the most relevant ones can be assigned to both, the whey and casein fraction. For preservation a range of processing methods are applied to make cow’s milk and dairy products safe for consumers. However, these methods affect milk components and thus alter the overall immunogenic activity of cow’s milk. This review summarizes the current knowledge on cow’s milk allergens and immunoactive substances and the impact of the different processes up- or downregulating the immunogenicity of the respective proteins. It highlights the gaps of knowledge of the related disease mechanisms and the still unidentified beneficial immunomodulating compounds of cow’s milk.

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