2021
DOI: 10.1001/jamanetworkopen.2021.3486
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Assessment of an Exhaled Breath Test Using High-Pressure Photon Ionization Time-of-Flight Mass Spectrometry to Detect Lung Cancer

Abstract: IMPORTANCE Exhaled breath is an attractive option for cancer detection. A sensitive and reliable breath test has the potential to greatly facilitate diagnoses and therapeutic monitoring of lung cancer.OBJECTIVE To investigate whether the breath test is able to detect lung cancer using the highly sensitive high-pressure photon ionization time-of-flight mass spectrometry (HPPI-TOFMS). DESIGN, SETTING, AND PARTICIPANTSThis diagnostic study was conducted with a prospectivespecimen collection, retrospective-blinded… Show more

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Cited by 36 publications
(40 citation statements)
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“…The breath collection protocol has been thoroughly reported. 21 , 22 Briefly, all exhaled breath samples were collected by trained investigators using prepared Tedlar (DuPont de Nemours) air bags. On the night before breath collection, the Tedlar bags were baked at 60 °C for 3 h to fully release possible contaminants and continuously purged with high-purity nitrogen four times.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The breath collection protocol has been thoroughly reported. 21 , 22 Briefly, all exhaled breath samples were collected by trained investigators using prepared Tedlar (DuPont de Nemours) air bags. On the night before breath collection, the Tedlar bags were baked at 60 °C for 3 h to fully release possible contaminants and continuously purged with high-purity nitrogen four times.…”
Section: Methodsmentioning
confidence: 99%
“… 20 We have preliminarily confirmed the application of HPPI-TOFMS in exhaled breath testing for lung cancer and esophageal cancer detection in cross-sectional studies. 21 , 22 …”
Section: Introductionmentioning
confidence: 99%
“…The self-designed sampling equipment including a CO 2 sensor was used for breath sampling as previously reported. 14 The CO 2 sensor was used to ensure that alveolar air was collected: exhaled breath collection began once the CO 2 sensor detected a CO 2 concentration exceeding 4%. All air bags were delivered to the laboratory and detected within 4 hours.…”
Section: Methodsmentioning
confidence: 99%
“…13 To simplify breathomics testing procedures and increase the robustness of breathomics results, we substantially optimized direct online mass spectrometry and highpressure photon ionization time-of-flight mass spectrometry (HPPI-TOFMS) and established standardized breath sampling procedures. 14 In this study, we postulate that patients with esophageal cancer might have distinct breathomics and that testing breathomics using HPPI-TOFMS could offer a noninvasive, feasible, and accurate triage test for esophageal cancer detection.…”
Section: Introductionmentioning
confidence: 96%
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