Assessment of Ankaferd Blood Stopper in experimental liver ischemia reperfusion injury

Abstract

Background/aim: To investigate possible protective effects of Ankaferd Blood Stopper® (ABS) in an experimental liver ischemia reperfusion injury (IRI) model. Materials and methods: The study was carried out on 30 female rats separated into 3 groups as sham, control (IRI), and treatment (IRI + ABS) groups. In the IRI + ABS group, 0.5 mL/day ABS was given for 7 days before surgery. In the IRI and IRI + ABS groups, the hepatic pedicle was clamped for 30 min to apply ischemia. Then, after opening the clamp, 90-min reperfusion of the liver was provided. Blood and liver tissue samples were taken for biochemical and histopathological analyses. Results: Compared to the sham group, the IRI group had significantly higher levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total oxidant status (TOS), malondialdehyde (MDA), fluorescent oxidant products (FOP) and lower expression of albumin and total antioxidant status (TAS) (P < 0.05). Compared to the IRI group, the IRI+ABS group showed lower expression of AST, ALT, TOS, MDA and FOP and higher expression of albumin and TAS (P < 0.05). In the histopathological analysis, congestion scores were statistically significantly lower in the IRI + ABS group than in the IRI group. Conclusions: ABS has a strong hepatoprotective effect due to its antioxidant and antiinflammatory effects and could therefore be used as a potential therapeutic agent for IRI.

Drug interaction potential of Ankaferd blood stopper® in human hepatocarcinoma cells

“…In addition to its hemostatic effect, ABS is known to have antiinflammatory, antioxidant, and antibacterial activities due to its components [ 30 – 32 ]. ABS also has a strong hepatoprotective feature due to its antioxidant and antiinflammatory properties [ 29 , 50 ].…”

“…ABS is a standard mixture of Alpinia officinarum , Gycyrrhiza glabra , Vitis vinifera , Thymus vulgaris , and Urtica dioica [ 23 – 26 ]. The herbs found in ABS can affect angiogenesis, blood cells, endothelial cells, and cellular proliferation [ 22 , 24 , 25 , 27 – 29 ]. Additionally, ABS is known to have antifungal, antiinflammatory, antioxidant, and antibacterial activities [ 30 – 32 ].…”

Protective Role of Ankaferd Blood Stopper on Cadmium-Induced Acute Nephrotoxicity

“…Koşmaz and Durhan suggested that ABS could mitigate experimental liver damage via its anti-inflammatory and antioxidant properties(40). Buyuktiryaki et al found that ABS ameliorates necrotizing enterocolitis by suppressing apoptotic factors(41).…”