Assessment of Anti-Anemic Effects of Saccharum Munja Roxb Roots Extract

Abstract

Anticancer agents often cause bone marrow suppression resulting in progressive anemia which may influence the therapeutic effects of different cancer treatment. Objective: The objective of this study was to evaluate, effects of ethanolic extract of Saccharum munja roxb (Kaana or Sirkanda) on hemoglobin and red blood cells counts suppressed by carboplatin. Methodology: Anemia was induced in mice with a single iv dose of 50 mg/kg carboplatin. Hematological responses including, RBC and Hb was measured at 3rd, 5thand 8th day. Saccharum munja roxbethanolicextract with dose of 25mg/kg, 50mg/kg and 100mg/kg were given to different treatment groups. Results: In the low dose (R. ext 25mg/kg) group hemoglobin level was found to be 11g/dl on 8thday. However (R.ext 50mg/kg) showed more improvement in hemoglobin levels i.e11.5 g/dl at 8th day. The mice treated with higher doses of extract (R.ext100mg/kg) showed major improvement in hemoglobin levels at 8th day which was 12.6g/dl.RBC count increased after oral administration of Saccharummunja extract (R.ext 25mg/kg) to 6.4 ×106cells /mm3 on 8thday. However, in (R.ext 50mg/kg) extract treated group RBC count was found to be 6.9 × 106cells /mm3 on 8thday. In (R.ext 100mg/kg) treated group the RBC count was 7.4 × 106 /mm3 on 8thday. Conclusion: Thus, the results suggested that ethanolic-extract ofSaccharum munja roxb at different dosesshow beneficial effects in improving different parameters of blood.This study also appropriately described the time course of hematological changes after carboplatin induced anemia in mice. Therefore, this study method can be useful tool to explore potential strategies for the management of anemia caused by chemotherapeutic agents. Keywords: Carboplatin, heamoglobin, Saccharummunja