Assessment of antibiotic prescribing patterns at dental and primary health care clinics according to WHO Access, Watch, Reserve (AWaRe) classification

Alshareef, Hanan; Alanazi, Amal; Alatawi, Norah; Eleshmawy, Nehal; Ali, Mostafa A. Sayed

doi:10.1016/j.ajic.2022.07.009

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Another US national outpatient survey study showed that about 23% of children with pharyngitis who were prescribed with antibiotics did not actually need them 4. Evidence also showed that children with ARIs were more likely to be prescribed with antibiotics, including broad-spectrum antibiotics, than children with other diseases 5 6. Most ARIs in children are caused by viruses, and antibiotic therapy is ineffective in shortening the course of the disease and reducing complications 7.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic prescription for children with acute respiratory tract infections in rural primary healthcare in Guangdong province, China: a cross-sectional study

He,

Li,

Wang

et al. 2023

BMJ Open

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ObjectivesThe objective of this study is to understand the characteristics and patterns of the first antibiotic prescriptions for children with acute respiratory infections (ARIs) in rural primary healthcare (PHC) in Guangdong province, China.DesignCross-sectional study.Setting and participantsWe used prescription data generated from the electronic medical record system of 37 township hospitals in two counties of Shaoguan City, Guangdong province. 46 699 first prescriptions for ARIs in children aged 0–18 years were screened from 444 979 outpatient prescriptions recorded between November 2017 and October 2018.Outcome measuresDescriptive analyses were used to report sociodemographic characteristics and antibiotic prescribing profiles. χ2analysis and binary logistic regression were used to analyse the factors associated with antibiotic prescriptions in children.ResultsOf the 46 699 sampled cases, 83.00% (n=38 759) received at least one antibiotic as part of their first prescription. Of the 38 759 sampled cases treated with antibiotics, 40.76% (n=15 799), 56.15% (n=21 762) and 31.59% (n=12 244) received parenteral antibiotics, broad-spectrum antibiotics and two or more kinds of antibiotics, respectively. Multivariable analysis showed that children aged ≤5 years were less likely to be prescribed with antibiotics than those aged 16–18 years (OR 0.545, p<0.001). Those with health insurance were more likely to be prescribed with antibiotics than those without health insurance (OR 1.677, p<0.001).ConclusionsMisuse and overuse of antibiotics were found in the prescriptions of children with ARIs in rural PHC. Antibiotic stewardship programme should be established to reduce the level of antibiotic prescriptions among children with ARIs in rural PHC, especially regarding the prescriptions of broad-spectrum antibiotics and parenteral antibiotics, tailored to different ages, sex and health insurance groups.

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Section: Introductionmentioning

confidence: 99%

Antibiotic prescription for children with acute respiratory tract infections in rural primary healthcare in Guangdong province, China: a cross-sectional study

He,

Li,

Wang

et al. 2023

BMJ Open

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Ciprofloxacin and Norfloxacin Hybrid Compounds: Potential Anticancer Agents

Peter,

Aderibigbe

2024

CTMC

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Background:: The concept of utilizing drug repurposing/repositioning in the development of hybrid molecules is an important strategy in drug discovery. Fluoroquinolones, a class of antibiotics, have been reported to exhibit anticancer activities. Although anticancer drug development is achieving some positive outcomes, there is still a need to develop new and effective anticancer drugs. Some limitations associated with most of the available anticancer drugs are drug resistance and toxicity, poor bio-distribution, poor solubility, and lack of specificity, which hamper their therapeutic outcomes. Objectives:: Fluoroquinolones, a known class of antibiotics, have been explored by hybridizing them with other pharmacophores and evaluating their anticancer activity in silico and in vitro. Hence, this review provides an update on new anticancer drugs development containing fluoroquinolones moiety, Ciprofloxacin and Norfloxacin between 2020 and 2023, their structural relationship activity, and the future strategies to develop potent chemotherapeutic agents. Methods:: Fluoroquinolones were mostly hybridized via the N-4 of the piperazine ring on position C-7 with known pharmacophores characterized, followed by biological studies to evaluate their anticancer activity. Results:: The hybrid molecules displayed promising and interesting anticancer activities. Factors such as the nature of the linker, the presence of electron-withdrawing groups, nature, and position of the substituents influenced the anticancer activity of the synthesized compounds Conclusion:: The hybrids were selective towards some cancer cells. However, further in vivo studies are needed to fully understand their mode of action

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Assessment of antibiotic prescribing patterns at dental and primary health care clinics according to WHO Access, Watch, Reserve (AWaRe) classification

Cited by 2 publications

References 29 publications

Antibiotic prescription for children with acute respiratory tract infections in rural primary healthcare in Guangdong province, China: a cross-sectional study

Antibiotic prescription for children with acute respiratory tract infections in rural primary healthcare in Guangdong province, China: a cross-sectional study

Ciprofloxacin and Norfloxacin Hybrid Compounds: Potential Anticancer Agents

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