Assessment of Antimicrobial and Antioxidant Activities of Nepeta trachonitica: Analysis of Its Phenolic Compounds Using HPLC-MS/MS

Köksal, Ekrem; Tohma, Hatice; Kılıç, Ömer; Alan, Yusuf; Aras, Abdülmelik; Gülçın, İlhami; Bursal, Ercan

doi:10.3390/scipharm85020024

Cited by 81 publications

(59 citation statements)

References 59 publications

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“…These hydroxylated phenolic compounds have many effects like antimutagenic, antiviral, and antioxidant (Aras, Dogru, & Bursal, ). Antioxidants are thought to be reason for preventing or lowering cardiovascular diseases, cancer risk, brain dysfunction, and cataracts (Bursal, ; Köksal et al, ).…”

Section: Resultsmentioning

confidence: 99%

Phytochemical content, antioxidant activity, and enzyme inhibition effect ofSalvia eriophoraBoiss. & Kotschy against acetylcholinesterase, α-amylase, butyrylcholinesterase, and α-glycosidase enzymes

et al. 2019

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Many taxa of Salvia genus have been used in herbal beverages, food flavoring, cosmetics, and pharmaceutical industry. In this paper, chemical compounds of Salvia eriophora (S. eriophora) leaves were determined by LC–MS/MS (Liquid Chromatography tandem Mass Spectrometry). Salvigenin (158.64 ± 10.8 mg/kg), fumaric acid (123.09 ± 8.54 mg/kg), and quercetagetin‐3.6‐dimethylether (37.85 ± 7.09 mg/kg) were detected as major compounds in the ethanol extract, whereas fumaric acid (555.96 ± 38.56 mg/kg), caffeic acid (103.62 ± 20.51 mg/kg), and epicatechin (83.19 ± 8.43 mg/kg) were detected as major compounds in the water extract. Furthermore, enzyme inhibition of S. eriophora against acetylcholinesterase (AChE), α‐amylase (AM), butyrylcholinesterase (BChE), and α‐glycosidase (AG) enzymes were detected. AChE, BChE, AG, and AM enzymes were very strongly inhibited by S. eriophora water extract (WES) and S. eriophora methanol extract (MES). Additionally, antioxidant potential of S. eriophora was determined by in vitro analytical methods. IC50 values of WES and MES were performed for radicals. Practical applications Metabolic enzymes have crucial functions on living systems due to inhibition or activation of them mainly attributed with some health disorders. AChE, BChE, AM, and AG enzymes have important roles on carbohydrate metabolism or cholinergic pathways. The relation between enzyme inhibition effect and phenolic compounds or antioxidant activity need to be confirmed. Thus, many studies tested to clarify this relation for pure samples or plant extracts. To the best of our knowledge, this is the first report about inhibition effects of Salvia eriophora extracts against AChE, BChE, AM, and AG enzymes as well as their phenolic contents and antioxidant activities.

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Section: Resultsmentioning

confidence: 99%

Phytochemical content, antioxidant activity, and enzyme inhibition effect ofSalvia eriophoraBoiss. & Kotschy against acetylcholinesterase, α-amylase, butyrylcholinesterase, and α-glycosidase enzymes

et al. 2019

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“…[2] Many recent studies have therefore focused on the therapeutic effects of medicinal plants and their active constituents. [3] In particular, these plants provide sources of a wide variety of natural antioxidants that are employed in the treatment and prevention of diseases in many geographical regions. [4] Natural plant-based antioxidants have been used commercially as either additives or nutritional supplements.…”

Section: Introductionmentioning

confidence: 99%

“…(3) 1. H-NMR (500 MHz, CD 3 OD): 7.63 (d, J = 16.0, HÀ C(7'), 2H), 7.47 (d, J = 9.0, HÀ C(2'/6'), 2H), 6.81 (d, J = 9.0, HÀ C(3'/5'), 2H), 6.33 (d, J = 16.0, HÀ C(8'), 1H), 5.32 -5.37 (m, HÀ C(5), 1H), 4.16 -4.19 (m, HÀ C(3), 1H), 3.73 (dd, J = 10.5, 1.5, HÀ C(4), 1H), 2.04 -2.25 (m, HÀ C(2/6), 4H).…”

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confidence: 99%

Antioxidant and Antimelanogenic Activities of Compounds Isolated from the Aerial Parts of Achillea alpina L.

Lee

Sim

Woo

et al. 2019

Chemistry & Biodiversity

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Achillea alpina is widely distributed in Korea and is often used as a folk medicine for stomach disorders. Although a previous study isolated antioxidant compounds (flavonoid O‐glucoside, sesquiterpene) from this plant, no systematic study of its chemical constituents had been reported. The present study aimed to identify the phytochemicals present in a methanol extract of A. alpina, assess their potential antioxidant activities in vitro, and determine their effects on melanogenesis in B16F10 melanoma cells. Column chromatographic separation of aqueous fractions of A. alpina led to the isolation of 17 compounds. The chemical structures of these compounds were determined using spectroscopic data from electrospray ionization‐mass spectrometry and nuclear magnetic resonance. To the best of our knowledge, the present study is the first to identify compounds 2–10 and 12–17 in A. alpina. Furthermore, compound 6 possessed powerful antioxidant activity, while compound 15 suppressed intracellular tyrosinase activity and thus reduced melanogenesis in B16F10 cells. Therefore, our research suggested that these naturally occurring compounds have the potential to reduce oxidative stress and promote skin whitening. Further investigations will be required to elucidate the mechanisms underlying the antioxidant and antityrosinase activities of these compounds.

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“…These species have been reported to be linked with some cancers, mitochondrial diseases such as Alzheimer's disease (AD), Parkinson's disease, amyotrophic lateral sclerosis, diabetes mellitus, insulin resistance, and cardiovascular disease . By the scavenging of free radicals and ROS, antioxidant substances can protect the human body, decreasing the progression of various chronic diseases …”

Section: Introductionmentioning

confidence: 99%

Phytochemical Content, Antidiabetic, Anticholinergic, and Antioxidant Activities of Endemic Lecokia cretica Extracts

Aras

Bursal

Türkan

et al. 2019

Chemistry & Biodiversity

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The aim of this work was to investigate the enzyme inhibition, antioxidant activity, and phenolic compounds of Lecokia cretica (Lam.) DC. Acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α‐glycosidase enzymes were strongly inhibited by the L. cretica extracts. IC50 values for the three enzymes were found as 3.21 mg/mL, 2.1 mg/mL, and 2.07 mg/mL, respectively. Antioxidant activities were examined in both aqueous and ethanol (EtOH) extracts using CUPRAC, FRAP, and DPPH method. Also, the phenolic compounds of the endemic plant were identified and quantified by using HPLC/MS/MS. According to the results, the extracts have remarkable antioxidant activities. The most abundant phenolic acids of L. cretica in EtOH extract were determined as quinic acid (12.76 mg/kg of crude extract), chlorogenic acid (3.39 mg/kg), and malic acid (2.38 mg/kg).

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Assessment of Antimicrobial and Antioxidant Activities of Nepeta trachonitica: Analysis of Its Phenolic Compounds Using HPLC-MS/MS

Cited by 81 publications

References 59 publications

Phytochemical content, antioxidant activity, and enzyme inhibition effect ofSalvia eriophoraBoiss. & Kotschy against acetylcholinesterase, α-amylase, butyrylcholinesterase, and α-glycosidase enzymes

Phytochemical content, antioxidant activity, and enzyme inhibition effect ofSalvia eriophoraBoiss. & Kotschy against acetylcholinesterase, α-amylase, butyrylcholinesterase, and α-glycosidase enzymes

Antioxidant and Antimelanogenic Activities of Compounds Isolated from the Aerial Parts of Achillea alpina L.

Phytochemical Content, Antidiabetic, Anticholinergic, and Antioxidant Activities of Endemic Lecokia cretica Extracts

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