Assessment of antioxidant, antibacterial, antimycobacterial, and antifungal activities of some plants used as folk remedies in Turkey against dermatophytes and yeast-like fungi

Orhan, Didem Deliorman; Özçelık, Berrın; Hoşbaş, Sanem; Vural, Mecit

doi:10.3906/biy-1203-33

Cited by 28 publications

(4 citation statements)

References 42 publications

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“…Similar results were attained by Sharifa et al, where aqueous, ethanolic or methanolic extracts of P. major did not inhibit the growth of C. albicans and C. tropicalis [77]. Orhan et al by studying antibacterial properties of 21 plants, reported the MIC values of P. major leaf and flower aqueous extracts attained by decoction for 30 min [79]. Decoction was used as the extraction protocol in accordance to folk medicine then, dry matter was attained following freeze-drying of the extract.…”

Section: Plos Onesupporting

confidence: 78%

“…Orhan et al by studying antibacterial properties of 21 plants, reported the MIC values of P . major leaf and flower aqueous extracts attained by decoction for 30 min [ 79 ]. Decoction was used as the extraction protocol in accordance to folk medicine then, dry matter was attained following freeze-drying of the extract.…”

Section: Discussionmentioning

confidence: 99%

“…Decoction was used as the extraction protocol in accordance to folk medicine then, dry matter was attained following freeze-drying of the extract. The inhibition activity was performed by dissolving the dry residue in 30% DMSO and 70% water and MIC values for K. pneumonia, P. aeruginosa, S. aureus, and C. albicans were 128, 64, 32, and 16 μg/mL, respectively [79].…”

Section: Plos Onementioning

confidence: 99%

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Phytochemical evaluation and exploration of some biological activities of aqueous and ethanolic extracts of two species of the genus Plantago L.

Bouali,

Spissu,

Barberis

et al. 2024

PLoS ONE

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Plantago major L. and Plantago lagopus L. are cosmopolitan species, belonging to the Plantaginaceae family, used in traditional and modern medicine. In this study, a phytochemical evaluation of different aqueous and ethanolic extracts of leaves and roots of both species from the region of Beja in Tunisia was performed. Some biological activities, including antioxidant, anticancer and antibacterial were also done. LC-MS qualitative analysis revealed that the aqueous extracts of the roots of P. lagopus were richer in polyphenols, mainly flavonoids (Luteoline 7-rutinoside, Luteoline 7-rhamnoside) and hydroxycinnamic acids including caffeic acid, than the hydro-ethanolic extracts. Additionally, we identified for the first time the presence of salicylic acid in the hot aqueous extracts of roots of P. lagopus and its absence in the roots of P. major. The antioxidant activity of the extracts was assessed using cyclic voltammetry (CV), revealing that the voltammograms of leaf and root extracts from P. lagopus exhibited a higher antioxidant capacity compared to those of P. major. Antiproliferative activity, was determined against two-colon cancer cell lines, demonstrated that only the 12 h treatments with P. lagopus leaf and root aqueous and hydro-ethanolic extracts at low concentration were able to significantly reduce the colon carcinoma coli-2 (CaCo-2) cells proliferation. The antibacterial /antibiofilm activity was performed on yeast, Gram- negative and +positive bacterial strains. We demonstrated for the first time that ethanolic extracts of leaves and roots of P. lagopus have an inhibitory activity against Escherichia coli and Klebsiella pneumonia at MIC = 2 μg/mL for leaves and 4 μg/mL for roots.

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Section: Plos Onesupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

See 1 more Smart Citation

Phytochemical evaluation and exploration of some biological activities of aqueous and ethanolic extracts of two species of the genus Plantago L.

Bouali,

Spissu,

Barberis

et al. 2024

PLoS ONE

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“…A direct antibacterial effect of an aqueous extract of H. helix leaves was assessed for S. pneumonia , S. pyogenes , S. aureus , S. epidermidis , M. tuberculosis , M. avium , H. influenza , and A. baumannii . The MICs ranged from 16 to 64 μg/mL, with the lowest MICs (16 μg/mL) found with M. avium and H. influenzae [ 88 ]. The petroleum and ethanolic extracts were found to be less effective against S. aureus , S. epidermidis , E. coli , K. pneumoniae , P. auruginosa , and P. mirabilis , with MICs of 156.2 μg/mL or higher [ 89 ].…”

Section: Resultsmentioning

confidence: 99%

Mechanistic Evidence of Andrographis paniculata (Burm. f.) Wall. ex Nees, Pelargonium sidoides DC., Echinacea Species and a Combination of Hedera helix L., Primula veris L./Primula elatior L. and Thymus vulgaris L./Thymus zygis L. in the Treatment of Acute, Uncomplicated Respiratory Tract Infections: A Systematic Literature Review and Expert Interviews

Veldman,

Belt-Van Zoen,

Baars

2023

Pharmaceuticals

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Reducing inappropriate antibiotic (AB) use by using effective non-antibiotic treatments is one strategy to prevent and reduce antimicrobial resistance (AMR). Andrographis paniculata (Burm. f.) Wall. ex Nees, Pelargonium sidoides DC., Echinacea species and a combination of ivy (Hedera helix L.), primrose (Primula veris L./Primula elatior L.) and thyme (Thymus vulgaris L./Thymus zygis L.) have promising clinical effects in uncomplicated, acute upper respiratory tract infections (URTI) treatment. However, mechanistic evidence of these herbal treatments is lacking. The objective of this Pstudy is to provide an overview of mechanistic evidence for these effects. Thirty-eight databases were searched. Included studies were mechanistic studies (in vitro, animal, and human studies and reviews) on these herbs; published before June 2021. Non-mechanistic studies or studies on combinations of herbs other than ivy/primrose/thyme were excluded. Furthermore, three experts in traditional, complementary and integrative healthcare (TCIH) research and pharmacognosy were interviewed to collect additional expert knowledge. The results show that A. paniculata acts through immunomodulation and antiviral activity, possibly supplemented by antibacterial and antipyretic effects. P. sidoides acts through antiviral, indirect antibacterial, immunomodulatory and expectorant effects. Echinacea species likely act through immunomodulation. The combination of ivy/primrose/thyme combines secretolytic and spasmolytic effects from ivy with antibacterial effects from thyme. Studies on primrose were lacking. This mechanistic evidence supports the difference-making evidence from clinical studies, contributes to evidence-based recommendations for their use in URTI treatment, and guides future mechanistic studies on URTI treatments.

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Achillea biebersteinii Afan.

Yılmaz

2022

Novel Drug Targets With Traditional Herbal Medicines

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Assessment of antioxidant, antibacterial, antimycobacterial, and antifungal activities of some plants used as folk remedies in Turkey against dermatophytes and yeast-like fungi

Cited by 28 publications

References 42 publications

Phytochemical evaluation and exploration of some biological activities of aqueous and ethanolic extracts of two species of the genus Plantago L.

Phytochemical evaluation and exploration of some biological activities of aqueous and ethanolic extracts of two species of the genus Plantago L.

Achillea biebersteinii Afan.

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