Assessment of antioxidant potential and acute toxicity studies of whole plant extract of pergularia daemia (Forsk)

Vaithiyanathan, Veluchamy; Mirunalini, Sankaran

doi:10.4103/0971-6580.172257

Cited by 11 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antioxidants are widely available in fruits, vegetables, cereal grains, microalgae, and medicinal plants [ 42 , 43 ]. Although antioxidants act to treat or prevent various diseases, when given in overdosage, they can cause toxic effects [ 44 ]. For this reason, we used quercetin at doses of 25, 50, and 100 mg per kg body weight (B.W.)…”

Section: Discussionmentioning

confidence: 99%

Quercetin Attenuates Pancreatic and Renal D-Galactose-Induced Aging-Related Oxidative Alterations in Rats

El‐Far

Lebda

Noreldin

et al. 2020

IJMS

View full text Add to dashboard Cite

Aging is an oxidative stress-associated process that progresses with age. Our aim is to delay or attenuate these oxidative alterations and to keep individuals healthy as they age using natural compounds supplementation. Therefore, we conducted the present study to investigate the protective potentials of quercetin against D-galactose (D-gal)-associated oxidative alterations that were induced experimentally in male Wistar rats. Forty-five rats were randomly allocated into five groups of nine rats each. The groups were a control group that was reared on a basal diet and injected subcutaneously with 120 mg D-gal dissolved in physiological saline solution (0.9% NaCl) per kg body weight daily and quercetin-treated groups that received the same basal diet and subcutaneous daily D-gal injections were supplemented orally with 25, 50, and 100 mg of quercetin per kg body weight for 42 days. Pancreatic and renal samples were subjected to histopathological, immunohistochemical, and relative mRNA expression assessments. Aging (p53, p21, IL-6, and IL-8), apoptotic (Bax, CASP-3, and caspase-3 protein), proliferative (Ki67 protein), antiapoptotic (Bcl2 and Bcl2 protein), inflammatory (NF-κB, IL-1β, and TNF-α), antioxidant (SOD1), and functional markers (GCLC and GCLM genes and insulin, glucagon, and podocin proteins) were determined to evaluate the oxidative alterations induced by D-gal and the protective role of quercetin. D-gal caused oxidative alterations of the pancreas and kidneys observed via upregulations of aging, apoptotic, and inflammatory markers and downregulated the antiapoptotic, proliferative, antioxidant, and functional markers. Quercetin potentially attenuated these aging-related oxidative alterations in a dose-dependent manner. Finally, we can conclude that quercetin supplementation is considered as a promising natural protective compound that could be used to delay the aging process and to maintain human health.

show abstract

Section: Discussionmentioning

confidence: 99%

Quercetin Attenuates Pancreatic and Renal D-Galactose-Induced Aging-Related Oxidative Alterations in Rats

El‐Far

Lebda

Noreldin

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…This particular botanical specimen has been historically employed by individuals in the treatment of jaundice, as an anthelmintic agent, a laxative, an anti-pyretic substance, an expectorant, and has also been utilised in cases of infantile diarrhoea. The plant has undergone phytochemical investigation, revealing the presence of cardenolides, alkaloids, triterpenes, and saponins (Vaithiyanathan and Mirunalini, 2015). As per the findings of Kumar et al (2014), the ethanolic extract of P. daemia demonstrates superior anthelmintic potential in comparison to the aqueous extract.…”

Section: Pergularia Daemiamentioning

confidence: 86%

A Review on Use of Antihelminthic Herbs in Siddha System of Medicine on Children

Priyadarshini,

Subaraj,

Gomathi

et al. 2023

Intern. J. Zool. Invest.

View full text Add to dashboard Cite

Anti-helminthics are a group of anti-parasitic drugs that expel the parasitic worms and other internal parasites from the body by killing them without causing significant damage to the host or the children. The current review focuses on the phytochemical screening in vitro and in vivo studies on herbs such as Akkrottu (Juglans regia), Aamanakku (Ricinus communis), Sathakkuppai (Anethum graveolens), Utthamani (Pergularia daemia), Kuppaimeni (Acalypha indica), Manalikeerai (Gisekia pharnaceoides), Moongil (Bambusa arundinaceae) which were claimed in siddha system for anti-helminthic activity. Thus, herbal medicines play a wide role in removing the parasites of paediatric age group. In siddha system of medicine, there are plenty of herbs mentioned for antihelminthic property. This study shows that how the single herb which is effective for parasites and also the scientific validation of the herbs which contains the medicinally active components for children.

show abstract

“…The extract was further concentrated under vacuum using a rotary vacuum evaporator (Buchi R-V120, Switzerland) at 40°C. The obtained crude extract was weighed and stored at 4 °C for further analysis 7 .…”

Section: Fig 1: Whole Plant Of Cucumis Melo Var Agrestismentioning

confidence: 99%

Untitled

2021

IJPSR

View full text Add to dashboard Cite

Cucumis melo var agrestis (CMA) is belongs to the family of Cucurbitaceae. This plant is also known as wild musk melon it is widely distributed in the coastal areas. Many of the Cucumis species were reported as antioxidants, but there is no report on the antioxidant activity of CMA. The present study is aimed to evaluate the phytochemical analysis and antioxidant activity of different parts (leaves, stem, fruit, seed, flower, and root) extract of Cucumis melo var agrestis. The phytochemical screening confirms the presence of alkaloids, flavonoids, tannins, carbohydrates, saponins, glycosides, proteins, and amino acids in all extracts except Seed extract of CMA (SECMA), Fruit extract of CMA (FRCMA), and Flower extract of CMA (FLCMA) absence with tannins and FLCMA, a Root extract of CMA (RCMA) absence with saponins. Fruit extract of CMA (FRCMA) has the lower IC 50 value for DPPH, ABTS, FRAP, and Phosphomolybdate assay when compared with all other extracts, and also the FRCMA possess higher phenolic and flavonoid content and also its activity is a nearby standard which confirms the higher antioxidant activity of FRCMA. The results of the present study concluded that FRCMA and LCMA has potent antioxidant activity and antioxidant activities are important to healing of many diseases; this research work is important in the future to conduct further studies on fruits of this plant material.

show abstract

Assessment of antioxidant potential and acute toxicity studies of whole plant extract of pergularia daemia (Forsk)

Cited by 11 publications

References 22 publications

Quercetin Attenuates Pancreatic and Renal D-Galactose-Induced Aging-Related Oxidative Alterations in Rats

Quercetin Attenuates Pancreatic and Renal D-Galactose-Induced Aging-Related Oxidative Alterations in Rats

A Review on Use of Antihelminthic Herbs in Siddha System of Medicine on Children

Untitled

Contact Info

Product

Resources

About