2022
DOI: 10.1002/cpz1.569
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Assessment of Antitumor and Antiproliferative Efficacy and Detection of Protein‐Protein Interactions in Cancer Cells from 3D Tumor Spheroids

Abstract: When compared to two-dimensional (2D) cell cultures, 3D spheroids have been considered suitable in vitro models for drug discovery research and other studies of drug activity. Based on different 3D cell culture procedures, we describe procedures we have used to obtain 3D tumor spheroids by both the hangingdrop and ultra-low-attachment plate methods and to analyze the antiproliferative and antitumor efficacy of different chemotherapeutic agents, including a peptidomimetic. We have applied this method to breast … Show more

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