Assessment of Aortic Elasticity in Patients with Celiac Disease

Bayar, Nermin; Çekın, Ayhan Hilmi; Arslan, Şakir; Çağırcı, Göksel; Küçükseymen, Selçuk; Çay, Serkan; Harmandar, Ferda; Yeşil, Bayram

doi:10.4070/kcj.2016.46.2.239

Cited by 11 publications

(14 citation statements)

References 24 publications

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“…In untreated CD, aortic function can deteriorate, and this deterioration is predictive of subclinical atherosclerosis and future cardiovascular events[ 8 ]. Aortic strain and distensibility tend to be significantly lower, and the aortic stiffness index significantly higher, in untreated CD patients vs controls[ 8 , 10 ]. CD patients are at increased risk for coronary artery disease[ 9 ], which may have a genetic association[ 11 ].…”

Section: Publication Summary Statisticsmentioning

confidence: 99%

“…Correlation has been shown between restoration of the small intestinal villous atrophy and normalization of vascular parameters in gluten-abstinent CD patients[ 14 ]. Yet after onset of the GFD, the lack of a significant reduction in aortic elastic properties suggests that some risk of cardiovascular disease may persist[ 10 ]. Type 1 diabetic patients with early presence of micro- or macrovascular complications should always be screened for CD[ 15 ].…”

Section: Publication Summary Statisticsmentioning

confidence: 99%

“…They are also more likely to have greater mean low density lipoprotein (LDL) cholesterol and thicker carotid intima media as compared with controls, and their endothelium-dependent dilatation is decreased, all of which negatively affect vascular function[ 23 , 24 ]. The GFD enables a reduction in inflammatory parameters, oxidative stress, and insulin resistance, factors that when unchecked can lead to atherosclerosis[ 10 , 25 ]. Gluten avoidance followed by restoration of the intestinal villi to normal function is likely to revert cardiovascular dysfunction in less than 1 years’ time[ 2 , 20 , 21 , 23 , 24 ].…”

Section: Publication Summary Statisticsmentioning

confidence: 99%

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Cardiovascular involvement in celiac disease

et al. 2017

WJC

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Celiac disease (CD) is an autoimmune response to ingestion of gluten protein, which is found in wheat, rye, and barley grains, and results in both small intestinal manifestations, including villous atrophy, as well as systemic manifestations. The main treatment for the disease is a gluten-free diet (GFD), which typically results in the restoration of the small intestinal villi, and restoration of other affected organ systems, to their normal functioning. In an increasing number of recently published studies, there has been great interest in the occurrence of alterations in the cardiovascular system in untreated CD. Herein, published studies in which CD and cardiovascular terms appear in the title of the study were reviewed. The publications were categorized into one of several types: (1) articles (including cohort and case-control studies); (2) reviews and meta-analyses; (3) case studies (one to three patient reports); (4) letters; (5) editorials; and (6) abstracts (used when no full-length work had been published). The studies were subdivided as either heart or vascular studies, and were further characterized by the particular condition that was evident in conjunction with CD. Publication information was determined using the Google Scholar search tool. For each publication, its type and year of publication were tabulated. Salient information from each article was then compiled. It was determined that there has been a sharp increase in the number of CD - cardiovascular studies since 2000. Most of the publications are either of the type “article” or “case study”. The largest number of documents published concerned CD in conjunction with cardiomyopathy (33 studies), and there have also been substantial numbers of studies published on CD and thrombosis (27), cardiovascular risk (17), atherosclerosis (13), stroke (12), arterial function (11), and ischemic heart disease (11). Based on the published research, it can be concluded that many types of cardiovascular issues can occur in untreated CD patients, but that most tend to resolve on a GFD, often in conjunction with the healing of small intestinal villous atrophy. However, in some cases the alterations are irreversible, underscoring the need for CD screening and treatment when cardiovascular issues arise of unknown etiology.

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Section: Publication Summary Statisticsmentioning

confidence: 99%

Section: Publication Summary Statisticsmentioning

confidence: 99%

Section: Publication Summary Statisticsmentioning

confidence: 99%

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Cardiovascular involvement in celiac disease

et al. 2017

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“…Many organs or systems such as cardiac, neurological, bone, skin, liver, and endocrin may be involved in the course of CD (13)(14)(15)(16)(17)(18)(19). Although it is an intestinal autoimmune disease, as the diagnostic age of CD getting older, the disease presents itself with complaints that not directed to gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

Fluctuation of liver transaminases with gluten-free diet compliance of a patient with celiac disease and autoimmune hepatitis; a case report

Uyar¹,

Harmandar²,

Gulenay³

et al. 2017

J Turgut Ozal Med Cent

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Although the association of celiac disease with autoimmune hepatitis is well-known, the effect of gluten-free diet on autoimmune hepatitis progression is poorly deafined. We described a patient with celiac disease coexisting with autoimmune hepatitis and effectiveness of gluten-free diet on both diseases. A young patient with eleveted serum liver transaminases was diagnosed as celiac disease and autoimmune hepatitis according to clinical, laboratory and pathological findings. Clinical complaints and laboratory findings of patients resolved exactly after glutenfree diet. However, liver transaminases eleveted and clinical manifestations re-emerged when he left the diet. Clinicians should consider that other autoimmune diseases may occur in the course celiac disease and gluten-free diet may improve also extra-intestinal manifestations of celiac disease.

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“…2 Many studies have been conducted about the aortic elastic changes due to various diseases. [4][5][6][7][8][9][10][11] Bayar et al 4 found changes in arterial stiffness parameters in patients with celiac diseases compared with the healthy when Ülger et al 5 did not find any changes in asthma patients. In this regard, Bektaş et al 6 found a significant change in asthmatic patients compared with posttreatment asthmatic patients.…”

Section: Introductionmentioning

confidence: 97%

Assessment of Aortic Elasticity and the Doppler Tissue Echocardiography in Thalassemia Major Children

Noori

Teimouri

Keshavarz

et al. 2020

Journal of Child Science

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Cardiovascular diseases are the most common illness that needs special medical care in thalassemia particularly in children and adolescents. We aimed to compare aortic stiffness in thalassemia major and healthy children. The study included 65 asymptomatic thalassemia major 6 to 19-year–old children without known history of heart disease and 65 age- and sex-matched healthy controls. Arterial stiffness indices determined using two-dimensional (2D) and Doppler echocardiography. Data were analyzed by SPSS 20.0 with 0.05 as significant error. From the study, results showed that systolic (p = 0.009) and diastolic (p < 0.001) blood pressures were higher in controls. Left ventricular mass index (LVMI) was higher in patients (p < 0.001). Aortic stiffness index (p < 0.001), pulse pressure (p < 0.001), and pressure strain elastic modulus (p < 0.001) were higher in patients, while aortic strain (p < 0.002) and aortic distensibility (p < 0.001) were lower significantly. Aortic stiffness index was correlated with diastole aorta (p = 0.005), systole aorta (p < 0.001), and LVMI (p < 0.001). Strain was correlated with diastole aorta (p < 0.001). Pulse pressure was correlated with systolic blood pressure (p < 0.001), diastolic blood pressure (p = 0.002) significantly. Aortic distensibility was correlated with systolic blood pressure (p = 0.039) and diastole aorta (p < 0.001) significantly. The pressure strain elastic modulus was correlated only with diastole aorta (p = 0.029). Concluded, aortic stiffness index, pulse pressure, and pressure strain elastic modulus were higher in thalassemia children, while aortic strain and aortic distensibility were lower. This increase may result in reduction of mechanical efficiency of the heart. Therefore, assessment of aortic elastic properties as nontraditional cardiovascular risk factors may contribute to the identification of cardiovascular risks in children with thalassemia

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Assessment of Aortic Elasticity in Patients with Celiac Disease

Cited by 11 publications

References 24 publications

Cardiovascular involvement in celiac disease

Cardiovascular involvement in celiac disease

Fluctuation of liver transaminases with gluten-free diet compliance of a patient with celiac disease and autoimmune hepatitis; a case report

Assessment of Aortic Elasticity and the Doppler Tissue Echocardiography in Thalassemia Major Children

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