Assessment of arterial stiffness in patients with venous thromboembolism: Separate or continuous circuits?

Abstract

Objectives The aim of this study is to evaluate the association of venous thromboembolism with arterial stiffness by cardio-ankle vascular index method. Method We included 52 patients with a documented lower extremity venous thromboembolism within the last six months and 52 healthy subjects to this cross sectional observational study. Results Cardio-ankle vascular index (8.58 ± 1.60 versus 7.05 ± 1.44, p < 0.001, respectively) and systolic blood pressure (128.02 ± 7.13 mmHg versus 123.94 ± 8.12 mmHg, p = 0.008, respectively) were significantly higher among patients with venous thromboembolism than controls. Cardio-ankle vascular index was an independent predictor of venous thromboembolism in multivariate logistic regression analysis (p < 0.001, odds ratio = 1.864, 95% confidence interval = 1.370-2.536). Cardio-ankle vascular index value > 7.8 had a sensitivity of 82.7% and a specificity of 80.8% for predicting venous thromboembolism (area under curve = 0.789, 95% confidence interval = 0.698-0.863, p < 0.001) in receiver operating characteristic curve analysis. Conclusion We found that arterial stiffness was increased in patients with venous thromboembolism which highlights the fact that arterial and venous circulation is in continuum and an insult may affect both of these circuits.

Assessment of cardio-ankle vascular index in patients with abdominal aortic aneurysm: An observational study

“…2 CAVI is related to, atherosclerosis, coronary syndrome-x, epicardial fat thickness, dipping status, chronic obstructive lung disease, silent neuronal injury, chronic venous insufficiency and deep vein thrombosis. 17,26–30 Vascular tree is a whole structure and segmental evaluations may cause misinterpretations. Coronary artery disease is prevalent in patients with peripheral artery disease and vice versa.…”

Association between cardio-ankle vascular index and markers of thrombosis in hospitalized patients COVID-19

“…Так, в исследовании A. Aykan и соавт. CAVI значимо выше у пациентов с ВТЭ по сравнению с группой контроля, а также оказался независимым предиктором развития ВТЭ [20], а в исследовании S. Hayashi выявлена достоверная корреляционная связь CAVI с концентрацией D-димера у пожилых пациентов с атеросклеротическим поражением сосудистой стенки [21]. И, наконец, в рамках фрагмента отечественного исследования ЭССЕ-РФ показана связь CAVI и кфСПВ с уровнем D-димера [22].…”