Assessment of Arterial Stiffness Using the Cardio-Ankle Vascular Index – What We Know and What We Strive for

Sumin, А. N.; Щеглова, А. В.

doi:10.20996/1819-6446-2021-08-09

Cited by 5 publications

(8 citation statements)

References 67 publications

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“…В последнем случае можно также вспомнить концепции синдрома раннего сосудистого старения (early vascular aging, EVA) и, наоборот, сверхнормальное старение сосудов (SUPERNOVA -чрезвычайно низкие показатели сосудистой жесткости) [23,24]. Использование индекса START (как и показателя CAVI) мо-жет способствовать поиску защитных механизмов или новых терапевтических целей против процесса старения [25,26]. Если же рассматривать больных АГ, то оценка индекса START может позволить оценивать влияние гипотензивной терапии на динамику развития артериосклероза [27], влияние профилактических программ по борьбе с факторами риска на состояние сосудистой стенки [28], прогнозировать развитие почечной дисфункции [19].…”

Section: артериальная гипертонияunclassified

Comparative analysis of START and CAVI arterial stiffness scores in hypertensive patients

Sumin

Щеглова

Бахолдин

2023

Cardiovasc Ther Prev

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Aim. To compare the novel arterial stiffness index START and the cardio-ankle vascular index (CAVI) in hypertensive (HTN) patients. Material and methods. A total of 709 people with HTN aged 24 to 64 years were examined by volume sphygmography using VaSera VS-1000 (Fukuda Denshi, Japan). CAVI and START values obtained retrospectively from pulse wave velocity and blood pressure were studied using an online calculator.Results. The median CAVI score was within the normal range (<9,0): 7,5 (6,6; 8,4) on the right and 7,4 (6,5; 8,4) on the left. The median of the START index was 6,25 (5,0; 7,55) on the right and 6,4 (5,1; 7,8) on the left. For young people (21-30 years old), the median START score was 4,47, for the CAVI index — 6,25 (p>0,05). In the older age group (61-70 years), the median START index was 7,27, for the CAVI index — 8,4 (p>0,05). The growth pattern of the START score with age was higher by 38,5% than the CAVI index by 25,6% (p=0,034). A high degree of correlation between CAVI and START was noted (r=0,823, p<0,001). Parameters were associated with age (r=0,412 for CAVI and r=0,355 for START; p<0,001), smoking duration (r=0,390 and r=0,361; p<0,001), glomerular filtration rate (r=-0,317 and r= -0,318; p<0,001), body mass index (r=-0,176 and r=-0,185; p=0,001). For the CAVI index, a relationship was found with the glucose level (r=0,192; p<0,001) and a sedentary lifestyle (r=-0,157; p=0,04), while for the START index — with the creatinine level (r=0,143; p=0,01).Conclusion. Patients with hypertension showed a high correlation between the novel START index and the CAVI score (r=0,823, p<0,001). The indicators had similar associations with risk factors, which is important for the subsequent practical application of the START index.

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Section: артериальная гипертонияunclassified

Comparative analysis of START and CAVI arterial stiffness scores in hypertensive patients

Sumin

Щеглова

Бахолдин

2023

Cardiovasc Ther Prev

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“…4 , Соколов В. В. 1,12 Цель. Сравнение сердечно-лодыжечного индекса (CAVI) и нового индекса START, отражающих жесткость сосудистой стенки, оценка их значений и корреляций с клиническими показателями.…”

Section: сравнение нового индекса жесткости сосудистой стенки Start с...unclassified

“…Отношения и деятельность: нет. 1 ООО "Эм Энд Эс Десижанс", Москва, Россия; 2 ФГАОУ ВО Российский университет дружбы народов, Москва, Россия; 3 ФГБОУ ВО Российский экономический университет им. Г. В. Плеханова, Москва, Россия; 4 Первый Московский государственный медицинский университет им.…”

Section: сравнение нового индекса жесткости сосудистой стенки Start с...unclassified

“…В течение последних десятилетий в качестве показателя, позволяющего стратифицировать риск возникновения ССЗ, особый интерес вызывает измерение жесткости сосудистой стенки или артериальной жесткости. Важность этих показателей как прогностических факторов ССЗ и тяжелых сердечно-сосудистых осложнений была оценена и подтверждена во многих исследованиях [1]. Во Фрэмингемском исследовании было показано, что увеличение скорости пульсовой волны (СПВ), маркера артериальной жестко-ступного на отечественном оборудовании.…”

Section: сравнение нового индекса жесткости сосудистой стенки Start с...unclassified

“…Несмотря на очевидные преимущества индекса CAVI над другими показателями артериальной жесткости, его широкое использование в российской клинической практике ограничено фактом доступности приборов для его оценки -в настоящий момент расчет CAVI реализован только в одном коммерческом устройстве -VaSera VS-1500 [1]. Менее очевидными недостатками CAVI являются использование в формуле его расчета эмпирических коэффициентов a и b, полученных хоть и на большой, но преимущественно японской популяции, а также отсутствие учета нелинейных эффектов, влияющих на скорость распространения волны.…”

Section: материал и методыunclassified

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Comparison of the novel START vascular stiffness index with the CAVI index, assessment of their values and correlations with clinical parameters

et al. 2022

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Aim. To compare the cardio-ankle vascular index (CAVI) and the novel START vascular stiffness index and assess their values and correlations with clinical parameters.Material and methods. This multicenter study included 928 (403 men and 525 women) randomly selected patients, aged 18 to 89 years (mean age, 41±15,8 years). Inclusion criteria were age over 18 years. There were following exclusion criteria: mental disorder, severe somatic diseases and cancer, contraindications for volume sphygmography using the Fukuda Denshi VS-1500 VaSera system, no patient consent, ankle-brachial index <1,0 and >1,3. Further, according to the main parameters obtained using volum sphygmography, a novel START index was calculated. Comparison of index values and analysis of their correlation with clinical indicators, such as age, systolic blood pressure, diastolic blood pressure, pulse pressure (PP), body mass index and heart rate (HR), were carried out using simple and multiple linear regression, dispersion analysis, calculation of the Pearson coefficient (r), in the software environment R version 4.0.2.Results. Statistical analysis revealed a high correlation between START and CAVI indices (r=0,986, p<0,001). The values of both indices increase significantly with age (ANOVA p><0,001). Both START and CAVI correlate with all studied clinical parameters. However, in men, there was no relationship of the indices with PP and HR (p>0,05). According to multiple linear regression, the relationship between diastolic blood pressure at the age of 30-60 years and PP at the age of 18-40 years with the START index is more pronounced than with the CAVI index. However, further study of the mathematical model did not reveal a significant difference in the index values for groups with and without high blood pressure.Conclusion. The START vascular stiffness index significantly correlates with the CAVI index, showing no significant differences from CAVI in quantitative relationships with blood pressure, body mass index, heart rate, and sex in various subgroups of the subjects.

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Eotaxin and cardio-ankle vascular index in patients with high and very high cardiovascular risk

et al. 2023

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Eotaxin is a chemokine, which is a chemoattractant mainly to eosinophils, as well as basophils and Th2 lymphocytes. According to studies, overexpression of eotaxin is found in endothelial and smooth muscle cells of blood vessels in the area of atherosclerotic plaque. In clinical medicine, cardio-ankle vascular index (CAVI) is widely used as an indicator of arteriosclerosis and a predictor of cardiovascular events. Few studies have shown the relationship of eotaxin with coronary atherosclerosis; in other studies, the relationship of eotaxin with atherosclerosis, myocardial infarction and pulse wave velocity was not revealed. The aim of the present study was to assess blood level of eotaxin and cardio-ankle vascular index and their association with major cardiovascular risk factors in patients with high and very high cardiovascular risk. We examined 65 patients with high and very high cardiovascular risk, due to documented coronary artery disease, type 2 diabetes mellitus, or combination of cardiovascular risk factors and who were undergoing generally accepted cardioactive, hypoglycemic therapy and lipid-lowering therapy. All patients were examined for the elastic properties of the vascular wall by volumetric sphygmography with assessment of CAVI. In the blood, the concentrations of eotaxin, high-sensitivity C-reactive protein, glycosylated hemoglobin and lipid spectrum indicators were determined. All examined were divided into two groups: with a normal value of CAVI (less than 8) and elevated. Patients with elevated CAVI had higher concentrations of eotaxin (p = 0.013), total cholesterol (p = 0.009), low-density lipoprotein cholesterol (p = 0.016), were older (p < 0.0001) and less likely to take statins (p = 0.002). In all those examined, correlations were found between serum eotaxin concentration and CAVI (rs = 0.34; p = 0.005), as well as age (rs = 0.32; p = 0.006). The age of the patients correlated with CAVI (rs = 0.35; p = 0.007). Thus, in our study, we for the first time showed the relationship between higher concentrations of eotaxin and an increased cardio-ankle vascular index in patients with high and very high cardiovascular risk. Cardio-ankle vascular index was associated with age, lipid metabolism and lipid-lowering therapy. The obtained results allow us to consider eotaxin as a factor associated with atherogenesis and arterial stiffness.

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Assessment of Arterial Stiffness Using the Cardio-Ankle Vascular Index – What We Know and What We Strive for

Cited by 5 publications

References 67 publications

Comparative analysis of START and CAVI arterial stiffness scores in hypertensive patients

Comparative analysis of START and CAVI arterial stiffness scores in hypertensive patients

Comparison of the novel START vascular stiffness index with the CAVI index, assessment of their values and correlations with clinical parameters

Eotaxin and cardio-ankle vascular index in patients with high and very high cardiovascular risk

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