Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non‐invasive laboratory tests

Nguyen‐Khac, Eric; Chatelain, Denis; Tramier, B.; Decrombecque, Catherine; Robert, B.; Joly, Jean Paul; Brevet, Marie; Grignon, P.; Lion, Samir Elias Kalil; Page, L. Le; Dupas, Jean‐Louis

doi:10.1111/j.1365-2036.2008.03831.x

Cited by 200 publications

(160 citation statements)

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“…Castéra et al (9) and Colletta et al (10) have reported that detecting liver fibrosis by Fibroscan resulted in 84-95% of patients not requiring liver biopsy in 2005. Fibroscan has previously been used to evaluate the degree of liver fibrosis in patients with hepatitis B (11), hepatitis C (12,13) cirrhosis (14), alcoholic liver disease (15,16) and autoimmune liver diseases (17). It is also used in antiviral therapy efficacy evaluation (18,19).…”

Section: Introductionmentioning

confidence: 99%

Influencing factors of transient elastography in detecting liver stiffness

Shi

Yin

Yang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Liver stiffness, which correlates well with liver fibrosis stage, can be measured noninvasively by transient elastography, also known as Fibroscan. The present study aimed to determine the independent factors influencing Fibroscan detection by multiple regression analysis. A total of 181 patients who required liver biopsy were enrolled. Liver stiffness measurement (LSM) was detected by Fibroscan on the day of liver biopsy, while clinical information and routine biochemical examination results were also collected. Correlation was analyzed by Spearman's correlation, and multiple regression analysis was performed to analyze the independent influencing factors. The results demonstrated that platelet (PLT) levels, serum albumin (ALB), prothrombin activity (PTA) and body mass index (BMI) were independent predictors of liver stiffness. The contribution of these four predictors to the regression equation was in the following descending order: PLT (negative correlation) > ALB (negative correlation) > PTA (negative correlation) > BMI (positive correlation). In conclusion, the parameters of PLT, ALB, PTA and BMI are independent predicting factors affecting Fibroscan detection. Therefore, the diagnosis and evaluation of liver fibrosis should comprehensively consider the results of Fibroscan, and clinical and laboratory examinations.

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Section: Introductionmentioning

confidence: 99%

Influencing factors of transient elastography in detecting liver stiffness

Shi

Yin

Yang

et al. 2016

Experimental and Therapeutic Medicine

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“…One explanation for this discordance may come from the fact that the reviewed studies were conducted on a population with a heterogenous ethiology of cirrhosis. Pritchatt et al [22] demonstrated that in the HCV group (viral C cirrhosis) the number of false negative cases was significantly higher than in the non-HCV ethiology group (0.6% vs. 10.3%) while Nguyen-Khac et al [27] proved that the cut-off value is higher in alcoholic liver cirrhosis (19,5kPa) compared with the C viral cirrhosis (12,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)6kPa). …”

Section: Disscusionsmentioning

confidence: 99%

Value of hepatic elastography and Doppler indexes for predictions of esophageal varices in liver cirrhosis

Bințințan

Chira

Bințințan³

et al. 2015

Med Ultrason

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Aims: Non-invasive methods are required to diagnose presence and grading of esophageal varices in patients with hepatic cirrhosis and in this respect we have evaluated the role of transient elastography and abdominal ultrasound parameters. Material and methods: Cirrhotic patients were prospectively evaluated by transient elastography and Doppler ultrasound for diagnosis of presence and grading of esophageal varices, the results being compared with the findings of the esophagogastroduodenoscopy. Results: Sixty patients with hepatic cirrhosis were analysed. The parameters that reached statistical significance for diagnosis of esophageal varices were: liver stiffness (LSM) > 15 kPa, hemodynamic liver index (PVr1) ≥ 0.66, portal vascular resistance (PVR) > 17.66 and splenoportal index (SPI) > 4.77. The only parameter that reached statistical power for the diagnosis of large esophageal varices was LSM at a cut-off value of 28.8 kPa. Conclusions: Assessment of LSM in patients with liver cirrhosis can predict both the presence of esophageal varices and of large esophageal varices. The PVr1, PVR and SPI Doppler indexes can be used to diagnose the presence of esophageal varices but have no role in the prediction of large esophageal varices. Further studies are required to confirm these results and offer a stronger clinical significance.

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“…However, this point has been debated by some authors [15]. When there are no signs of severe acute alcoholic hepati-tis and if extensive fibrosis or cirrhosis is suspected, then the Fibrotest® [16]and FibroScan® [17] give satisfactory diagnostic performances.…”

Section: Alcoholic Liver Diseasementioning

confidence: 99%