Assessment of Biometal Profile in Children with Autism Spectrum Disorder, with Attention Deficit Hyperactivity Disorder, or with Other Psychiatric Diagnoses: A Comparative Outpatient Study

Abstract

Background: In recent years, the impact of various micronutrients on the symptoms of ADHD and ASD has been studied. Our study was aimed at evaluating the association between the level of serum magnesium, zinc and ferritin in children diagnosed with ADHD and/or ASD. Methods:This case-control pilot study consisted of 32 children who met DSM-V criteria for ADHD, 15 children who met DSM-V criteria for ASD and 12 age-matched control children from Electronic Medical Record database. Serum magnesium, zinc and ferritin values were com-pared with ANOVA.Results: Blood ferritin level was found to be significantly lower in affected groups (F=5.9, p=0.0056). A trend towards decreased values of plasma zinc level was also found in affected children (F=2.25, p=0.12); whereas no suggestion of any difference in blood magnesium levels between three groups was significant. Non-parametric analyses were also run and the p value for ferritin 0.08, showed weaker evidence of significance. Conclusions:Results of this study indicated that low level of blood ferritin may be a risk factor for development of ASD and ADHD. Future investigations with larger controlled trials are needed and correlational studies would also be helpful.

Plasma zinc, copper and serum ceruloplasmin levels of autism spectrum disorder children in Bangladesh

“…However, despite the fact that the mean Zn level in children with ASD was lower than in healthy children, this study did not identify any statistically significant differences in the mean Zn levels between the study group and the control group in any of the age groups ranging from 2 to 5 years or from 6 to 9 years. Studies conducted in a variety of states in the United States of America also observed comparable results in plasma, serum, or hair samples taken from children with ASD spanning a range of ages, from early infancy to adulthood [ 8 , 10 , 27 , 28 ].…”