Assessment of Blood Microcirculation Changes after COVID-19 Using Wearable Laser Doppler Flowmetry

Zharkikh, Elena V.; Loktionova, Yulia I.; Fedorovich, A.A.; Gorshkov, A. Yu.; Dunaev, Andrey V.

doi:10.3390/diagnostics13050920

Cited by 11 publications

(7 citation statements)

References 40 publications

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“…It is also worth noting that the authors [43] could demonstrate the use of peripheral blood flow oscillations analysis with wearable LDF devices to diagnose vascular disorders in patients who have undergone COVID-19 in their early and advanced stages of recovery. Obtained results show a significant increase in the amplitude of neurogenic oscillations in the upper extremities of patients undergoing COVID-19, which may be a factor preceding dilation of arterioles and venules and redirection of microcirculatory blood flow from the nutritive to the shunt pathways.…”

Section: One Of the First Examples Of The Application Of Multimodalmentioning

confidence: 99%

Wearable Devices for Multimodal Optical Diagnostics of Microcirculatory-Tissue Systems: Application Experience in the Clinic and Space

Dunaev

2023

J-BPE

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This work demonstrates some results of the successful experience of using wearable devices for multimodal optical diagnostics of microcirculatorytissue systems both in clinical practice and in the conditions of a Space experiment. The multimodal approach based on simultaneously applying a minimum of 2 optical diagnostic methods, for example, laser Doppler flowmetry and fluorescence spectroscopy, allows analysing of blood flow and metabolic processes in biological tissue more systematically. Combining several wearable devices into a distributed diagnostic system allows placing them simultaneously on symmetrical parts of the body (such as opposite limbs) thus providing a possibility to study the symmetry of the measured signals. The obtained data on the state of the microcirculatory-tissue systems of the human body recorded with wearable multimodal devices make it possible to assess the relationship and dynamics of oxygen delivery and utilization by tissues more comprehensively and reliably in a variety of diagnostic tasks.

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Section: One Of the First Examples Of The Application Of Multimodalmentioning

confidence: 99%

Wearable Devices for Multimodal Optical Diagnostics of Microcirculatory-Tissue Systems: Application Experience in the Clinic and Space

Dunaev

2023

J-BPE

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“…The development of thrombosis and impaired functioning of the microvasculature are common complications of COVID-19 [215]. Past infection with COVID-19 (10 days after illness) increased the amplitudes of neurogenic, respiratory, and cardiac rhythms [4]. For rheumatoid disorders, an increase in the amplitude of the cardio-and respiratory rhythm is also a characteristic [180].…”

Section: Rhythms Of Skin Blood Perfusion Oscillationsmentioning

confidence: 99%

“…The practical value lies in the search for a connection between the development of pathologies and violations of rhythmic processes. Examples are the association of the development of epilepsy and other disorders of the brain with changes in the patterns of EEG rhythms and the possibility of using the characteristics of oscillations in the speed of skin microcirculation and heart rate variability in the diagnosis of systemic disorders in humans [3][4][5]. Methods for correcting stress-induced disorders in humans are also being developed by changing the body's own rhythms using feedback schemes [6].…”

Section: Introductionmentioning

confidence: 99%

Application of Spectral Methods of Analysis for Description of Ultradian Biorhythms at the Levels of Physiological Systems, Cells and Molecules (Review)

2023

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The presence of biological rhythms is a characteristic of all living organisms. Over the past 60 years, scientists around the world have accumulated a huge amount of data on rhythmic processes in living systems at various levels. The acquired knowledge has found applications in human economic activity and medicine. The ultradian (less than a day) rhythms at the organismal, organ, and cellular levels are characterized by high diversity. Unfortunately, biorhythms in different systems are considered, most often, in isolation from each other. Much knowledge about biorhythms was obtained using expert evaluation methods, and later methods of spectral analysis were used to describe biorhythms. Ultradian rhythms have a relatively short duration; therefore, they can be characterized by spectral analysis methods. More and more researchers believe that in order to further expand the understanding of the nature and purpose of biorhythms, the use of more advanced methods of mathematical processing is required, and rhythms in different organs, tissues, and cells should be considered parts of a single system. This review is intended to provide the reader with the variety of ultradian rhythms in living systems (organismal, organ, cellular, molecular levels), the mechanisms of their generation, and their functions to give the reader a picture of the possible relationships between these rhythms. Further, the reader will be able to get acquainted with the variety of mathematical methods for analyzing biorhythms, including bispectral and cross-correlation analyses.

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“…Alterations in microcirculation are associated with various pathologies, such as cancer [1], diabetes [2,3], hypertension [4], sepsis [5], and viral infections [6]. This field is still very much alive, as witnessed by the new publications on the influence of microcirculation in various pathologies [7], including Covid [8], and the renewed interest in the associated dynamic speckle technology [9][10][11]. Therefore, monitoring the peripheral microcirculation of the body holds significant diagnostic potential.…”

Section: Introductionmentioning

confidence: 99%

Standardizing Laser Speckle Orthogonal Contrast Imaging: Achieving Reproducible Measurements across Instruments

Orlik,

Colin,

Plyer

2024

Photonics

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Using two independent speckle imaging systems based on the recently published LSOCI method operating in contact mode on the skin, we assess the reproducibility of in vivo measurements and conduct an inter-instrument comparison. To this aim, we propose a calibration method to handle each imaging system as a comprehensive unit, which includes the laser source, optics, and camera. Key to our method is the introduction of a new index that quantifies the departure of the temporal contrast observed in vivo from the spatial contrast scattered from a reference static element generating a circular Gaussian speckle field. Using such near-real-time calibration method, we demonstrate that the microcirculation images produced by 2 different instruments exhibit high accuracy and stability, with microcirculation activity values in excellent agreement, thereby paving the way for clinical applications.

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Assessment of Blood Microcirculation Changes after COVID-19 Using Wearable Laser Doppler Flowmetry

Cited by 11 publications

References 40 publications

Wearable Devices for Multimodal Optical Diagnostics of Microcirculatory-Tissue Systems: Application Experience in the Clinic and Space

Wearable Devices for Multimodal Optical Diagnostics of Microcirculatory-Tissue Systems: Application Experience in the Clinic and Space

Application of Spectral Methods of Analysis for Description of Ultradian Biorhythms at the Levels of Physiological Systems, Cells and Molecules (Review)

Standardizing Laser Speckle Orthogonal Contrast Imaging: Achieving Reproducible Measurements across Instruments

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