Assessment of bone dose response using ATR-FTIR spectroscopy: A potential method for biodosimetry

Bones offer a great amount of information on ancient populations regarding both their lifestyle habits and the influence of the living area. Bones are composed by an inorganic component, i.e., carbonated hydroxyapatite (Ca10[(PO4)6−x(CO3)x](OH)2), and an organic matrix (mainly proteins and collagen). After death, bones are subjected to diagenetic processes, with changes in structure, morphology, and chemical composition. All these modifications strictly depend on several factors, including the nearby environment, the climate, and the burial modality. Hence, a precise knowledge of the diagenetic processes affecting bones after death is mandatory. In this study, archeological human bones from the Garamantian necropolis of Fewet (Libyan Sahara) were analyzed by ATR–FTIR spectroscopy to elucidate the role of the burial location and modality, as well as the highly arid environment in the diagenesis rate. Several spectral parameters related to structural and chemical features of the organic and mineral components (i.e., AmideI/PO4, C/P, MM, FWHM603, and IRSF indexes) were statistically analyzed. Spectral data were compared with those from modern ruminants from the same site to evaluate a possible time-dependent correlation between the chemical composition and the diagenetic processes. A mild diagenesis was found in all human bones, even though it had a variable degree depending on the burial location.

show abstract

Evidence for Mild Diagenesis in Archaeological Human Bones from the Fewet Necropolis (SW Libya): New Insights and Implications from ATR–FTIR Spectroscopy

Castorina

Masi

Giorgini

et al. 2023

Applied Sciences

View full text Add to dashboard Cite

show abstract

Radiobiological Applications of Vibrational Spectroscopy: A Review of Analyses of Ionising Radiation Effects in Biology and Medicine

Monaghan,

Byrne,

Lyng

et al. 2024

Radiation

View full text Add to dashboard Cite

Vibrational spectroscopic techniques, such as Fourier transform infrared (FTIR) absorption and Raman spectroscopy (RS), offer unique and detailed biochemical fingerprints by detecting specific molecular vibrations within samples. These techniques provide profound insights into the molecular alterations induced by ionising radiation, which are both complex and multifaceted. This paper reviews the application of rapid and label-free vibrational spectroscopic methods for assessing biological radiation responses. These assessments span from early compartmentalised models such as DNA, lipid membranes, and vesicles to comprehensive evaluations in various living biological models, including tissues, cells, and organisms of diverse origins. The review also discusses future perspectives, highlighting how the field is overcoming methodological limitations. RS and FTIR have demonstrated significant potential in detecting radiation-induced biomolecular alternations, which may facilitate the identification of radiation exposure spectral biomarkers/profiles.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Assessment of bone dose response using ATR-FTIR spectroscopy: A potential method for biodosimetry

Cited by 2 publications

References 45 publications

Evidence for Mild Diagenesis in Archaeological Human Bones from the Fewet Necropolis (SW Libya): New Insights and Implications from ATR–FTIR Spectroscopy

Evidence for Mild Diagenesis in Archaeological Human Bones from the Fewet Necropolis (SW Libya): New Insights and Implications from ATR–FTIR Spectroscopy

Radiobiological Applications of Vibrational Spectroscopy: A Review of Analyses of Ionising Radiation Effects in Biology and Medicine

Contact Info

Product

Resources

About