Assessment of bone marrow histology in the malignant lymphomas (non‐Hodgkin's): correlation with clinical factors for diagnosis, prognosis, classification and staging

Bartl, Reiner; Frisch, Bertha; Burkhardt, R.; Kettner, G.; Mahl, G.; Fateh-Moghadam, A.; Sund, M.

doi:10.1111/j.1365-2141.1982.tb02815.x

Cited by 43 publications

(20 citation statements)

References 36 publications

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“…Our findings of 25% of peripheral blood involvement in CSI and II NHL may indicate the source of failure in a proportion of these patients. If peripheral blood lymphoma cells represent bone marrow disease we may also speculate that in low grade lymphoma their detection will be of no prognostic significance (Bartl et al, 1982;Lindemalm et al, 1985;Bennett et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

Circulating lymphoma cells in patients with B & T non-Hodgkin's lymphoma detected by immunoglobulin and T-cell receptor gene rearrangement

Brada

Mizutani²,

Molgaard³

et al. 1987

Br J Cancer

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We studied peripheral blood mononuclear cells from 50 patients with active B- and T-cell non-Hodgkin's lymphoma by DNA hybridisation. Nineteen patients (38%) had circulating clones of cells detected by immunoglobulin gene rearrangement (17 patients) or T-cell receptor gene rearrangement (2 patients) with JH and J beta 2 probes. Lymphoma tissue and peripheral blood were studied simultaneously in 22 patients, 9 of which had a circulating clone of cells in peripheral blood. In 7 patients the gene rearrangement in lymphoma tissue and peripheral blood mononuclear cells was identical. However, in 2 patients both heavy chain and light chain gene rearrangements were different in tissue and peripheral blood. The incidence of peripheral blood involvement was commonest in advanced CSIII & IV disease (54%) compared to CSI & II disease (18%) (P less than 0.05), and in low grade (45%) compared to intermediate and high grade lymphoma (31%) (difference not statistically significant). Only 4 patients had definite lymphoma cells seen on peripheral blood smear. The presence of circulating lymphoma cells correlated with conventional assessment of bone marrow involvement although circulating clones were detected in 30% (12/40) of patients with apparently normal bone marrow. Images Figure 1 Figure 2 Figure 3

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Section: Discussionmentioning

confidence: 99%

Circulating lymphoma cells in patients with B & T non-Hodgkin's lymphoma detected by immunoglobulin and T-cell receptor gene rearrangement

Brada

Mizutani²,

Molgaard³

et al. 1987

Br J Cancer

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“…Histologically, patients with CLL show either nodular, interstitial, or diffuse marrow infiltration, with the diffuse pattern carrying the poorest prognosis [11,76,83]. Whether the different infiltration patterns are attributable solely to variable adhesive properties of the CLL The adherent layer of long-term cultures from CLL marrow is morphologically indistinguishable from that of normal cultures [131].…”

Section: Stromal Abnormalities In Cllmentioning

confidence: 99%

Stromal abnormalities in neoplastic bone marrow diseases

Dührsen

Hossfeld

1996

Annals of Hematology

100

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Bone marrow malignancies are clonal disorders resulting from neoplastic transformation of hematopoietic stem or progenitor cells. Similar to their normal counterparts, transformed blood-forming cells remain dependent on signals from the hematopoiesis-regulating stromal environment for survival and proliferation. There is increasing evidence that the microenvironment may also take a more active part in the disease process. A review of the literature on stromal abnormalities in the leukemias, the myelodysplastic syndromes, and multiple myeloma reveals three principal mechanisms by which stromal derangements can contribute to the evolution of a neoplastic disease. In the simplest case, neoplastic blood-forming cells induce reversible changes in stroma function or composition which result in improved growth conditions for the malignant cells ('malignancy-induced microenvironment'). In the second setting, functionally abnormal end cells derived from the malignant clone become an integral part of the stroma system, selectively stimulating the neoplastic cells and inhibiting normal blood cell formation ('malignant microenvironment'). In the third condition, the emergence of a neoplastic cell population is the consequence of a primary stroma lesion characterized by inability to control regular blood cell formation ('malignancy-inducing microenvironment'). The perception of different stroma-related disease mechanisms may eventually lead to the development of alternative therapeutic approaches.

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“…However, since at the time these studies were performed diagnostic haematopathology was dominated by the Kiel classification in Europe and the Working Formulation in the States, the investigators subtyped NHL according to these systems and used the corresponding terminology [3,17,19,28,41].…”

Section: Introductionmentioning

confidence: 99%

Guidelines for subtyping small B-cell lymphomas in bone marrow biopsies

et al. 1999

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In this review, we summarise the patterns of bone marrow involvement by small B-cell lymphomas. Both our own experience and the literature reports on the subject show that each subtype of lymphoma can be recognised from a distinct combination of a suggestive growth pattern and a particular cytological composition. A predominantly paratrabecular infiltrate composed of centrocytes is characteristic of follicle centre cell lymphoma. In mantle cell lymphoma, prominent intertrabecular nodules, each consisting of a monotonous proliferation of small to intermediate-sized lymphoid cells with an irregular nucleus, are the most frequent finding. Marginal zone cell lymphoma displays similar intertrabecular nodules, but the infiltrates are rather loose and polymorphic, whereas the lymphoid cells exhibit monocytoid features. Diffuse infiltrates composed of small lymphocytes with clumped chromatin, of plasma cells with Dutcher bodies and of mast cells are observed in most cases of lymphoplasmacytoid lymphoma/immunocytoma. Although chronic lymphocytic leukaemia / small lymphocytic lymphoma can present with a comparable pattern of bone marrow involvement, an interstitial infiltrate of small lymphoid cells is usually observed. A comparable interstitial pattern also prevails in hairy cell leukaemia. This lymphoma subtype, however, can be readily identified by the abundant clear cytoplasm of the neoplastic cells, erythrocyte extravasation and associated abnormalities in the haematopoietic series.

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Assessment of bone marrow histology in the malignant lymphomas (non‐Hodgkin's): correlation with clinical factors for diagnosis, prognosis, classification and staging

Cited by 43 publications

References 36 publications

Circulating lymphoma cells in patients with B & T non-Hodgkin's lymphoma detected by immunoglobulin and T-cell receptor gene rearrangement

Circulating lymphoma cells in patients with B & T non-Hodgkin's lymphoma detected by immunoglobulin and T-cell receptor gene rearrangement

Stromal abnormalities in neoplastic bone marrow diseases

Guidelines for subtyping small B-cell lymphomas in bone marrow biopsies

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