Assessment of bone turnover markers to predict mineral and bone disorder in men with pre-dialysis non-diabetic chronic kidney disease

Davina, Joseph Jessy; Priyadarssini, M.; Rajappa, Medha; Parameswaran, Sreejith; Sahoo, Jayaprakash; Raj, Pallavi; Revathy, G.; Chinnakali, Palanivel; Marella, Marie Gilbert

doi:10.1016/j.cca.2017.04.010

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…A recent study from the United States reported the prevalence of MS to be around 22.9% [7]. Various population-based studies were conducted in India too, to quantify the same and the results ranged from 10 to 30 percentage [8]. A study conducted in the eleven large urban cities of India during 2006-2010 reported the prevalence of MS as high as 35% [9].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of metabolic syndrome among adult population in India: A systematic review and meta-analysis

et al. 2020

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This review was done to determine the prevalence of metabolic syndrome (MS) among adult general population in India. We also wanted to find the gender, setting, and regionwide distribution of MS in India. Methods We conducted systematic searches in various databases including Medline, ScienceDirect, Cochrane library and Google Scholar from inception until August 2019. We included studies conducted in India reporting the prevalence of MS among adults aged 18 years or more. We used the Newcastle Ottawa scale to assess the quality of included studies. We carried out a meta-analysis with random-effects model and reported pooled prevalence with 95% confidence intervals (CIs). We used the Funnel plot to assess publication biases. Results In total, we analysed 113 data from 111 studies with 133,926 participants. Majority of the included studies (76 out of 111) had low risk of bias. We found significant heterogeneity among the included studies (p<0.001). We also found a symmetrical funnel plot indicating an absence of publication bias. The prevalence of MS among adult population in India was 30% (95%CI: 28%-33%). There was a steady increase in the burden across the age groups from 13% (18-29 years group) to 50% (50-59 years). We also found that people living in urban areas (32%; 95%CI: 29%-36%) had higher prevalence when compared to tribal (28%; 95%CI: 21%-36%) or rural adults (22%; 95%CI: 20%-25%). Gender distribution of MS showed that the females had higher prevalence (35%; 95%CI: 31%-38%) when compared to males 26% (95%CI: 22%-29%). Conclusion Almost one in three adults in India suffer from MS. Females, people living in urban areas and in northeast region had higher prevalence of MS. Development and implementation of

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Section: Introductionmentioning

confidence: 99%

Prevalence of metabolic syndrome among adult population in India: A systematic review and meta-analysis

et al. 2020

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“…A recent study from the United States reported the prevalence of MS to be around 22.9%. 13 Various populationbased studies were conducted in India too, to quantify the same and the results ranged from 10 to 35% 14,15 Central obesity is more atherogenic as compared to peripheral obesity. 16 In the above context this present study was undertaken to determine the prevalence of metabolic syndrome in acute coronary syndrome.…”

Section: Discussionmentioning

confidence: 99%

Prevalence Of Metabolic Syndrome In Acute Coronary Syndrome

Upadhaya,

Godi,

Kaneria

et al. 2023

SFS

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Globally, metabolic syndrome presents as one of the leading health problems associated with increased morbidity and mortality from cardiovascular disease. Studies suggest that little is known about the prevalence of metabolic syndrome in patients with acute coronary syndrome in Indian subcontinent. Hence, our study aimed to ascertain the prevalence of metabolic syndrome and its clinical and angiographic profile in patients with acute coronary syndrome in Northwest Indian population.An observational study was conducted in the cardiology department of Pacific Medical College & Hospital, Rajasthan among 100 patients diagnosed with acute coronary syndrome for duration of one and half year. Demographic, clinical data, serum lipid profile, serum glucose was measured. Analysis was done using SPSS-23. The data were expressed as rates, ratios, proportions and mean ± standard deviation. The comparison of data was performed using Chi-square test/ Fisher's exact test, independent sample t-test. p<0.05 was considered statistically significant.The prevalence of metabolic syndrome in acute coronary syndrome was found to be 65%. Among the components of metabolic syndrome, waist circumference >90 cm for males, fasting blood sugar, previously diagnosed cases of diabetes mellitus, hypertriglyceridemia, low HDL cholesterol were significantly higher in MS group. Raised fasting Blood Sugar and systemic hypertension resulted in higher mortality.In the present study, metabolic syndrome was highly prevalent in acute coronary syndrome patients, with male predominance. Anthropometric measurements like waist circumference, waist-hip ratio, and BMI, which are easy clinical tools to identify obesity, should be routinely used in clinical practice.

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“…A strong correlation has also been observed between serum ALP, iPTH and BMD [112,138], suggesting serum ALP may serve as a useful substitute for PTH as a biochemical marker to identify patterns of bone turnover [112]. An additional study suggested that the combined monitoring of BSAP and iPTH provides significant predicting power for non-invasive assessment of bone health in CKD and is a more reliable index than either marker used alone [139]. However, the beneficial predicting power of combining PTH and BSAP markers has not been completely verified yet.…”

Section: Alkaline Phosphatasementioning

confidence: 99%

Current and Emerging Markers and Tools Used in the Diagnosis and Management of Chronic Kidney Disease–Mineral and Bone Disorder in Non-Dialysis Adult Patients

Fusaro,

Pereira,

Bover

2023

JCM

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Chronic kidney disease (CKD) is a significant public health concern associated with significant morbidity and has become one of the foremost global causes of death in recent years. A frequent comorbidity of CKD is secondary hyperparathyroidism (SHPT), exemplified by high serum parathyroid hormone (PTH) levels. The mineral metabolism disturbances resulting from CKD and progression to SHPT are currently considered part of the definition of chronic kidney disease–mineral and bone disorder (CKD-MBD). However, CKD-MBD does not only include abnormalities in laboratory-measured parameters; it is a complex condition characterized by dysregulation of bone turnover, mineralization, growth and strength, accompanied by vascular or another soft-tissue calcification. Together, this increases the risk of bone fractures, cardiovascular disease, and overall mortality in CKD-MBD patients. Monitoring serum markers is essential in diagnosing SHPT and CKD-MBD, and there are several recognized indicators for prognosis, optimal clinical management and treatment response in late-stage kidney disease patients receiving dialysis. However, far fewer markers have been established for patients with non-dialysis CKD. This review provides an overview of current and emerging markers and tools used in the diagnosis and management of CKD-MBD in non-dialysis adult patients.

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Assessment of bone turnover markers to predict mineral and bone disorder in men with pre-dialysis non-diabetic chronic kidney disease

Cited by 5 publications

References 20 publications

Prevalence of metabolic syndrome among adult population in India: A systematic review and meta-analysis

Prevalence of metabolic syndrome among adult population in India: A systematic review and meta-analysis

Prevalence Of Metabolic Syndrome In Acute Coronary Syndrome

Current and Emerging Markers and Tools Used in the Diagnosis and Management of Chronic Kidney Disease–Mineral and Bone Disorder in Non-Dialysis Adult Patients

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