Assessment of caffeine neurotoxicity using novel biomarkers of neural function in SH-SY5Y cells – Is there a need for environmental concern?

Aquatic ecological problems caused by pharmaceutical and personal care products (PPCPs) are increasingly becoming an issue of concern. In this study, the seasonal and spatial occurrence and environmental risk of 20 PPCPs were studied at 19 sampling points in the surface waters of the Lianjiang River basin (southern of China); its watershed is about 10,100 km2. Sample preparation was performed using solid-phase extraction, and determination was performed by using a high-performance liquid-phase tandem triple quaternary mass spectrometer. Nine PPCPs were detected with total concentrations of 19.5–940.53 and 6.07–186.04 ng L−1 during the wet (August 2021) and dry (April 2022) seasons, respectively. Four kinds of compounds—sulfamethoxazole (SMX), sulfamonomethoxine (SMM), caffeine (CAF), and florfenicol (FFC)—had a detection rate of more than 50% in both seasons. CAF, carbamazepine (CBZ), and FFC were higher in the wet season than in the dry season in the Lianjiang River possibly due to the higher usage of PPCPs and increased tourism during summer. SMX and SMM showed higher average concentrations in the dry season possibly due to lower biodegradation in the dry season and a slight dilution effect from rainfall. The concentrations of SMX, SMZ, SMM, and FFC were strongly correlated with NO3−, according to redundancy analysis and Spearman’s correlation analysis. The results of the risk quotient revealed that the ecological effect of CAF concentrations on green algae had low risk at all sampling points except R16.

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Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans: an overview of recent findings

Serra,

Simola,

Pollack

et al. 2023

Neural Regeneration Research

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Preclinical and clinical studies indicate that psychostimulants, in addition to having abuse potential, may elicit brain dysfunctions and/or neurotoxic effects. Central toxicity induced by psychostimulants may pose serious health risks since the recreational use of these substances is on the rise among young people and adults. The present review provides an overview of recent research, conducted between 2018 and 2023, focusing on brain dysfunctions and neurotoxic effects elicited in experimental models and humans by amphetamine, cocaine, methamphetamine, 3,4-methylenedioxymethamphetamine, methylphenidate, caffeine, and nicotine. Detailed elucidation of factors and mechanisms that underlie psychostimulant-induced brain dysfunction and neurotoxicity is crucial for understanding the acute and enduring noxious brain effects that may occur in individuals who use psychostimulants for recreational and/or therapeutic purposes.

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Assessment of caffeine neurotoxicity using novel biomarkers of neural function in SH-SY5Y cells – Is there a need for environmental concern?

Cited by 3 publications

References 51 publications

Undifferentiated versus retinoic acid-differentiated SH-SY5Y cells in investigation of markers of neural function in toxicological research

Undifferentiated versus retinoic acid-differentiated SH-SY5Y cells in investigation of markers of neural function in toxicological research

Occurrences, Seasonal Variations, and Potential Risks of Pharmaceutical and Personal Care Products in Lianjiang River, South of China

Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans: an overview of recent findings

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