The homogeneity of the schemes for follow-up
care after curative surgical treatment of early breast cancer is
still a matter of debate in Germany. We investigated whether
symptom-oriented follow-up is equivalent in terms of survival
rates to conventional surveillance based on scheduled tests.
Patients and Methods: In a prospective, non-randomised,
multicentre cohort study carried out between 1995 and 2000,
244 patients underwent a conventional follow-up (scheduled
laboratory tests including CEA and CA 15-3, chest X-rays and
liver ultrasound). 426 patients were monitored in a symptomoriented
manner (additional tests only in the case of symptoms
indicating possible recurrence). Mammography, structured
histories and physical examinations were done regularly
in both branches. 1,108 patients did not participate in the project.
They represent ‘real world patients’, unaffected by the
implications of a study. Results: The symptom-oriented follow-
up group produced results not inferior to those of the intensive
one (p < 0.05) in terms of overall and relapse-free survival.
Furthermore, no difference was indicated in terms of
overall survival between study participants and the ‘real world
patients’ (p = 0.316). Conclusion: The results confirm that regular
imaging and laboratory tests have no relevant effect on
overall survival of patients after curative primary therapy of
early breast cancer and support the implementation of a
symptom-oriented routine follow-up.