Assessment of Cardiovascular Risk Factors after Renal Transplantation: A Step towards Reducing Graft Failure

Kumar, Rakesh; Brar, J.; Yacoub, Rabi; Khan, Tasnim; Zachariah, Mareena; Venuto, Rocco C.

doi:10.1016/j.transproceed.2012.01.111

Cited by 6 publications

(5 citation statements)

References 54 publications

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“…After transplantation many renal transplant recipients (RTR) are at high cardiovascular disease risk, of which, new onset of diabetes after transplantation, hypertension, and being overweight play an important role [ 1 – 3 ]. Accordingly, the incidence of cardiovascular disease (CVD) in RTR is four to six times higher than in the general population [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Fear of Movement and Low Self-Efficacy Are Important Barriers in Physical Activity after Renal Transplantation

et al. 2016

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BackgroundPhysical activity (PA) and exercise are commonly used as preventive measures for cardiovascular disease in the general population, and could be effective in the management of post-transplantation cardiovascular risk. PA levels are low after renal transplantation and very few renal transplant recipients (RTR) meet the PA guidelines. Identification of barriers to regular PA is important to identify targets for intervention to improve PA levels after renal transplantation. We investigated fear of movement and physical self-efficacy as barriers to PA in RTR.MethodsRTR were investigated between 2001–2003. The Tampa Score of Kinesiophobia–Dutch Version (TSK-11) was used to assess fear of movement. Physical self-efficacy was measured with the LIVAS-scale. PA was assessed using validated questionnaires (Tecumseh Occupational Activity Questionnaire and the Minnesota Leisure Time Physical Activity Questionnaire).ResultsA total of 487 RTR (age 51±12 years, 55% men) were studied. Median score [interquartile range] on TSK-11 was 22 [17–26]. Low physical self-efficacy (Exp B:0.41[0.31–0.54], p<0.001) and history of myocardial infarction, transient ischemic attack and cerebrovascular accident (Exp B:1.30[1.03–1.63],p = 0.03) were independent determinants for fear of movement. Fear of movement was associated with lower daily PA, occupational, sports and leisure time PA. Mediation-analysis showed that a large part (73%) of the effect of fear of movement on PA was explained by low physical self-efficacy.ConclusionsThis study was the first to examine fear of movement and self-efficacy in relation to PA in RTR. Fear of movement was associated with a low PA level, and the larger part of this relation was mediated by low physical self-efficacy. Both fear of movement and physical self-efficacy level are important targets for intervention during rehabilitation after renal transplantation.

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Section: Introductionmentioning

confidence: 99%

Fear of Movement and Low Self-Efficacy Are Important Barriers in Physical Activity after Renal Transplantation

et al. 2016

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“…The problem is that the results of Hosseini et al are not fully comparable to other reports, as different definitions of dyslipidemia were used in particular papers, e.g. Hosseini et al considered low-density lipoprotein (LDL) level as high at 130 mg/dL, while others reported LDL level exceeding 100 mg/dL as too high (1, 2). Additionally, many key factors were omitted in the analysis of Hosseini et al, e.g.…”

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confidence: 94%

“…Dyslipidemia is a risk factor for cardiovascular disease in the general population, and is common after renal transplantation. Despite the fact that the relationship between dyslipidemia and cardiovascular mortality has not been proven in transplant recipients, dyslipidemia is considered as a condition that should be aggressively treated in this population (1, 2). Hosseini et al (3), searching for the correlation between dyslipidemia and both trough level (C0) and two hour post dose level (C2) of Cyclosporine A (CsA), retrospectively analysed a relatively large group of kidney transplant recipients.…”

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confidence: 99%

Dyslipidemia in Renal Transplant Recipients Treated With Cyclosporine A

Niemczyk

2013

Nephro Urol Mon

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“…1,2 The function and survival of allografts are significantly affected with immunologic and nonimmunologic factors. 1 Cyclosporine and tacrolimus are calcineurin inhibitors that can reduce the incidence of acute rejection, and are currently used in immunosuppressive therapy after Tx. [3][4][5][6] Cyclosporine and tacrolimus therapies have some adverse effects (eg, arterial hypertension and nephrotoxicity).…”

Section: Introductionmentioning

confidence: 99%

Untitled

2014

Exp Clin Transplant

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Objectives: Vascular noninflammatory molecule 1 is a plasma membrane enzyme, also known as pantetheinase. It has been shown that vascular noninflammatory molecule 1 urinary and serum concentrations of vascular noninflammatory molecule 1 increase in nephrotoxicant-induced renal injury before classic markers. Tacrolimus and cyclosporine used as immunosuppressive agents are nephrotoxic drugs. This study sought to investigate alterations of vascular noninflammatory molecule 1 levels after a kidney transplant. Materials and Methods: This study included 28 renal allograft recipients without acute rejection. Before transplant, and the first and sixth months after the transplant, vascular noninflammatory molecule 1 and creatinine levels were measured in renal transplant recipients using enzyme-linked immunosorbent assay and spectrophotometric methods. Results: During the first month after transplant, we observed a significant increase in vascular noninflammatory molecule 1 levels compared with previous levels (P < .0001). Also, during the sixth month, vascular noninflammatory molecule 1 levels were higher than values previously taken (P < .01), although they were lower compared with the first month values (P = .004). No correlation was found between vascular noninflammatory molecule 1 and creatinine before transplant or during the first and sixth months after transplant. When the patients were divided into subgroups according to the immunosuppressive drugs used, in tacrolimustreated patients, serum vascular noninflammatory molecule 1 levels were no different from the cyclosporine-administered levels measured at 3 different times. Conclusions: We conclude that serum vascular noninflammatory molecule 1 levels may be low in the end-stage renal failure and transiently increase after transplant owing to transient renal function deterioration, which does not lead to elevation of serum creatinine levels in renal transplant patients.

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Assessment of Cardiovascular Risk Factors after Renal Transplantation: A Step towards Reducing Graft Failure

Cited by 6 publications

References 54 publications

Fear of Movement and Low Self-Efficacy Are Important Barriers in Physical Activity after Renal Transplantation

Fear of Movement and Low Self-Efficacy Are Important Barriers in Physical Activity after Renal Transplantation

Dyslipidemia in Renal Transplant Recipients Treated With Cyclosporine A

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