Assessment of Cardiovascular Risks due to Methylphenidate in Six Months of Treatment in Children with Attention Deficit and Hyperactivity Disorder

Ari, Mehmet Emre; Çetin, İ̇brahim İ̇lker; Ekici, Filiz; Kocabaş, Abdullah; Eminoglu, Sancar; Güney, Esra; Öztürk, Önder; Dinç, Gülser Şenses; Göker, Zeynep

doi:10.5455/bcp.20140702010106

Cited by 2 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16,17 For example, the development of tic disorder, elongated QT durations or the onset of depression, psychosis and/or mania were identified in some MPH-treated individuals. 11,18 Furthermore, a recent comprehensive meta-analysis including 185 studies of MPH use for ADHD treatment reported a high frequency of non-serious adverse events associated with treatment, including for example, insomnia and loss of appetite. 19 Currently, no clinical guidelines exist to address these issues with a personalized approach for individualized medication.…”

Section: Introductionmentioning

confidence: 99%

Pharmacogenetics predictors of methylphenidate efficacy in childhood ADHD

2017

View full text Add to dashboard Cite

Stimulant medication has long been effective in treating attention-deficit/hyperactivity disorder (ADHD) and is currently the first-line pharmacological treatment for children. Both methylphenidate and amphetamine modulate extracellular catecholamine levels through interaction with dopaminergic, adrenergic and serotonergic system components; it is therefore likely that catecholaminergic molecular components influence the effects of ADHD treatment. Using meta-analysis, we sought to identify predictors of pharmacotherapy to further the clinical implementation of personalized medicine. We identified 36 studies (3647 children) linking the effectiveness of methylphenidate treatment with DNA variants. Pooled-data revealed a statistically significant association between single nucleotide polymorphisms (SNPs) rs1800544 ADRA2A (odds ratio: 1.69; confidence interval: 1.12-2.55), rs4680 COMT (odds ratio (OR): 1.40; confidence interval: 1.04-1.87), rs5569 SLC6A2 (odds ratio: 1.73; confidence interval: 1.26-2.37) and rs28386840 SLC6A2 (odds ratio: 2.93; confidence interval: 1.76-4.90), and, repeat variants variable number tandem repeat (VNTR) 4 DRD4 (odds ratio: 1.66; confidence interval: 1.16-2.37) and VNTR 10 SLC6A3 (odds ratio: 0.74; confidence interval: 0.60-0.90), whereas the following variants were not statistically significant: rs1947274 LPHN3 (odds ratio: 0.95; confidence interval: 0.71-1.26), rs5661665 LPHN3 (odds ratio: 1.07; confidence interval: 0.84-1.37) and VNTR 7 DRD4 (odds ratio: 0.68; confidence interval: 0.47-1.00). Funnel plot asymmetry among SLC6A3 studies was identified and attributed largely to small study effects. Egger's regression test and Duval and Tweedie's 'trim and fill' were used to examine and correct for publication bias. These findings have major implications for advancing our therapeutic approach to childhood ADHD treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

Pharmacogenetics predictors of methylphenidate efficacy in childhood ADHD

2017

View full text Add to dashboard Cite

show abstract

Evaluation of Frontal QRS-T Angle in Children With ADHD and Healthy Controls

Kılıçaslan,

Tan,

Tanriverdi

2024

J Atten Disord

View full text Add to dashboard Cite

Introduction: Conflicting findings exist regarding the link between attention deficit hyperactivity disorder (ADHD) and cardiovascular diseases. This study aimed to evaluate the frontal QRS-T (fQRS-T) angle and its correlation with symptom severity in children diagnosed with ADHD. Methods: The study population consisted of 172 patients diagnosed with ADHD (120 drug naive and 52 drug positive) and 82 healthy controls. ADHD symptoms were assessed using the Atilla Turgay DSM-IV-Based Screening and Assessment Scale for Disruptive Conduct Disorders (T-DSM-IV-Scale). The fQRS-T angle and corrected QT (QTc) interval were obtained from the automated reports of 12-lead electrocardiography device for each patient. Results: QTc interval and fQRS-T angle were significantly different among the groups. Post hoc analyses showed that QTc interval and fQRS-T angle of ADHD drug naive and ADHD drug positive patients were significantly higher than the healthy control groups. However, there was no significant difference between drug naive and drug positive patients regarding QTc interval and fQRS-T angle. Both QTc interval and fQRS-T angle showed positive correlations with the severity of ADHD symptoms (r = 0.263, p = .001 and r = 0.175, p = .023 respectively). Conclusion: We found that fQRS-T angle was significantly wider in children with ADHD. Therefore, we suggest that fQRS-T angle may help in cardiovascular risk assessment in children with ADHD.

show abstract

Assessment of Cardiovascular Risks due to Methylphenidate in Six Months of Treatment in Children with Attention Deficit and Hyperactivity Disorder

Abstract: ÖZET:Dikkat eksikliği hiperaktivite bozukluğu olan çocuklarda metilfenidat tedavisinin altıncı ayında kardiyovasküler risklerin değerlendirilmesi

Cited by 2 publications

References 17 publications

Pharmacogenetics predictors of methylphenidate efficacy in childhood ADHD

Pharmacogenetics predictors of methylphenidate efficacy in childhood ADHD

Evaluation of Frontal QRS-T Angle in Children With ADHD and Healthy Controls

Contact Info

Product

Resources

About