Assessment of care pattern and outcome in hemangioblastoma

Huang, Yuqian; Chan, Louis Yik-Si; Bai, Harrison X.; Li, Xuejun; Zhang, Zishu; Wang, Yinyan; Cao, Yang; Karakousis, Giorgos C.; Huang, Raymond Y.; Xiao, Bo; Zhang, Paul J.; Yang, Li

doi:10.1038/s41598-018-29047-9

Cited by 18 publications

(16 citation statements)

References 38 publications

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“…Gross total resection is the most suitable treatment if an intervention is required. [ 45 ] If a correct preoperative diagnosis was made, these 2 patients may have received different treatments. Unfortunately, RH can easily be misdiagnosed as renal clear cell carcinoma, the most common malignant tumor of the kidney, which can lead to overtreatment.…”

Section: Discussionmentioning

confidence: 99%

CT and MRI characteristic findings of sporadic renal hemangioblastoma

He¹,

Liu²,

Liu

et al. 2021

Medicine

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Rationale: Hemangioblastomas in the kidney are rare. Although a few cases of renal hemangioblastoma (RH) have been reported, the content of these articles mainly focused on clinical and pathological research, with minimal descriptions of radiologic findings. Moreover, there are no descriptions of magnetic resonance imaging (MRI) with enhancement of this condition. Herein, we report 2 cases of RH with computed tomography (CT) and MRI findings. Patient concerns: Two patients presented to our institution because of dull pain in the left abdomen, and a mass in the left kidney was found by ultrasound examination in each case. The patient had no special family history. Physical examination revealed no obvious tenderness or percussion pain in the renal and ureteral walking areas, and there was no obvious mass. Routine blood and urine tests were normal, and the serum tumor markers were negative. No obvious lesions were found on imaging of the other body parts. Diagnosis: Similar radiologic findings were observed in both cases and mimicked those of cavernous hemangiomas of the liver, including peripheral nodular enhancement in the corticomedullary phase, progressive centripetal enhancement in the nephrographic and delayed phases, and occasional complete “filling in” in the delayed phase. We made a radiologic diagnosis of renal clear cell carcinoma for patient 1 and suspected renal clear cell carcinoma for patient 2, but the pathological results showed RH. Interventions: Given the suspicion of renal cell carcinoma, both patients underwent partial nephrectomy. Outcome: The recovery of the two patients was uneventful, and there was no evidence of local recurrence or metastasis many years after surgery. Lessons: RH is a rare benign tumor that can be easily misdiagnosed as clear cell carcinoma. Characteristic CT and MRI manifestations may improve preoperative diagnostic accuracy to avoid surgery or indicate nephron-sparing surgery.

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Section: Discussionmentioning

confidence: 99%

CT and MRI characteristic findings of sporadic renal hemangioblastoma

He¹,

Liu²,

Liu

et al. 2021

Medicine

View full text Add to dashboard Cite

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“…Because RHs are indolent neoplasms, asymptomatic tumors may be managed with observation. Gross total resection is the most suitable treatment if intervention is required [45]. If the correct preoperative diagnosis was made, these two patients may have received different treatments.…”

Section: Discussionmentioning

confidence: 99%

CT and MRI Characteristic Findings of Sporadic Renal Hemangioblastoma: Two Case Reports and Review of the Literature

Liu

et al. 2020

Preprint

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BackgroundHemangioblastoma in the kidney is rare. Although a few renal hemangioblastoma cases have been reported, the content of these articles mainly focused on clinical and pathological research, with minimal descriptions of radiologic findings. Moreover, there are no descriptions of magnetic resonance imaging with enhancement for this condition. We herein report two cases of renal hemangioblastoma with computed tomography and magnetic resonance imaging findings.Case presentationTwo patients presented to our institution due to dull pain of the left abdomen, and a mass in the left kidney was found by ultrasound examination in each case. They had no special family history. Physical examination revealed no obvious tenderness or percussion pain in the renal region and ureteral walking area, and there was no obvious mass. Routine blood and urine tests were normal, and serum tumor markers were negative. No obvious lesions were found on imaging of other body parts. Similar radiologic findings were observed in both cases and mimicked those of cavernous hemangiomas of the liver, including peripheral nodular enhancement in the corticomedullary phase, progressive centripetal enhancement in the nephrographic and delayed phases, and occasional complete “filling in” in the delayed phase. Given the suspicion for renal cell carcinoma, both patients underwent partial nephrectomy. The pathological results showed renal hemangioblastoma.ConclusionsRenal hemangioblastoma is a rare benign tumor that is easily misdiagnosed as clear cell carcinoma. Characteristic computed tomography and magnetic resonance imaging manifestations may improve preoperative diagnostic accuracy to avoid surgery or indicate nephron-sparing surgery.

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“…However, independent predictors of overall survival include surgical management, younger age and Caucasian race, while radiation therapy outcomes were not validated (possibly owing to short follow-up and HB growth patterns) in a SEER-based analysis [ 64 ]. A 2018 paper supports gross total resection as the gold standard, and suggests SRS has comparable outcomes to subtotal resection only [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Intermixed arteriovenous malformation and hemangioblastoma: case report and literature review

et al. 2020

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We report the third presentation of an intermixed arteriovenous malformation and hemangioblastoma. The rare occurrence of the diagnostic histologic features of both a neoplasm and vascular malformation in a single lesion is more common in gliomas, as angioglioma, and is termed an 'intermixed’ lesion. We review the literature concerning the developmental biology of each lesion, and potential interplay in the formation of an intermixed vascular neoplasm and vascular malformation. The roles of cellular origin, genetic susceptibility, favourable microenvironment, altered local gene expression and key regulatory pathways are reviewed. Our review supports angiography and genetic profiling in intermixed lesions to inform management strategies. Consideration should be given to multimodality therapeutic interventions as required, including microsurgical resection, stereotactic radiosurgery and further research to exploit emerging molecular targets.

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Assessment of care pattern and outcome in hemangioblastoma

Cited by 18 publications

References 38 publications

CT and MRI characteristic findings of sporadic renal hemangioblastoma

CT and MRI characteristic findings of sporadic renal hemangioblastoma

CT and MRI Characteristic Findings of Sporadic Renal Hemangioblastoma: Two Case Reports and Review of the Literature

Intermixed arteriovenous malformation and hemangioblastoma: case report and literature review

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