Variations of great Saphenous Vein are clinically important because of its role in varicose veins recurrence and as application as an autograft for coronary angioplasty. The incidence of Great Saphenous Vein duplication cited in medical literature ranges from 0.97% to 49%. The present case discusses a rare duplicated and mesh appearance of Great Saphenous vein and its clinical applications. Great Saphenous Vein and its duplication, both started separately from dorsal venous arch of left foot in a 60 years old male cadaver during routine dissection. They were connected by three venous communications during their course and drained as a single vein at saphenofemoral junction after uniting at the level of apex of femoral triangle. Thorough understanding of anatomical variations of great saphenous vein and its tributaries are important ensuring the effective diagnosis and treatment of varicose veins.