Assessment of cellular and serum proteome from tongue squamous cell carcinoma patient lacking addictive proclivities for tobacco, betel nut, and alcohol: Case study

Khowal, Sapna; Naqvi, Samar Husain; Monga, Seema; Jain, Swatantra Kumar; Wajid, Saima

doi:10.1002/jcb.26554

Cited by 19 publications

(15 citation statements)

References 244 publications

(573 reference statements)

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“…Importantly, the lack of response in these subjects includes evidence for increases in miRNAs together with the downregulation of their corresponding gene targets. Among these miRNA gene targets were genes associated with cancer [e.g., IFI44L (36), RGL1 (37), MARCH1 (42), and MRPL17 (39)] and antiviral activity [e.g., IFIT5 (57) and TLR7 (1)]. Taken together with the upregulation of miRNAs (e.g., miR-155, let-7e, miR-370, miR-192, and miR-1275) that target IFN-inducible antiviral effector molecules (43), it is interpreted that these subjects may exemplify a response profile to Peg-IFN-a2a that would predict a return of plasma viral load, as was observed upon ART interruption.…”

Section: Discussionmentioning

confidence: 99%

NK Response Correlates with HIV Decrease in Pegylated IFN-α2a–Treated Antiretroviral Therapy–Suppressed Subjects

Papasavvas

Azzoni

Kossenkov

et al. 2019

The Journal of Immunology

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We previously reported that pegylated IFN-a2a (Peg-IFN-a2a) added to antiretroviral therapy (ART)-suppressed, HIV-infected subjects resulted in plasma HIV control and integrated HIV DNA decrease. We now evaluated whether innate NK cell activity or PBMC transcriptional profiles were associated with decreases in HIV measures. Human peripheral blood was analyzed prior to Peg-IFN-a2a administration (ART, baseline), after 5 wk of ART+Peg-IFN-a2a, and after 12 wk of Peg-IFN-a2a monotherapy (primary endpoint). After 5 wk of ART+Peg-IFN-a2a, immune subset frequencies were preserved, and induction of IFNstimulated genes was noted in all subjects except for a subset in which the lack of IFN-stimulated gene induction was associated with increased expression of microRNAs. Viral control during Peg-IFN-a2a monotherapy was associated with 1) higher levels of NK cell activity and IFN-g-induced protein 10 (IP-10) on ART (preimmunotherapy) and 2) downmodulation of NK cell KIR2DL1 and KIR2DL2/DL3 expression, transcriptional enrichment of expression of genes associated with NK cells in HIV controller subjects, and higher ex vivo IFN-a-induced NK cytotoxicity after 5 wk of ART+Peg-IFN-a2a. Integrated HIV DNA decline after immunotherapy was also associated with gene expression patterns indicative of cell-mediated activation and NK cytotoxicity. Overall, an increase in innate activity and NK cell cytotoxicity were identified as correlates of Peg-IFN-a2a-mediated HIV control.

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Section: Discussionmentioning

confidence: 99%

NK Response Correlates with HIV Decrease in Pegylated IFN-α2a–Treated Antiretroviral Therapy–Suppressed Subjects

Papasavvas

Azzoni

Kossenkov

et al. 2019

The Journal of Immunology

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“…Whether in the TCGA-LUAD cohort or the three GEO cohorts for external verification, the seven-gene signature exhibited excellent performance for LUAD prognosis. Although previous studies have shown that the signature genes were related to a variety of cancers (liver cancer, breast cancer, oral cancer, and others), there have been few studies on the mechanism through which they participate in cancer progression (Li et al, 2017;Khowal et al, 2018;Uddin et al, 2018;Yao et al, 2019). Migration, proliferation, energy metabolism, and autophagy are all considered regulatory targets, but the underlying mechanism remains to be further elucidated (Hosgood et al, 2008;Wei et al, 2015;Jaiswal et al, 2018;Ma et al, 2020;Wang et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Significance of Parkinson Family Genes in the Prognosis and Treatment Outcome Prediction for Lung Adenocarcinoma

Xiao

Zhang

et al. 2021

Front. Mol. Biosci.

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Epidemiological investigations have shown that patients with Parkinson’s disease (PD) have a lower probability of developing lung cancer. Subsequent research revealed that PD and lung cancer share specific genetic alterations. Therefore, the utilisation of PD biomarkers and therapeutic targets may improve lung adenocarcinoma (LUAD) diagnosis and treatment. We aimed to identify a gene-based signature from 25 Parkinson family genes for LUAD prognosis and treatment choice. We analysed Parkinson family gene expression and protein levels in LUAD, utilising multiple databases. Least absolute shrinkage and selection operator (LASSO) regression was used to construct a prognostic model based on the TCGA-LUAD cohort. We validated the model in external GEO cohorts. Immune cell infiltration was compared between risk groups, and GEO data was used to explore the model’s predictive ability for LUAD treatment response. Nearly all Parkinson family genes exhibited significant differential expression between LUAD and normal tissues. LASSO regression confirmed that our seven Parkinson family gene-based signature had excellent prognostic performance for LUAD, as validated in three GEO cohorts. The high-risk group was clearly associated with low tumour immune cell infiltration, suggesting that immunotherapy may not be an optimal treatment choice. This is the first Parkinson family gene-based model for the prediction of LUAD prognosis and treatment outcome. The association of these genes with poor prognosis and low immune infiltration requires further investigation.

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“…In addition, HPV16 DNA enhancers may cause activation of proto‐oncogenes, thereby, HPV16 integration may interfere with signaling networks functional in maintaining normal physiology of oral mucosa . Further studies are needed to elucidate the role of integration of HPV16 genome in OSCC with signaling networks, and the involvement of HPV genome variants in viral carcinogenesis in the oral cavity …”

Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus type 16 in persistent oral lesions arising in patients with tobacco, areca nut, and alcohol habits

Khowal

Jain

Wajid

2019

Oral Science International

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Background and purpose Human papillomavirus (HPV) has been shown to be associated with oral malignancies. The purpose of this study was to detect HPV and a high‐risk type HPV16 viral DNA in 24 cases with oral squamous cell carcinoma (OSCC) and 15 cases with non‐OSCC persistent oral lesions (POL) residing in North India. The diagnosis was determined by the histopathological characteristics of the oral biopsy. Results All oral lesions were HPV‐DNA positive, and the HPV16‐positive ratios of OSCC and non‐OSCC POLs were 50% and 53%, respectively. Approximately 62% of moderately differentiated OSCC and 36% of well‐differentiated OSCC were HPV16 positive. Evaluated odds and prevalence ratios >1 indicated a higher prevalence of HPV16 infection in patients with tobacco, areca nut, and/or alcohol habits, compared with nonaddicts. The obtained P‐values were higher than 0.05, indicating that the relationship is statistically insignificant, which may be due to lower number of POL cases. This study could not conclude that HPV16 infection plays an essential role in malignant transformation of the oral mucosa, raising a need for further experimental endeavors. Conclusions This study indicates that HPV16 infection in OSCC and non‐OSCC POLs frequently occurred in people with tobacco smoking, tobacco‐areca nut chewing, and alcohol intake. These fallacious habits may increase HPV16 infection in the oral cavity.

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Assessment of cellular and serum proteome from tongue squamous cell carcinoma patient lacking addictive proclivities for tobacco, betel nut, and alcohol: Case study

Cited by 19 publications

References 244 publications

NK Response Correlates with HIV Decrease in Pegylated IFN-α2a–Treated Antiretroviral Therapy–Suppressed Subjects

NK Response Correlates with HIV Decrease in Pegylated IFN-α2a–Treated Antiretroviral Therapy–Suppressed Subjects

Significance of Parkinson Family Genes in the Prognosis and Treatment Outcome Prediction for Lung Adenocarcinoma

Prevalence of human papillomavirus type 16 in persistent oral lesions arising in patients with tobacco, areca nut, and alcohol habits

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