Assessment of cerebral blood perfusion reserve with acetazolamide using 3D spiral ASL MRI: Preliminary experience in pediatric patients

Hu, Houchun H.; Li, Zhiqiang; Pokorney, Amber; Chia, Jonathan M.; Stefani, Niccolo; Pipe, James G.; Miller, Jeffrey H

doi:10.1016/j.mri.2016.08.019

Cited by 18 publications

(9 citation statements)

References 60 publications

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“…Spiral MRI promises many benefits including high acquisition and SNR efficiency, short minimum echo‐times, robustness to motion and flow, and higher geometric fidelity (compared to EPI). In the past few years, spiral has been shown to provide unique capabilities or substantial advantages over conventional imaging in post‐Gad T 1 weighted imaging, 3D TSE imaging, cardiac flow imaging, diffusion weighted imaging, real‐time imaging, perfusion imaging, functional MRI, MR fingerprinting, and many other applications. Despite its potential and long history, spiral MRI has struggled to find widespread clinical adoption, in large part due to artifacts from susceptibility‐induced field inhomogeneity and eddy current‐induced gradient errors.…”

Section: Introductionmentioning

confidence: 99%

Correction of B₀ eddy current effects in spiral MRI

Robison

Wang

et al. 2018

Magnetic Resonance in Med

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Purpose B0 eddy currents are a subtle but important source of artifacts in spiral MRI. This study illustrates the importance of addressing these artifacts and presents a system response‐based eddy current correction strategy using B0 eddy current phase measurements on a phantom. Methods B0 and linear eddy current system response measurements were estimated from phantom‐based measurement and used to predict residual eddy current effects in spiral acquisitions. The measurements were evaluated across multiple systems and gradient sets. The corresponding eddy current corrections were studied in both axial spiral‐in/out TSE and sagittal spiral‐out MPRAGE volunteer data. Results Correction of B0 eddy currents using the proposed method mitigated blurriness in the axial spiral‐in/out images and artifacts in the sagittal spiral‐out images. The system response measurement was found to yield repeatable results over time with some variation in the B0 eddy current responses measured between different systems. Conclusions The proposed eddy current correction framework was effective in mitigating the effects of residual B0 and linear eddy currents. Any spiral acquisition should take residual eddy currents into account. This is particularly important in spiral‐in/out acquisitions.

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Section: Introductionmentioning

confidence: 99%

Correction of B₀ eddy current effects in spiral MRI

Robison

Wang

et al. 2018

Magnetic Resonance in Med

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“…As a noninvasive imaging tool, MRI is now widely used in hospitals for disease diagnosis, and can provide a three-dimensional anatomical image without exposing the body to ionizing radiation. 30 Fe 3 O 4 NPs are commonly used as MRI contrast agents because they have the ability to shorten the T 2 relaxation time of surrounding water. 31 …”

Section: Resultsmentioning

confidence: 99%

Construction of Multifunctional Fe₃O₄-MTX@HBc Nanoparticles for MR Imaging and Photothermal Therapy/Chemotherapy

Zhang

Shan

et al. 2018

Nanotheranostics

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To accomplish effective cancer imaging and integrated therapy, the multifunctional nanotheranostic Fe3O4-MTX@HBc core-shell nanoparticles (NPs) were designed. A straightforward method was demonstrated for efficient encapsulation of magnetic NPs into the engineered virus-like particles (VLPs) through the affinity of histidine tags for the methotrexate (MTX)-Ni2+ chelate. HBc144-His VLPs shell could protect Fe3O4-MTX NPs from the recognition by the reticuloendothelial system as well as could increase their cellular uptake efficiency. Through our well-designed tactic, the photothermal efficiency of Fe3O4 NPs were obviously improved in vitro and in vivo upon near-infrared (NIR) laser irradiation. Moreover, Magnetic resonance imaging (MRI) results showed that the Fe3O4-MTX@HBc core-shell NPs were reliable T2-type MRI contrast agents for tumor imaging. Hence the Fe3O4-MTX@HBc core-shell NPs may act as a promising theranostic platform for multimodal cancer treatment.

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“…In addition, particular sequences can be used to provide correlations with intracranial variables. Specifically, arterial spin labeling can be used to determine CBF in children (28); however, these are only at the stage of preliminary testing and have yet to be brought forward into clinical practice.…”

Section: Neuroimagingmentioning

confidence: 99%

Multimodality neuromonitoring in severe pediatric traumatic brain injury

et al. 2017

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Each year, the annual hospitalization rates of traumatic brain injury (TBI) in children in the United States are 57.7 per 100K in the <5 years of age and 23.1 per 100K in the 5-14 years age group. Despite this, little is known about the pathophysiology of TBI in children and how to manage it most effectively. Historically, TBI management has been guided by clinical examination. This has been assisted progressively by clinical imaging, intracranial pressure (ICP) monitoring, and finally a software that can calculate optimal brain physiology. Multimodality monitoring affords clinicians an early indication of secondary insults to the recovering brain including raised ICP and decreased cerebral perfusion pressure. From variables such as ICP and arterial blood pressure, correlations can be drawn to determine parameters of cerebral autoregulation (pressure reactivity index) and "optimal cerebral perfusion pressure" at which the vasculature is most reactive. More recently, significant advances using both direct and near-infrared spectroscopy-derived brain oxygenation plus cerebral microdialysis to drive management have been described. Here in, we provide a perspective on the state-of-the-art techniques recently implemented in clinical practice for pediatric TBI.

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Assessment of cerebral blood perfusion reserve with acetazolamide using 3D spiral ASL MRI: Preliminary experience in pediatric patients

Cited by 18 publications

References 60 publications

Correction of B₀ eddy current effects in spiral MRI

Correction of B₀ eddy current effects in spiral MRI

Construction of Multifunctional Fe₃O₄-MTX@HBc Nanoparticles for MR Imaging and Photothermal Therapy/Chemotherapy

Multimodality neuromonitoring in severe pediatric traumatic brain injury

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Assessment of cerebral blood perfusion reserve with acetazolamide using 3D spiral ASL MRI: Preliminary experience in pediatric patients

Cited by 18 publications

References 60 publications

Correction of B0 eddy current effects in spiral MRI

Correction of B0 eddy current effects in spiral MRI

Construction of Multifunctional Fe3O4-MTX@HBc Nanoparticles for MR Imaging and Photothermal Therapy/Chemotherapy

Multimodality neuromonitoring in severe pediatric traumatic brain injury

Contact Info

Product

Resources

About

Correction of B₀ eddy current effects in spiral MRI

Correction of B₀ eddy current effects in spiral MRI

Construction of Multifunctional Fe₃O₄-MTX@HBc Nanoparticles for MR Imaging and Photothermal Therapy/Chemotherapy