Assessment of Cervical Lymph Node Metastasis with Different Imaging Methods in Patients with Head and Neck Squamous Cell Carcinoma

Akoğlu, Ertap; Dutipek, Murat; Bekiş, Recep; Degirmenci, Berna; Ada, Emel; Güneri, Ataman

doi:10.2310/7070.2005.34605

Cited by 46 publications

(30 citation statements)

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“…In the OBS group, these range from 11% to 42 % and in the END group, from 12% to 30% (Table 2). This observed difference within each group might be due to the availability of more sophisticated investigative tools for the early identification of neck node metastasis with better sensitivity and specificity in recent times [3,16,83,167,168]. Some of the occult metastasis could now be better detected during evaluation and properly staged.…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

et al. 2011

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Section: Discussionmentioning

confidence: 99%

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

et al. 2011

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“…To detect any differences for SEN, SPE, AUC, and Q* between CT and MRI, a Z-test was conducted (Z= (VAL1–VAL2)/SQRT (SE12+SE22). The test standard was set at α=0.05.…”

Section: Methodsmentioning

confidence: 99%

“…The presence of cervical lymph node metastasis may affect the optimal treatment choice as well as prognosis in patients 2. Management of patients presenting with cervical lymph node metastasis includes selective or radical neck dissection, followed by radiotherapy and/or chemotherapy depending on the pathological findings of the nodes 3–5.…”

Section: Introductionmentioning

confidence: 99%

Computed tomography versus magnetic resonance imaging for diagnosing cervical lymph node metastasis of head and neck cancer: a systematic review and meta-analysis

Sun¹,

Li²,

Li³

et al. 2015

OTT

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Computed tomography (CT) and magnetic resonance imaging (MRI) are common imaging methods to detect cervical lymph node metastasis of head and neck cancer. We aimed to assess the diagnostic efficacy of CT and MRI in detecting cervical lymph node metastasis, and to establish unified diagnostic criteria via systematic review and meta-analysis. A systematic literature search in five databases until January 2014 was carried out. All retrieved studies were reviewed and eligible studies were qualitatively summarized. Besides pooling the sensitivity (SEN) and specificity (SPE) data of CT and MRI, summary receiver operating characteristic curves were generated. A total of 63 studies including 3,029 participants were involved. The pooled results of meta-analysis showed that CT had a higher SEN (0.77 [95% confidence interval {CI} 0.73–0.87]) than MRI (0.72 [95% CI 0.70–0.74]) when node was considered as unit of analysis (P<0.05); MRI had a higher SPE (0.81 [95% CI 0.80–0.82]) than CT (0.72 [95% CI 0.69–0.74]) when neck level was considered as unit of analysis (P<0.05) and MRI had a higher area under concentration-time curve than CT when the patient was considered as unit of analysis (P<0.05). With regards to diagnostic criteria, for MRI, the results showed that the minimal axial diameter of 10 mm could be considered as the best size criterion, compared to 12 mm for CT. Overall, MRI conferred significantly higher SPE while CT demonstrated higher SEN. The diagnostic criteria for MRI and CT on size of metastatic lymph nodes were suggested as 10 and 12 mm, respectively.

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“…30 It is well established in the literature that clinical examination alone is not able to correctly identify cervical metastatic lymph nodes. 31,32 In the present study, clinical evaluation yielded more negative necks than both CECT and MRI. The detection of clinically occult metastases by imaging modalities might be invaluable, since many patients initially classified clinically with no neck metastases (cN0) have, in fact, occult metastatic disease (pN1), detected by histopathological analysis.…”

Section: Discussionmentioning

confidence: 47%

Contrast-enhanced CT and MRI for detecting neck metastasis of oral cancer: comparison between analyses performed by oral and medical radiologists

Figueiredo

Leite²,

Barra³

et al. 2012

Dentomaxillofacial Radiology

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Objectives: The aim of the study was to verify the concordance of contrast-enhanced CT (CECT) and MRI evaluation among four radiologists in detecting metastatic cervical lymph nodes of oral cancer patients. Methods: Ten patients underwent clinical and imaging examinations (CECT and MRI). Four radiologists, two oral and maxillofacial radiologists (OMRs) and two medical radiologists (MRs), independently analysed the images twice. Cohen's kappa index and Wilcoxon signed-rank test were used to verify the concordance between all analyses. Results: Regarding the interobserver agreement, the OMRs presented excellent kappa values for determining the regional lymph nodes (N-stage) in both CECT and MRI. The MRs presented moderate agreement for CECT evaluation at the first reading, but no concordance was found for the other analyses. When each imaging modality was analysed separately, kappa values were higher between all examiners. Greater variability was demonstrated between Nstage evaluation using different examinations. All radiologists were able to identify a greater number of metastatic lymph nodes in CECT than in MRI, except one MR, but no significant difference was found for all readers. The differences between the number of metastatic lymph nodes among all radiologists were not statistically significant. Moderate intraobserver agreement was observed for CECT and MRI evaluation, except for one MR. Conclusions: The differences found between the N-stage performed by OMRs and MRs support the necessity of a multidisciplinary approach in the imaging evaluation of metastatic nodes. Further studies are necessary to confirm which imaging modality should be employed when evaluating neck areas.

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Assessment of Cervical Lymph Node Metastasis with Different Imaging Methods in Patients with Head and Neck Squamous Cell Carcinoma

Cited by 46 publications

References 0 publications

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

Computed tomography versus magnetic resonance imaging for diagnosing cervical lymph node metastasis of head and neck cancer: a systematic review and meta-analysis

Contrast-enhanced CT and MRI for detecting neck metastasis of oral cancer: comparison between analyses performed by oral and medical radiologists

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Assessment of Cervical Lymph Node Metastasis with Different Imaging Methods in Patients with Head and Neck Squamous Cell Carcinoma

Cited by 46 publications

References 0 publications

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

Computed tomography versus magnetic resonance imaging for diagnosing cervical lymph node metastasis of head and neck cancer: a&nbsp;systematic review and meta-analysis

Contrast-enhanced CT and MRI for detecting neck metastasis of oral cancer: comparison between analyses performed by oral and medical radiologists

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Computed tomography versus magnetic resonance imaging for diagnosing cervical lymph node metastasis of head and neck cancer: a systematic review and meta-analysis