Assessment of changes in regional cerebral blood flow in patients with major depression using the 99mTc-HMPAO single photon emission tomography method

Yazıcı, M. Kâzım; Kapucu, Özlem; Erbaş, Belkıs; Varoglu, Erhan; Güleç, Cengiz; Bekdik, Coskun

doi:10.1007/bf00180865

Cited by 66 publications

(24 citation statements)

References 25 publications

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“…Among these reports, the most consistent findings are hypoperfusion and hypometabolism in the anterior brain structures, especially in the prefrontal cortex [1][2][3][4][5][6][7][8][9][10][11] and the anterior paralimbic regions, [9][10][11][12][13] and similar findings have also been reported in late-life depression. [14][15][16][17] However, the clinical significance of these findings remains controversial.…”

Section: Introductionsupporting

confidence: 55%

Changes in regional cerebral blood flow abnormalities in late‐life depression following response to electroconvulsive therapy

Awata

Konno

Kawashima

et al. 2002

Psychiatry Clin Neurosci

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The impact of electroconvulsive therapy (ECT) on the regional cerebral blood flow (rCBF) abnormalities in late-life depression is still unknown and the clinical significance of these findings in late-life depression has not been fully discussed. Using single photon emission computed tomography (SPECT) with 99m Tc-hexamethylpropylene amine oxime ( 99m Tc-HMPAO), we examined the changes of rCBF patterns in nine late-life patients with major depressive episodes before and following response to ECT compared with nine age-and sex-matched healthy volunteers. Statistical comparisons were made on both region-of-interest (ROI) and voxel-by-voxel bases. In ROI-based analyses, a mean rCBF was significantly decreased in the patients before ECT compared with the control, significantly increased (normalized) in the patients 2 weeks after ECT compared with that before ECT, and still increased in the patients 12 weeks after ECT compared with that before ECT. In voxel-by-voxel analyses, a significant rCBF reduction was found in the bilateral pre-and subcallosal anterior cingulate cortex, the bilateral caudal orbitofrontal cortex, the right insular cortex and the right posterior middle frontal gyrus in patients before ECT compared with the control, and similar rCBF patterns were shown at 2 weeks and 12 weeks after ECT. We propose the hypothesis that a mean rCBF reduction may have a state-related property while persistent anterior paralimbic hypoperfusion may have a trait-like property, which relates to the relapse vulnerability as well as a tendency toward medication failure and illness chronicity in late-life depression.

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Section: Introductionsupporting

confidence: 55%

Changes in regional cerebral blood flow abnormalities in late‐life depression following response to electroconvulsive therapy

Awata

Konno

Kawashima

et al. 2002

Psychiatry Clin Neurosci

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“…This was mainly applicable to psychotic symptoms rated on the BPRS. While associations between increased severity of illness and reduced blood flow have been described previously, they have mostly involved patients with depression and ratings on the HDRS (Yazici et al 1992;Scott et al 1994;Bonne et al 1996). Then again, some SPECT studies have found that patients with psychotic symptoms show significantly decreased rCBF relative to both non-psychotic patients and healthy controls (Skaf et al2002;Gonul et al 2004;Benbarre et al 2005).…”

Section: Patterns Of Rcbf Among Patients and Controls In The Current mentioning

confidence: 93%

A single photon emission computerized tomography (SPECT) study of regional cerebral blood flow in bipolar disorder

Bhardwaj

Chakrabarti

Mittal

et al. 2010

The World Journal of Biological Psychiatry

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Data on functional imaging of bipolar disorder (BD) utilizing single photon emission computerized tomography (SPECT) is limited. This study assessed regional cerebral blood flow (rCBF), using (99m)Tc-ECD SPECT, among patients with BD, with mania (N=10) or depression (N=10), compared with 10 patients with unipolar depression and 10 normal controls. Regions of interest were analysed using a semi-automatic brain quantification programme. Compared to controls, patients with mania had significantly reduced perfusion mainly in the left frontal area, also in the left anterior cingulate and parietal cortices; those with bipolar depression had significantly lowered rCBF principally in the anterior temporal regions bilaterally, as well as the left parietal area. Patients with unipolar depression had significantly lowered perfusion than controls in most of the regions examined, chiefly in the anterior temporal and frontal cortices bilaterally; they also had lowered perfusion in the right anterior temporal and frontal areas, as well as the right middle temporal area and the right thalamus, compared to patients with mania. Increased severity of psychotic symptoms was associated with reduced rCBF in patients. These results indicate that altered blood flow in the frontal-subcortical systems characterises patients with BD, as well as those with unipolar depression.

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“…Cortex limits in selected cross-sections were determined through semi-automatic program, and the enumerations in the region of interest (ROI) were recorded as average enumeration. 6 pieces of ROI were placed in both sections [24] (Figure 2). Statistical analysis The data were analyzed using the Statistical Package for the Social Sciences (SPSS) for Windows, Version 18.0 software.…”

Section: Methodsmentioning

confidence: 99%

Assessment of regional cerebral blood flow in patients with early and late onset alcohol dependence: a SPECT study

Erdoğan¹,

Vardar²,

Altun³

et al. 2018

Journal of Surgery and Medicine

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How to cite / Atıf için: Erdoğan E, Vardar E, Altun GD, Fırat MF. Assessment of regional cerebral blood flow in patients with early and late onset alcohol dependence: SPECT study. J Surg Med. 2018;2(3):257-261. AbstractAim: Alcohol dependence has negative effects on the structure and functionality of the brain. The age of onset of alcohol is an important parameter in the grouping of alcoholics. The aim of this study is to compare whether regional cerebral blood flow (r-CBF) values differ between early (EO) versus late onset (LO) alcoholic patients. Methods: A total of 33 male patients with alcohol dependence as per DSM-IV criteria and 13 healthy controls were enrolled for the study. Regional measures of cortical cerebral blood flow were assessed using a high resolution Tc99m-HMPAO single photon emission computed tomography (SPECT). Alcoholic subjects were divided into two groups according to onset of problematic alcohol drinking age.Results: When three groups were compared, r-CBF differences were obtained in inferior frontal, inferior temporal, inferior left occipital and middle left frontal regions. Decreased r-CBF values were found in LO group when they compared to controls in both lower frontal and temporal regions (p<0.05). LO group showed significant reduced r-CBF values in regions of inferior frontal and temporal, inferior left occipital and middle left frontal when compared with EO. Conclusion: Our findings revealed that, there were differences in r-CBF values in EO and LO alcoholics at early abstinence period. These findings suggest that frontal lobes have a key role in alcoholism neurobiology, as noted in previous studies. Repeating the measurements after a long-term abstinence will be useful in revealing differences among the alcoholic groups.

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Assessment of changes in regional cerebral blood flow in patients with major depression using the 99mTc-HMPAO single photon emission tomography method

Cited by 66 publications

References 25 publications

Changes in regional cerebral blood flow abnormalities in late‐life depression following response to electroconvulsive therapy

Changes in regional cerebral blood flow abnormalities in late‐life depression following response to electroconvulsive therapy

A single photon emission computerized tomography (SPECT) study of regional cerebral blood flow in bipolar disorder

Assessment of regional cerebral blood flow in patients with early and late onset alcohol dependence: a SPECT study

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