Assessment of Cholesterol, Glycemia Control and Short- and Long-Term Antihypertensive Effects of Smooth Hound Viscera Peptides in High-Salt and Fructose Diet-Fed Wistar Rats

Abstract

In this study, the antihypertensive activity of Purafect®-smooth hound viscera protein hydrolysate (VPH) and its peptide fraction with molecular weight (MW) below 1 kDa (VPH-I) was investigated. In addition, the lipase inhibitory activity, as well the anticoagulant potential, in vitro, were assessed. The antihypertensive effects of VPH and VPH-I were studied during 24 h (short-term effect) and 30 days (long-term effect) using high-salt (18% NaCl) and -fructose (10%) diet (HSFD)-induced hypertension. Data showed that, 4 h post-administration of VPH and VPH-I (200 mg/kg BW), the systolic blood pressure of rats was reduced by about 6 and 9 mmHg, respectively. These effects were similar to that obtained with Captopril (~9 mmHg at t = 4 h). On the other hand, exposing the rats to daily to HSFD, coupled to the administration of viscera peptides, was found to attenuate hypertension. In addition, the proteins’ treatments were able to correct lipid and glycemic disorders, by reducing the total cholesterol and triglyceride contents and resorting to the plasma glucose level, compared to the HSFD group. Overall, the present findings demonstrated the preventive effect of VPH-peptides from hypertension complications, as a result of their biological properties.

Effects of the CB1 Receptor Antagonists AM6545 and AM4113 on Insulin Resistance in a High-Fructose High-Salt Rat Model of Metabolic Syndrome

“…In the present study, high-fructose/high-salt intake caused a state of metabolic syndrome as evidenced by hyperinsulinemia, weight gain, dyslipidemia and hyperuricemia as was previously reported [22]. There was also a strong correlation between IR and body weight gain, while both AM6545 and AM4113 decreased body weight in IR animals but with lost IR/body weight correlation.…”

Protective Effect of Coriander (Coriandrum sativum L.) on High-Fructose and High-Salt Diet-Induced Hypertension: Relevant to Improvement of Renal and Intestinal Function

“…Therefore, it is necessary to take renal function parameters into account to analyze this disease. The serum levels of UA and BUN reflect the filtration rate of the glomerular . In our study, rats’ renal function is impaired after consuming a high fructose and salt diet for 8 weeks, which is evidenced by abnormal renal index, UA, BUN, CREA levels, and renal pathological changes in HFSD-fed rats.…”

“…The serum levels of UA and BUN reflect the filtration rate of the glomerular. 37 In our study, rats' renal function is impaired after consuming a high fructose and salt diet for 8 weeks, which is evidenced by abnormal renal index, UA, BUN, CREA levels, and renal pathological changes in HFSD-fed rats. However, the renal index, BUN level, and pathological changes are normalized after being supplemented with coriander, elucidating coriander is able to alleviate HFSD-caused renal impairment.…”

Advances in the Study of Marine Products with Lipid-Lowering Properties

“…Both of them reduced the adipose tissue weight in rats [76]. Some authors [77] have demonstrated that the visceral proteolysis of starfish reduces TC and TG levels and improves lipid metabolism in HFD rats. Another research show that hydrolysates of Octopus vulgaris muscles proteins decreases the levels of TG, TC and LDL-C in hyperglycemia rats induced by alloxan, improves the lipid metabolism as well as reverses the increase in the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and gamma-glutamyl transpeptidase caused by alloxan, playing a certain role in liver protection [78].…”