Assessment of Circulating lncRNA H19 in Ankylosing Spondylitis Patients and Its Correlation with Disease Activity

Esawy, Marwa M.; Ebaid, Amany; Abd-elhameed, Amir; Thagfan, Felwa A.; Mubaraki, Murad A.; Alazzouni, Ahmed S.; Dkhil, Mohamed A.; Shabana, Marwa A.

doi:10.3390/jpm13060914

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…In a study conducted by Zhang et al, it was observed that the lncRNA H19 exhibited a significant upregulation in AS patients compared to healthy controls ( Zhang et al, 2020 ). This finding was further corroborated by another study conducted by Marwa M. Esawy et al ( Esawy et al, 2023 ). In the experiment conducted by Zhang et al, the knockdown of H19 downregulated vitamin D receptor (VDR) and miR-675-5p expressions while promoting miR-22-5p expression in peripheral blood mononuclear cells (PBMCs).…”

Section: Lncrnas Involved In the Pathogenesis Of Assupporting

confidence: 82%

A review of long non-coding RNAs in ankylosing spondylitis: pathogenesis, clinical assessment, and therapeutic targets

Wang,

Yang,

et al. 2024

Front. Cell Dev. Biol.

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Ankylosing spondylitis (AS) is a chronic immune-mediated type of inflammatory arthritis characterized by inflammation, bone erosion, and stiffness of the spine and sacroiliac joints. Despite great efforts put into the investigation of the disease, the pathogenesis of AS remains unclear, posing challenges in identifying ideal targets for diagnosis and treatment. To enhance our understanding of AS, an increasing number of studies have been conducted. Some of these studies reveal that long non-coding RNAs (lncRNAs) play crucial roles in the etiology of AS. Some certain lncRNAs influence the development of AS by regulating inflammatory responses, autophagy, apoptosis, and adipogenesis, as well as the proliferation and differentiation of cells. Additionally, some lncRNAs demonstrate potential as biomarkers, aiding in monitoring disease progression and predicting prognosis. In this review, we summarize recent studies concerning lncRNAs in AS to elucidate the underlying mechanisms in which lncRNAs are involved and their potential values as biomarkers for disease assessment and druggable targets for therapy.

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Section: Lncrnas Involved In the Pathogenesis Of Assupporting

confidence: 82%

A review of long non-coding RNAs in ankylosing spondylitis: pathogenesis, clinical assessment, and therapeutic targets

Wang,

Yang,

et al. 2024

Front. Cell Dev. Biol.

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Relationships between emotional state, sleep disturbance and health-related quality of life in patients with axial spondyloarthritis

Cai,

Chen,

Dou

et al. 2024

Clin Rheumatol

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Long non-coding RNA (H19) in patients with spondyloarthritis: association with disease parameters and ultrasonographic findings

EL-Zwawy,

Soliman,

Elsayed

et al. 2024

Egypt Rheumatol Rehabil

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Background Spondyloarthritis is a well-known chronic inflammatory disorder; despite recent advances, its genetic basis remains poorly understood. Recently, long non-coding RNA (H19) was identified to be associated with various human cancers and studied in some autoimmune diseases. Musculoskeletal ultrasound has been shown to have good sensitivity and specificity in detecting enthesitis. The Belgrade Ultrasound Enthesitis Score (BUSES) has recently been proposed as a comprehensive ultrasound enthesitis scoring system for differentiating between individuals with enthesitis associated with spondyloarthritis and those without spondyloarthritis. Aim The current work aimed to study the role of long non-coding RNA (H19) as a potential biomarker in axial spondyloarthritis and its relationship with the different disease parameters (clinical and laboratory), disease activity, and functional status as well as the relation between long non-coding RNA (H19) and articular manifestations using ultrasonographic assessment of enthesitis. Results Long non-coding RNA (H19) expression was statistically higher in axial spondyloarthritis patients than controls; there are no statistically significant correlations between long non-coding RNA (H19) relative expression and any of the listed parameters (ESR, CRP, ASDAS-CRP, BASDAI, BASFI, BASMI, BUSES, SPARCC index, mSASSS). As regards the Spearman correlation of Belgrade Ultrasound Enthesitis Score, it showed a statistically significant positive correlation with ASDAS-CRP, BASDAI, and BASMI (p value: 0.002, 0.02, and 0.046, respectively). Conclusion Both long non-coding RNA (H19) and Belgrade Ultrasound Enthesitis Score have good discriminative ability between patients with axial spondyloarthritis and normal population; this suggests a possible role in early diagnosis for patients with axial spondyloarthritis who do not fulfill ASAS classification criteria. Their role to monitor the disease activity still needs further studies to be established. Musculoskeletal ultrasound is much more accurate in the assessment of enthesis than clinical examination. Further studies are needed to study the correlation between ultrasonographic entheseal scores and activity markers either clinically or laboratory.

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Assessment of Circulating lncRNA H19 in Ankylosing Spondylitis Patients and Its Correlation with Disease Activity

Cited by 3 publications

References 46 publications

A review of long non-coding RNAs in ankylosing spondylitis: pathogenesis, clinical assessment, and therapeutic targets

A review of long non-coding RNAs in ankylosing spondylitis: pathogenesis, clinical assessment, and therapeutic targets

Relationships between emotional state, sleep disturbance and health-related quality of life in patients with axial spondyloarthritis

Long non-coding RNA (H19) in patients with spondyloarthritis: association with disease parameters and ultrasonographic findings

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