Assessment of Citrate Concentrations in Citrus Fruit-Based Juices and Beverages: Implications for Management of Hypocitraturic Nephrolithiasis

Haleblian, George E.; Leitão, Victor A.; Pierre, Sean A.; Robinson, Marnie R.; Albala, David; Ribeiro, Anthony A.; Preminger, Glenn M.

doi:10.1089/end.2008.0069

Cited by 55 publications

(35 citation statements)

References 23 publications

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“…Information on citrate concentrations in citrus juices, non citrus juices and commercially available citrus based beverages are now available (Haleblian et al 2008) (11).…”

Section: Citrus and Non Citrus Juicesmentioning

confidence: 99%

Dietary treatment of urinary risk factors for renal stone formation. A review of CLU Working Group

Prezioso

Strazzullo

Lotti

et al. 2015

Arch Ital Urol Androl

162

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Objective: Diet interventions may reduce the risk of urinary stone formation and its recurrence, but there is no conclusive consensus in the literature regarding the effectiveness of dietary interventions and recommendations about specific diets for patients with urinary calculi. The aim of this study was to review the studies reporting the effects of different dietary interventions for the modification of urinary risk factors in patients with urinary stone disease. Materials and Methods: A systematic search of the Pubmed database literature up to July 1, 2014 for studies on dietary treatment of urinary risk factors for urinary stone formation was conducted according to a methodology developed a priori. Studies were screened by titles and abstracts for eligibility. Data were extracted using a standardized form and the quality of evidence was assessed. Results: Evidence from the selected studies were used to form evidencebased guideline statements. In the absence of sufficient evidence, additional statements were developed as expert opinions. Conclusions: General measures: Each patient with nephrolithiasis should undertake appropriate evaluation according to the knowledge of the calculus composition. Regardless of the underlying cause of the stone disease, a mainstay of conservative management is the forced increase in fluid intake to achieve a daily urine output of 2 liters. Hypercalciuria: Dietary calcium restriction is not recommended for stone formers with nephrolithiasis. Diets with a calcium content ≥ 1 g/day (and low protein-low sodium) could be protective against the risk of stone formation in hypercalciuric stone forming adults. Moderate dietary salt restriction is useful in limiting urinary calcium excretion and thus may be helpful for primary and secondary prevention of nephrolithiasis. A low-normal protein intake decrease calciuria and could be useful in stone prevention and preservation of bone mass. Omega-3 fatty acids and bran of different origin decreases calciuria, but their impact on the urinary stone risk profile is uncertain. Sports beverage do not affect the urinary stone risk profile. Hyperoxaluria: A diet low in oxalate and/or a calcium intake normal to high (800-1200 mg/day for adults) reduce the urinary excretion of oxalate, conversely a diet rich in oxalates and/or a diet low in calcium increase urinary oxalate. A restriction in protein intake may reduce the urinary excretion of oxalate although a vegetarian diet may lead to an increase in urinary oxalate. Adding bran to a diet low in oxalate cancels its effect of reducing urinary oxalate. Conversely, the addition of supplements of fruit and vegetables to a mixed diet does not involve an increased excretion of oxalate in the urine. The intake of pyridoxine reduces the excretion of oxalate. Hyperuricosuria: In patients with renal calcium stones SummaryNo conflict of interest declared. DOI: 10.4081/aiua.2015.2.105the decrease of the urinary excretion of uric acid after restriction of dietary protein and purine is suggested although not cle...

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“…Information on citrate concentrations in citrus juices, non citrus juices and commercially available citrus based beverages are now available (Haleblian et al 2008) (11).…”

Section: Citrus and Non Citrus Juicesmentioning

confidence: 99%

Dietary treatment of urinary risk factors for renal stone formation. A review of CLU Working Group

Prezioso

Strazzullo

Lotti

et al. 2015

Arch Ital Urol Androl

162

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“…Acid stimuli are commonly found in overripe or rotting fruits that are common food sources: in fact they have been detected in the juice of different Citrus species such as grapefruit (64.7 mM/L), lemon (47.66 mM/L) and orange (47.36 mM/L) (Haleblian et al 2008).…”

Section: Behaviourmentioning

confidence: 99%

Morphological and electrophysiological analysis of tarsal sensilla in the medfly Ceratitis capitata (Wiedemann, 1824) (Diptera: Tephritidae)

Loy

Solari

Isola

et al. 2016

Italian Journal of Zoology

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The Mediterranean fruit fly, Ceratitis capitata (Wiedemann, 1824) (Diptera: Tephritidae), is a polyphagous pest in horticulture, mainly targeting pomaceous and citrus fruits. To gain better knowledge about its chemosensory system related to taste, essential for behavioural strategies and localisation of host plants, we examined the tarsal external morphology by highresolution scanning electron microscopy, focusing on sensilla. Numerous trichoid and chaetica sensilla, related to taste and mechanoreceptor systems, and other types of sensilla are present in tarsal segments. The responses of specific trichoid chemosensilla were also studied through electrophysiological experiments by stimulation with sodium chloride, fructose and four bitter stimuli. Electrophysiological data allowed us to distinguish three types of different neurons: high ("H"), middle ("M") and small ("S"). Increasing concentrations of sodium chloride enhanced the activity of H cells, while fructose boosted M cells activity. On the contrary, S cells showed no increase in spike activity after stimulation with these substances. Bitter stimuli induced no significant response on these cells. Behavioural assays showed no statistical difference among the responses to sugars, bitter substances and citric acid. Our results on taste stimuli will be useful in increasing knowledge of Ceratitis chemoreception, fundamental in new integrated pest management.

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“…Meanwhile, citric acid is naturally concentrated in citrus fruits with lemon juice and lime juice being rich sources of citric acid and intake of these has been suggested as an effective means of treating oxalate stones. 1,51,52 These studies have addressed the utility of dietary intervention with fruits and fruit juices with high citrate content (orange juice and lemonade) as an alternative to potassium citrate in increasing urinary pH and citrate, but the combination of citrate supplementation and fruit juices was not evaluated. This latter approach might prove a useful one combining the advantages of both classes of food additives.…”

Section: 26mentioning

confidence: 99%

Citric Acid Effects on Brain and Liver Oxidative Stress in Lipopolysaccharide-Treated Mice

Abdel-Salam

Youness²,

Mohammed³

et al. 2014

Journal of Medicinal Food

129

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Citric acid is a weak organic acid found in the greatest amounts in citrus fruits. This study examined the effect of citric acid on endotoxin-induced oxidative stress of the brain and liver. Mice were challenged with a single intraperitoneal dose of lipopolysaccharide (LPS; 200 lg/kg). Citric acid was given orally at 1, 2, or 4 g/kg at time of endotoxin injection and mice were euthanized 4 h later. LPS induced oxidative stress in the brain and liver tissue, resulting in marked increase in lipid peroxidation (malondialdehyde [MDA]) and nitrite, while significantly decreasing reduced glutathione, glutathione peroxidase (GPx), and paraoxonase 1 (PON1) activity. Tumor necrosis factor-alpha (TNF-a) showed a pronounced increase in brain tissue after endotoxin injection. The administration of citric acid (1-2 g/kg) attenuated LPS-induced elevations in brain MDA, nitrite, TNF-a, GPx, and PON1 activity. In the liver, nitrite was decreased by 1 g/kg citric acid. GPx activity was increased, while PON1 activity was decreased by citric acid. The LPS-induced liver injury, DNA fragmentation, serum transaminase elevations, caspase-3, and inducible nitric oxide synthase expression were attenuated by 1-2 g/kg citric acid. DNA fragmentation, however, increased after 4 g/kg citric acid. Thus in this model of systemic inflammation, citric acid (1-2 g/kg) decreased brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation.

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Assessment of Citrate Concentrations in Citrus Fruit-Based Juices and Beverages: Implications for Management of Hypocitraturic Nephrolithiasis

Cited by 55 publications

References 23 publications

Dietary treatment of urinary risk factors for renal stone formation. A review of CLU Working Group

Dietary treatment of urinary risk factors for renal stone formation. A review of CLU Working Group

Morphological and electrophysiological analysis of tarsal sensilla in the medfly Ceratitis capitata (Wiedemann, 1824) (Diptera: Tephritidae)

Citric Acid Effects on Brain and Liver Oxidative Stress in Lipopolysaccharide-Treated Mice

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