Assessment of clinical application of test-dose concept for theophylline in patients with respiratory failure.

Goto, Mitsuyoshi; Yoshida, Hiroshi; Terashima, Toshio; Kusafuka, Hiromitsu; Horiuchi, Tadashi; Mizugaki, Ichiro; Johno, Ikuo; Kitazawa, Shigeru

doi:10.1248/bpb1978.12.573

Journal of Pharmacobio-Dynamics

1989

DOI: 10.1248/bpb1978.12.573

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Assessment of clinical application of test-dose concept for theophylline in patients with respiratory failure.

Mitsuyoshi Goto

Hiroshi Yoshida²,

Toshio Terashima³

et al.

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Cited by 2 publications

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References 24 publications

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“…The pharmacokinetic parameters and the metabolism of some drugs (especially those metabolized by the hepatic route) can be modified by a change in blood gas parameters, as has been reported in vivo and in vitro (Cumming & Mannering, 1970;Cumming, 1975; Letarte & du Souich, 1984;Goto et al, 1989).…”

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Monitoring of blood gas parameters and acid-base balance of pregnant and non-pregnant rabbits (Oryctolagus cuniculus) in routine experimental conditions

et al. 1992

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SummaryBlood gas parameters and acid-base balance values were determined in adult pregnant New Zealand rabbits (Oryctolagus cuniculus) in standard laboratory housing conditions and during anaesthesia with an association of ketamine-chlorpromazine, administered before surgical procedures. All the variables were also studied in adult non-pregnant female, used as controls. No differences in pH, S02C, 02Hb, COHb, s02m and a-vD02 were found between pregnant and non-pregnant rabbits in physiologicalconditions and during anaesthesia. Ketamine-chlorpromazine and pregnancy seemed to change the other parameters used to assess the acid-base balance and the oxygenation conditions. Anaesthesia affected only Rb, 02et, 02Cap, CC02 and P50. The additive effect of pregnancy and anaesthesia modified pC02, p02, HC0 3 -, TC02, BEb, SBC, BEecf, A-aD0 2 , RI, MetHb, RHb, Ca02 and CV02' The patterns described are close to those of other species, suggesting the New Zealand rabbit might be a reliable animal model for monitoring selected variables.

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Monitoring of blood gas parameters and acid-base balance of pregnant and non-pregnant rabbits (Oryctolagus cuniculus) in routine experimental conditions

et al. 1992

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Placental transfer of theophylline during in situ perfusion in the rabbit

Omarini

Barzaco

Bortolotti

et al. 1991

Journal of Pharmacological Methods

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Assessment of clinical application of test-dose concept for theophylline in patients with respiratory failure.

Cited by 2 publications

References 24 publications

Monitoring of blood gas parameters and acid-base balance of pregnant and non-pregnant rabbits (Oryctolagus cuniculus) in routine experimental conditions

Monitoring of blood gas parameters and acid-base balance of pregnant and non-pregnant rabbits (Oryctolagus cuniculus) in routine experimental conditions

Placental transfer of theophylline during in situ perfusion in the rabbit

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