Assessment of clinical outcomes and histomorphometric findings in alveolar ridge augmentation procedures with allogeneic bone block grafts: A systematic review and meta-analysis

Pérez-González, Fabian; Molinero‐Mourelle, Pedro; Sánchez-Labrador, Luis; Sáez-Alcaide, L-M; Limones, Álvaro; Brinkmann, Jorge Cortés-Bretón; López-Quiles, Juan

doi:10.4317/medoral.23353

Cited by 15 publications

(18 citation statements)

References 36 publications

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“…It should be noted that the highest values were found with allogeneic bone rings, with a 97.93% survival rate after a 12.70-month follow-up. These findings agree with previous systematic reviews analyzing implant survival rates after GBR and bone block grafting, which report survival rates of between 97% and 100% [ 5 – 7 , 30 ].…”

Section: Discussionsupporting

confidence: 93%

“…The mean survival rate obtained in the present review was 97.26%; with 100% for allogeneic bone rings and 95.04% for autogenous bone rings. These outcomes are similar to other vertical ridge augmentation procedures [ 7 , 30 , 33 ].…”

Section: Discussionsupporting

confidence: 81%

“…Unlike most of the techniques described for vertical ridge augmentation, the main clinical advantage of BRT is the possibility of a simultaneous approach, reconstructing a vertical alveolar ridge defect at the same time as implant placement, which reduces treatment time considerably. In addition, placing allogeneic bone rings can reduce or eliminate several complications related to autogenous bone block harvesting, such as the higher morbidity, the need for a donor site, neurosensorial disturbances, and the limited amount of bone available, among others [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness of the bone ring technique and simultaneous implant placement for vertical ridge augmentation: a systematic review

et al. 2020

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Background Dimensional changes after dental extraction frequently lead to situations in which bone augmentation procedures are required prior to dental implant placement. Bone ring technique (BRT) has been described as a one-stage approach to restore vertical alveolar ridge defects, in which an autogenous or allogeneic cortico-cancellous bone block graft is stabilized with a dental implant inserted simultaneously. The objective of this systematic review was to evaluate the clinical performance of BRT. Materials and methods This review was conducted according to PRISMA guidelines. An electronic search was conducted in four databases: (1) The National Library of Medicine (MEDLINE/PubMed) via Ovid; (2) Web of Science (WOS); (3) SCOPUS; and (4) Cochrane Central Register of Controlled Trials (CENTRAL). The Newcastle-Ottawa Quality Assessment Scale and The Joanna Briggs Institute Critical Appraisal tool were used to assess the quality of evidence in the studies reviewed. Results Sixteen studies with a total of 186 patients treated with 219 bone rings bocks were included in the review. The studies showed a mean bone gain of 4.94 mm, mean bone resorption of 0.83 mm, and mean marginal bone loss of 0.57 mm after a mean follow-up period of 13.35 months. A mean bone ring survival rate of 97.26% and implant survival rate of 94.97% were recorded. Conclusions BRT would appear to be an adequate alternative technique for restoring single vertical alveolar ridge defects with simultaneous dental implant placement. However, further studies comparing this technique with other vertical ridge augmentation procedures in different clinical scenarios are needed to confirm the present results.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

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Effectiveness of the bone ring technique and simultaneous implant placement for vertical ridge augmentation: a systematic review

et al. 2020

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“…The analysis of this work used histomorphometry and immunohistochemistry, these methodologies are widely used to assess cell tissue components involved in the osseointegration and bone remodeling process. [13][14][15][16] The results of the present study showed that the synthetic nano-HA/ß-TCP mixture biomaterial used to fill calvarial bone defects in a rat model induced a better cell response than deproteinized bovine bone mineral (DBBM). Nano-HA/ß-TCP mixture showed larger percentages of stained areas with Masson's trichrome, PAS, MMP-9, and TNF-α than DBBM biomaterial.…”

Section: Discussionmentioning

confidence: 75%

Performance of Nano-Hydroxyapatite/Beta-Tricalcium Phosphate and Xenogenic Hydroxyapatite on Bone Regeneration in Rat Calvarial Defects: Histomorphometric, Immunohistochemical and Ultrastructural Analysis

Brum¹,

Frigo²,

Santos³

et al. 2021

IJN

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Background: Synthetic biomaterials have played an increasingly prominent role in the substitution of naturally derived biomaterials in current surgery practice. In vitro and in vivo characterization studies of new synthetic biomaterials are essential to analyze their physicochemical properties and the underlying mechanisms associated with the modulation of the inflammatory process and bone healing. Purpose: This study compares the in vivo tissue behavior of a synthetic biomaterial nano-hydroxyapatite/beta-tricalcium phosphate (nano-HA/ß-TCP mixture) and deproteinized bovine bone mineral (DBBM) in a rat calvarial defect model. The innovation of this work is in the comparative analysis of the effect of new synthetic and commercially xenogenic biomaterials on the inflammatory response, bone matrix gain, and stimulation of osteoclastogenesis and osteoblastogenesis. Methods: Both biomaterials were inserted in rat defects. The animals were divided into three groups, in which calvarial defects were filled with xenogenic biomaterials (group 1) and synthetic biomaterials (group 2), or left unfilled (group 3, controls). Sixty days after calvarial bone defects filled with biomaterials, periodic acid Schiff (PAS) and Masson's trichrome staining, immunohistochemistry tumor necrosis factoralpha (TNF-α), matrix metalloproteinase-9 (MMP-9), and electron microscopy analyses were conducted. Results: Histomorphometric analysis revealed powerful effects such as a higher amount of proteinaceous matrix and higher levels of TNF-α and MMP-9 in bone defects treated with alloplastic nano-HA/ß-TCP mixture than xenogenicxenogic biomaterial, as well as collagen-proteinaceous material in association with hydroxyapatite crystalloids. Conclusion:These data indicate that the synthetic nano-HA/ß-TCP mixture enhanced bone formation/remodeling in rat calvarial bone defects. The nano-HA/ß-TCP did not present risks of cross-infection/disease transmission. The synthetic nano-hydroxyapatite/beta-tricalcium phosphate mixture presented adequate properties for guided bone regeneration and guided tissue regeneration for dental surgical procedures.

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“…Although autogenous bone has been described by some authors as the ‘ gold standard ’ for bone augmentation procedures due to its osteogenic, osteoinductive, and osteoconductive properties, it suffers several disadvantages, such as higher morbidity, the need for a donor site, and the limited quantity of bone available [ 37 ]. Besides, autogenous bone block grafting presents a range of complications derived from the technique, occurring in 30–50% of cases [ 38 , 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Horizontal Ridge Augmentation: A Comparison between Khoury and Urban Technique

Sánchez-Sánchez

Pickert

Sánchez-Labrador

et al. 2021

Biology

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Purpose. The objective of this systematic review was to evaluate and compare the clinical efficacy of horizontal alveolar ridge augmentation techniques described by Khoury and Urban. Methods. A systematic electronic search in the MEDLINE databases, SCOPUS, WOS, and the Cochrane Central Register of Controlled Trials (CENTRAL) as well as a manual search, were conducted independently by two reviewers up to July 2021. Results. Six studies met the pre-established inclusion criteria and were included in the descriptive analysis. Due to the heterogeneity found across the included studies, meta-analysis could not be performed. Horizontal bone gain was between 3.93 ± 0.9 mm and 5.02 ± 0.8 mm with the Khoury technique and between 3.9 ± 0.9 mm and 5.68 ± 1.42 mm with the Urban technique. Similar complication rates were reported in both groups: infection (7%), in the Khoury technique, and membrane exposure (3.2–13.6%), in the Urban technique, being the most frequent events. Conclusions. Both techniques were found to be effective, in terms of clinical bone gain, for horizontal alveolar ridge gain. Nevertheless, available literature is limited, and there is a lack of comparative studies to better evaluate the results.

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Assessment of clinical outcomes and histomorphometric findings in alveolar ridge augmentation procedures with allogeneic bone block grafts: A systematic review and meta-analysis

Cited by 15 publications

References 36 publications

Effectiveness of the bone ring technique and simultaneous implant placement for vertical ridge augmentation: a systematic review

Effectiveness of the bone ring technique and simultaneous implant placement for vertical ridge augmentation: a systematic review

Performance of Nano-Hydroxyapatite/Beta-Tricalcium Phosphate and Xenogenic Hydroxyapatite on Bone Regeneration in Rat Calvarial Defects: Histomorphometric, Immunohistochemical and Ultrastructural Analysis

Horizontal Ridge Augmentation: A Comparison between Khoury and Urban Technique

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