Assessment of Combined Therapy of Histochrome and Nebivalol as Angioprotectors on the Background of Experimental Hypertension by Magnetic Resonance Angiography

Агафонова, И. Г.; Kotelnikov, V. N.; Гельцер, Б. И.; Kolosova, N. G.; Stonik, Valentin A.

doi:10.1007/s00723-017-0960-3

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…These findings suggest that spinochrome D (21) could be cardioprotective against the cytotoxicity of doxorubicin. 40) It was shown that histochrome (echinochrome, 20) enhances the vasodilatory effect of selective beta1 blocker, nebivalol, in cerebral and renal arteries, using a combined therapy in the renovascular model of arterial hypertension, induced in Wistar and OXYS rat strains. Comparative magnetic resonance imaging (MRI) angiography and MRI morphometry of the cerebral and renal arteries in hypertensive rats showed that histochrome expands the therapeutic potential of nebivalol due to angioprotective effects in the vascular region of the target organs.…”

Section: Cardioprotective and Anti-ischemic Propertiesmentioning

confidence: 99%

1,4-Naphthoquinones: Some Biological Properties and Application

2020

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Over the past decade, a number of new 1,4-naphthoquinones have been isolated from natural sources and new 1,4-naphthoquinones with diverse structural features have been synthesized. Cardioprotective, antiischemic, hepatoprotective, neuroprotective and some other new properties were found for these compounds; their role in protecting against neurodegenerative diseases has been established. Their anti-inflammatory, antimicrobial and antitumor activities have been studied in more detail; new, previously unknown intracellular molecular targets and mechanisms of action have been discovered. Some compounds of this class are already being used as a medicinal drugs and some substances can be used as biochemical tools and probes for non-invasive detection of pathological areas in cells and tissues in myocardial infarction and neurodegenerative diseases using modern molecular imaging techniques.

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Section: Cardioprotective and Anti-ischemic Propertiesmentioning

confidence: 99%