Assessment of compliance and relapse in patients with schizophrenia before and after the onset of COVID-19 pandemic

Bassiony, Medhat M.; Sehlo, Mohammad Gamal; Ibrahim, Eman F.; Zayed, Alaa Elsayed Mohamed; Atwa, Samar A.

doi:10.1080/13651501.2022.2124175

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…The main diagnosis in repeated episode psychosis was that of schizophrenia, compared to acute & transient psychosis in the FEP group. This is consistent with findings from case reports during the pandemic, and supported by a multicentre observational study, of increased rates of brief reactive psychosis (Valdés-Florido et al, 2022), and relapse of existing psychotic illness driven by pandemic related stress as a major contributory factor (Bassiony et al, 2022). Pandemic-related changes in access to and provision of community mental health services as well as treatment and other therapeutic interventions, were also likely contributing factors, in particular repeated episode psychosis Jagadheesan et al, 2021).…”

Section: Discussionsupporting

confidence: 89%

The impact of COVID-19 on acute psychiatric admissions for first and repeated episode psychosis

Kelbrick,

da Silva,

Griffiths

et al. 2023

Int J Soc Psychiatry

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Background: There is limited evidence of the longer-term impact of the COVID-19 pandemic on acute admissions for psychosis in the UK. Aims: We examined the impact of COVID-19 on rates of admissions for first and repeated episode psychosis, and changes in patient profile and seasonal patterns, over a period of 12 months. Method: We conducted a retrospective case note review of all patients admitted with a primary psychosis (F20-29 ICD 10 diagnosis) to an NHS psychiatric inpatient unit. We compared the 12 months pre-COVID-19 period between 1 March 2019 and 28 February 2020, and the 12 months post-COVID-19 period between 1 March 2020 and 28 February 2021. Results: The results showed increase rates of admissions post-COVID-19 in both first and repeated episode psychosis, the patient profile had more females and older age in the repeated episode group, with increased employment rates. Combined group data for both pre- and post-COVID-19 periods showed an increased trend in spring and summer admissions, and even though not statistically significant, more pronounced post-COVID-19. Conclusions: Our findings highlight the effect of the COVID-19 pandemic on acute psychosis admissions over a 12-month period. The results provide evidence for the ‘stress-pathogenesis’ in the context of genetic vulnerability in psychosis. Preventative strategies in the context of the ‘stress-pathogenesis model’, improved access to and responsiveness within NHS transformation efforts needs to be adjusted to fit local need and environmental changes.

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Section: Discussionsupporting

confidence: 89%

The impact of COVID-19 on acute psychiatric admissions for first and repeated episode psychosis

Kelbrick,

da Silva,

Griffiths

et al. 2023

Int J Soc Psychiatry

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“…En el caso de trastornos psicóticos, el aumento en la frecuencia de casos puede deberse al aumento de situaciones estresantes en la pandemia -problemas financieros, duelos, entre otros-, lo que genera a su vez, recaídas o empeoramiento del curso de la enfermedad (16) . Así mismo, el confinamiento provocó una disminución en las consultas médicas externas (17) , que pudo derivar en la descontinuación o el abandono de la terapia establecida, y por ende, en un incremento en las recaídas y descompensación de cuadros que, en situaciones normales de atención de salud eran estables (18) . Por otro lado, se ha visto que durante la pandemia hubo un aumento del estrés, ansiedad y un aumento de pensamientos suicidas, lo cual pudo generar el aumento en la frecuencia de ingresos en trastornos afectivos, como el trastorno bipolar (19) .…”

Section: Discussionunclassified

“…En nuestra muestra los pacientes estaban en edad productiva laboral, sin embargo, el 56% eran desempleados y la mayoría de pacientes pertenecían a un nivel socioeconómico bajo, lo cual también se considera un factor estresante para pacientes psicóticos (16) . Más del 70,0% de pacientes eran solteros y la mayoría vivía con familia extendida (tíos, abuelos, padres adultos mayores), lo cual puede estar relacionado con un apoyo familiar defi-ciente, que conlleva dificultades en la adherencia al tratamiento y el seguimiento, generando un aumento de las recaídas (18) . El 60,0% de los pacientes eran continuadores, por lo que probablemente volvieron al hospital por un episodio de recaída, lo cual se suele asociar al abandono de la medicación o la falta de monitorización por parte de su médico tratante.…”

Section: Discussionunclassified

Frecuencia de trastornos mentales y sus características sociodemográficas en pacientes con COVID-19 ingresados en un hospital psiquiátrico de Lima Metropolitana

Villanueva,

Young

2023

An Fac med

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Introduction. The description of the characteristics and diagnoses of psychiatric patients with COVID-19 during the pandemic has been poorly described in Peru. Objective. To describe the frequency of mental disorders and the associated sociodemographic characteristics of patients with a positive antigen test for COVID-19 in a peruvian psychiatric hospital from July 2020 to July 2021. Methods. For this descriptive study we analyzed 100 medical records of patients between 18 and 70 years old. The variables studied were the diagnosis according to ICD-10 and sociodemographic features such as age, gender, educational status, employment, days of admission. Results. The most common diagnoses were “Schizophrenia, schizotypal disorders and delusional disorders” (49%) and “mood disorders” (37%), 66% belonged to the lowest socioeconomic levels and 60% were recurrent patients. The month of April 2021 presented the highest number of admissions (n=15). Conclusion. In a year of observation during the COVID-19 outbreak, 100 patients with psychiatric diagnosis who also had SARS-CoV-2 infection were admitted to a reference psychiatric hospital, most of these patients had psychotic disorders.

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“…Subsequently, wider use of telehealth and digital tools was promoted, such as smartphone apps, in providing medical services for the reduction of person-to-person contact to lower the likelihood of COVID-19 transmission to patients [ 14 ]. Poor medication adherence was one of the major causes of the increasing relapse rate among patients with schizophrenia during the COVID-19 pandemic [ 15 ], and it is crucial to use remote monitoring to track oral medication adherence to lower relapse rates or the deterioration of psychiatric symptoms.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a Smartphone App in Enhancing Medication Adherence and Accuracy in Individuals With Schizophrenia During the COVID-19 Pandemic: Randomized Controlled Trial

Chen,

Hsu,

Lin

et al. 2023

JMIR Ment Health

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Background Poor medication adherence or inaccuracy in taking prescribed medications plays an important role in the recurrence or worsening of psychiatric symptoms in patients with schizophrenia, and the COVID-19 pandemic impacted their medication adherence with exacerbated symptoms or relapse. The use of mobile health services increased during the COVID-19 pandemic, and their role in improving mental health is becoming clearer. Objective This study aimed to explore the effectiveness of a smartphone app (MedAdhere) on medication adherence and accuracy among patients with schizophrenia and to measure their psychiatric symptoms and cognitive functions. Methods In this 12-week experimental study, participants were provided interventions with the MedAdhere app, and data were collected between June 2021 and September 2022. A total of 105 participants were randomly assigned to either the experimental or control groups. We used the Positive and Negative Syndrome Scale and Mini-Mental State Examination to measure the participants’ psychiatric symptoms and cognitive functions. Generalized estimating equations were used for data analysis. Results A total of 94 participants met the inclusion criteria and completed the protocol, and the medication adherence rate of the experimental group was 94.72% (2785/2940) during the intervention. Psychotic symptoms (positive, negative, and general psychopathology symptoms) and cognitive functions (memory, language, and executive function) were significantly improved in the experimental group compared to the control group after the intervention. Conclusions The MedAdhere app effectively and significantly improved medication adherence and, thereby, the psychiatric symptoms of patients with schizophrenia. This artificial intelligence assisted app could be extended to all patients who need to be reminded to take medication on schedule. Trial Registration ClinicalTrials.gov NCT05892120; https://clinicaltrials.gov/study/NCT05892120

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Assessment of compliance and relapse in patients with schizophrenia before and after the onset of COVID-19 pandemic

Cited by 6 publications

References 29 publications

The impact of COVID-19 on acute psychiatric admissions for first and repeated episode psychosis

The impact of COVID-19 on acute psychiatric admissions for first and repeated episode psychosis

Frecuencia de trastornos mentales y sus características sociodemográficas en pacientes con COVID-19 ingresados en un hospital psiquiátrico de Lima Metropolitana

Efficacy of a Smartphone App in Enhancing Medication Adherence and Accuracy in Individuals With Schizophrenia During the COVID-19 Pandemic: Randomized Controlled Trial

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