Assessment of compliance with antipsychotic treatmentand resource utilization in a medicaid population

Eaddy, Michael; Grogg, Amy; Locklear, Julie

doi:10.1016/j.clinthera.2005.02.003

Cited by 95 publications

(76 citation statements)

References 17 publications

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“…Studies consistently showed that nonadherence was significantly associated with poorer outcomes, including greater risk of hospitalization [Ahn et al 2008;Eaddy et al 2005;Gilmer et al 2004;Law et al 2008;Morken et al 2008;Svarstad et al 2001;Valenstein et al 2002;Weiden et al 2004a], greater use of emergency services , longer length of hospital stay Valenstein et al 2002] and greater risk of suicide [Leucht and Heres, 2006;Llorca, 2008]. The consequences to society included having to deal with the consequences of violence , substance abuse and criminal behaviour .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it was difficult to make comparisons, and it was not feasible to pool the quantitative results on the relationship between nonadherence and increased risk of hospitalization. However, regardless of the heterogeneity in adherence measures used, all studies consistently showed a link between lower adherence rates and higher hospitalization risk [Ahn et al 2008;Eaddy et al 2005;Gilmer et al 2004;Karve et al 2009;Knapp et al 2004;Laan et al 2010;Law et al 2008;Morken et al 2008;Svarstad et al 2001].…”

Section: Consequences To Patientsmentioning

confidence: 99%

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Medication adherence in schizophrenia: factors influencing adherence and consequences of nonadherence, a systematic literature review

Higashi¹,

Medic

Littlewood

et al. 2013

Therapeutic Advances in Psychopharmacology

479

381

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Background: Nonadherence to medication is a recognized problem and may be the most challenging aspect of treatment. Methods:We performed a systematic review of factors that influence adherence and the consequences of nonadherence to the patient, healthcare system and society, in patients with schizophrenia. Particular attention was given to the effect of nonadherence on hospitalization rates, as a key driver of increased costs of care. A qualitative systematic literature review was conducted using a broad search strategy using disease and adherence terms. Due to the large number of abstracts identified, article selection was based on studies with larger sample sizes published after 2001. Thirty-seven full papers were included: 15 studies on drivers and 22 on consequences, of which 12 assessed the link between nonadherence and hospitalization. Results: Key drivers of nonadherence included lack of insight, medication beliefs and substance abuse. Key consequences of nonadherence included greater risk of relapse, hospitalization and suicide. Factors positively related to adherence were a good therapeutic relationship with physician and perception of benefits of medication. The most frequently reported driver and consequence were lack of insight and greater risk of hospitalization respectively. Conclusions: Improving adherence in schizophrenia may have a considerable positive impact on patients and society. This can be achieved by focusing on the identified multitude of factors driving nonadherence.

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Section: Discussionmentioning

confidence: 99%

Section: Consequences To Patientsmentioning

confidence: 99%

Medication adherence in schizophrenia: factors influencing adherence and consequences of nonadherence, a systematic literature review

Higashi¹,

Medic

Littlewood

et al. 2013

Therapeutic Advances in Psychopharmacology

479

381

View full text Add to dashboard Cite

show abstract

“…The CATIE study, for instance, failed to find any significant differences between medication classes in time to discontinuation (Lieberman et al, 2005). Nonadherence is a major problem with both classes of antipsychotics (Eaddy, Grogg, & Locklear, 2005;Thieda, Beard, Richter, & Kane, 2003;Weiden, Kozma, Grogg, & Locklear, 2004). Adherence is defined as the extent to which a person's behavior coincides with medical or health advice (Haynes, 1979, p. 2).…”

Section: Introductionmentioning

confidence: 99%

The Relationship of Antipsychotic Medication Class and Adherence with Treatment Outcomes and Costs for Florida Medicaid Beneficiaries with Schizophrenia

Becker

Young

Ochshorn

et al. 2007

Adm Policy Ment Health

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While some studies show a significant advantage in adherence rates with use of atypical versus typical antipsychotic medication, others show no advantage or mixed results (Jones et al. (2006). Archives of General Psychiatry, 63, 1079-1087; Rosenheck, (2006). Archives of General Psychiatry, 63, 1074-1076). This study examined treatment outcomes and costs associated with adherence rates by antipsychotic medication class for adult Medicaid beneficiaries in Florida diagnosed with schizophrenia. Outcomes examined include arrests, involuntary commitments, and physical and behavioral healthcare costs. Study findings demonstrate that medication adherence for persons with schizophrenia may be as important to treatment costs and benefits as the class of medication used.

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“…16 Esto último tiene consecuencias tanto para el paciente como para la sociedad. [17][18][19][20] Estudios previos han encontrado que pacientes varones, jóvenes, con bajo nivel socioeconómico, pertenecientes a una minoría, con pobre funcionamiento social y con dificultades en el establecimiento de una adecuada alianza terapéutica presentan mayores dificultades para lograr adherencia en el tratamiento. 8,21 Se ha observado de igual forma que el contexto cultural y la etnicidad también tienen una influencia importante.…”

Section: Introductionunclassified

Adherencia a la medicación antipsicótica en pacientes indígenas con esquizofrenia

Caqueo-Urízar

Urzúa-M

Miranda‐Castillo

et al. 2016

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Assessment of compliance with antipsychotic treatmentand resource utilization in a medicaid population

Cited by 95 publications

References 17 publications

Medication adherence in schizophrenia: factors influencing adherence and consequences of nonadherence, a systematic literature review

Medication adherence in schizophrenia: factors influencing adherence and consequences of nonadherence, a systematic literature review

The Relationship of Antipsychotic Medication Class and Adherence with Treatment Outcomes and Costs for Florida Medicaid Beneficiaries with Schizophrenia

Adherencia a la medicación antipsicótica en pacientes indígenas con esquizofrenia

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